A Comparison Study of the Bioavailability of a Capsule Formulation of LGD-6972 to an Oral Solution Formulation

NCT ID: NCT02672839

Last Updated: 2016-05-18

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE1
• Total Enrollment: 12 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2016-02-29
• Study Completion Date: 2016-05-31

Brief Summary

The purpose of this study is to compare relative oral bioavailability of a capsule formulation of LGD-6972 to a solution formulation of LGD-6972.

Detailed Description

This is a single center, randomized, open-label, single dose study conducted in a 2-way crossover design.

A total of 8 subjects will be enrolled in the study. The duration of participation for each subject will be approximately 36 days, not including a Screening Period of up to 30 days.

Each treatment period, subjects will be admitted to the study site on Day -1 and observed through the morning of Day 3 (48-hour post-dose assessment). Over 2 treatment periods, subjects will receive each of the following treatments as a single dose orally, under fasting conditions, per the randomization (4 subjects per treatment in each treatment period:

Treatment A - 15 mg of LGD-6972 as capsules

Treatment B - 15 mg LGD-6972 as solution

Serial blood samples will be collected through 48 hours following each dose to determine the concentration of LGD 6972 in plasma. Safety assessments will also occur during this time. Subjects will be discharged from the study site after the 48 hour assessments and return to the study site on Days 4, 7, and 14 for follow up procedures. Subjects will return to the study site for the second treatment period after an additional 7 days. Subjects will be discharged from the study after returning to the study site on Day 14 of the second treatment period.

Conditions

Type 2 Diabetes Mellitus (T2DM)

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Period 1 Treatment A

Healthy subjects will receive a single dose orally of LGD-6972 capsules fasted

Group Type: EXPERIMENTAL

LGD-6972 Capsules

Intervention Type: DRUG

15 mg LGD-6972

Period 1 Treatment B

Healthy subjects will receive a single dose orally of LGD-6972 solution fasted

Group Type: EXPERIMENTAL

LGD-6972 Solution

Intervention Type: DRUG

15 mg of LGD-6972

Period 2 Treatment A

Healthy subjects will receive a single dose orally of LGD-6972 capsules fasted

Group Type: EXPERIMENTAL

LGD-6972 Capsules

Intervention Type: DRUG

15 mg LGD-6972

Period 2 Treatment B

Healthy subjects will receive a single dose orally of LGD-6972 solution fasted

Group Type: EXPERIMENTAL

LGD-6972 Solution

Intervention Type: DRUG

15 mg of LGD-6972

Interventions

LGD-6972 Solution

15 mg of LGD-6972

Intervention Type: DRUG

LGD-6972 Capsules

15 mg LGD-6972

Intervention Type: DRUG

Other Intervention Names

LGD-6972 Sodium Salt in Captisol ® (betadex [β-cyclodextrin] sulfobutylether sodium, NF); LGD-6972 Sodium Salt Capsules

Eligibility Criteria

Inclusion Criteria

1. Healthy, adult man or woman, 21 to 65 years of age. If the subject is a woman, she must be surgically sterile (hysterectomy or bilateral oophorectomy or bilateral tubal ligation), or naturally post menopausal for at least 12 months and with a follicle stimulating hormone (FSH) level in the post-menopausal range (if not taking hormone replacement therapy) to be considered for enrollment

2. Willing and able to provide written informed consent

3. Not diabetic and has a fasting blood glucose between 70 and 105 mg/dL, inclusive

4. In good health with no significant concomitant pathology based on medical history, physical examination, ECG, routine laboratory tests (chemistry, hematology, lipid profile, and urinalysis), and vital signs

5. Has a body mass index (BMI) between 18.5 kg/m2 and 30 kg/m2, inclusive, and must weigh more than 45 kg

6. Male subjects must either have a vasectomy or agree that they and any female partners will use 2 acceptable forms of contraception, one of which must be a condom, until 30 days after the last dose of study drug. Other acceptable forms of contraception include hormonal contraceptives, intrauterine device, Depo Provera®, Norplant® System Implants, bilateral tubal ligation, bilateral oophorectomy, hysterectomy, and contraceptive sponge, foam, or jelly.

Exclusion Criteria

1. History of drug and/or alcohol abuse within 2 years prior to screening

2. Unwilling to comply with tobacco, nicotine, alcohol, and caffeine restrictions outlined in the protocol

3. Unwilling to comply with restrictions on strenuous exercise as specified in the protocol

4. Has a history of clinically significant cardiovascular, pulmonary, renal, endocrine, hepatic, neurologic, psychiatric, immunologic, hematologic, gastrointestinal (including pancreatitis), or metabolic disease requiring medical treatment or has any medical problems that pose an increased risk during the study or that may compromise the integrity of the study data

5. Has liver transaminase levels (aspartate aminotransferase [AST] or alanine aminotransferase [ALT]) 10% of the upper limit of normal (ULN), or has creatine kinase (CK) levels 2 × ULN at screening or admission to site (Day 1). Abnormal values at screening may be retested once

6. Has a serum triglyceride level 400 mg/dL at screening. If the triglyceride level is between 400 mg/dL and 500 mg/dL, one retest is permitted

7. Recent history of uncontrolled high blood pressure or has systolic blood pressure 90 mmHg or 140 mmHg or diastolic blood pressure 50 mmHg or 90 mmHg at screening. One or more retests of blood pressure within a reasonable period of time are permissible at the discretion of the Investigator

8. Is taking prescription or non-prescription drugs other than those outlined in the protocol

9. Has a positive screening for hepatitis B virus (HBV), hepatitis C virus (HCV), and/or human immunodeficiency virus (HIV)

10. Woman of childbearing potential

11. Lactating or has a positive pregnancy test

12. Has donated 450 mL of blood within 56 days of admission to the investigational site or has donated blood products within 30 days of admission.

• Minimum Eligible Age: 21 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Medpace, Inc.

INDUSTRY

Sponsor Role: collaborator

Ligand Pharmaceuticals

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Lukasz Biernat, M.D.

Role: PRINCIPAL_INVESTIGATOR

Medpace Clinical Pharmacology

Locations

Medpace, Inc

Cincinnati, Ohio, United States

Countries

United States

Other Identifiers

L6972-03

Identifier Type: -

Identifier Source: org_study_id