The Change of NK Cell Activity After Head and Neck Cancer Surgery

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

29 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-03-24

Study Completion Date

2017-05-04

Brief Summary

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Cellular immunity can be changed after surgery and anesthesia. Tissue injury by surgical procedures significantly reduces the immune function in proportion to the degree of tissue injury. In addition, the use of opioids as analgesics during the perioperative period depress cellular immunity, in particular the activity of the natural killer (NK) cells. This perioperative immunosuppression may cause deleterious consequences on postoperative outcome in cancer patients. The aim of this study is to confirm the presence or extent of the change of NK cell activity between before and after head and neck surgery. Additionally, investigators will identify the clinical or genetic factors related to the change of NK cell activity.

Detailed Description

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Conditions

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The Patients Undergoing Head and Neck Surgery Including Tumor Removal and Reconstruction With Flap

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

1\) The patients undergoing head and neck surgery including tumor removal and reconstruction with flap

Exclusion Criteria

1. patients refusal
2. patients not able to read, or understand the consent form
3. History of Active viral or bacterial infection
4. History of use of immunosuppressive drugs within the last six months
5. History of chemotherapy
6. History of autoimmune disorders
7. Known HIV, Hepatitis B, or Hepatitis C infection
8. Female who is pregnant, nursing
9. ethnicity, other than asian

Minimum Eligible Age

19 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Responsibility Role SPONSOR

Locations

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Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institue, Yonsei Universiy College of Medicine

Seoul, , South Korea

Site Status

Countries

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South Korea

References

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Lee SB, Cha J, Kim IK, Yoon JC, Lee HJ, Park SW, Cho S, Youn DY, Lee H, Lee CH, Lee JM, Lee KY, Kim J. A high-throughput assay of NK cell activity in whole blood and its clinical application. Biochem Biophys Res Commun. 2014 Mar 14;445(3):584-90. doi: 10.1016/j.bbrc.2014.02.040. Epub 2014 Feb 18.

Reference Type BACKGROUND

PMID: 24561245 (View on PubMed)

Other Identifiers

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4-2015-0987

Identifier Type: -

Identifier Source: org_study_id