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Mortality in Cancer Patients Admitted to the Intensive Care Unit in a Resource-limited Setting

NCT ID: NCT02659839

Last Updated: 2016-10-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

142 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-07-31

Study Completion Date

2016-10-31

Brief Summary

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The purpose of this study is to determine 30 day mortality in cancer patients admitted to the intensive care unit in a resource limited setting.

Detailed Description

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The management of cancer patients in the intensive care unit (ICU) has changed dramatically during the last two decades. Initial experiences showed high rates of hospital mortality, reaching up to 75-85% in patients requiring life-sustaining treatments, particularly mechanical ventilation. An increasing number of clinical experiences has been reported pointing to a significant improvement in survival of these patients. However, it is not clear if this results are generalizable to settings with resource constraints. Therefore, the purpose of this study is to determine 30 day mortality in cancer patients admitted to the intensive care unit in a resource limited setting.

This study is a prospective cohort of cancer patients admitted to the ICU in which the investigators will evaluate the prognostic of cancer patients admitted for a ICU trial or treatment in ICU without limitations. This study will not consider any change in the treatment plan of the patients. The source of the data will be the clinical records of the patients during the admission and the records of the cancer unit. There will be no direct contact of the research team with the patients or their family.

Conditions

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Cancer

Keywords

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Cancer Intensive care unit Mortality

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Cancer patients admitted to the ICU

Patients with cancer admitted to the ICU. No intervention will be administered.

Cancer patients admitted to the ICU

Intervention Type OTHER

There will be no change in the standard ICU treatment.

Interventions

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Cancer patients admitted to the ICU

There will be no change in the standard ICU treatment.

Intervention Type OTHER

Other Intervention Names

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Standard intensive care unit management.

Eligibility Criteria

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Inclusion Criteria

* 18 years-old or older
* Histological diagnosis or high clinical suspicious of cancer (solid /hematological), with the exception of non-melanoma skin cancer.
* Functional classification state between 0-3, according to Eastern Cooperative Oncology Group.
* Admission to intensive care unit, because of one or more of the following criteria:

1. Invasive or non-invasive ventilatory support due to acute respiratory failure.
2. Use of vasopressor drugs due to hypotension defined as noradrenaline requirement higher than 0.1 microgram/Kg/min.
3. Renal replacement therapy due to acute renal failure.

Exclusion Criteria

* Absence of cancer recurrences in more than 5 years after diagnosis
* Functional classification state of 4, according to Eastern Cooperative Oncology Group.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Pontificia Universidad Catolica de Chile

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Sebastián Mondaca, MD

Role: PRINCIPAL_INVESTIGATOR

Pontificia Universidad Catolica de Chile

Locations

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Hospital Dr. Sótero del Rio

Santiago, Santiago Metropolitan, Chile

Site Status

Countries

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Chile

References

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Panay S, Ruiz C, Abarca M, Nervi B, Salazar I, Caro P, Muniz S, Briones J, Bruhn A, Mondaca S. Mortality of Adult Patients With Cancer Admitted to an Intensive Care Unit in Chile: A Prospective Cohort Study. J Glob Oncol. 2018 Dec;4:1-9. doi: 10.1200/JGO.18.00091.

Reference Type DERIVED
PMID: 30582431 (View on PubMed)

Other Identifiers

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101015

Identifier Type: -

Identifier Source: org_study_id