Topical Liposomal Amphotericin B Gel Treatment for Cutaneous Leishmaniasis

NCT ID: NCT02656797

Last Updated: 2022-03-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

13 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-01-30

Study Completion Date

2021-10-01

Brief Summary

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Comparison between placebo gel treatment to topical liposomal amphotericin B gel treatment for cutaneous leishmaniasis of Leishmania species major and tropica.

Detailed Description

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Randomized, double blind, placebo controlled study. The study will include 108 patients with cutenous leishmaniasis of Leishmania species major and tropica, confired by Polymerase Chain Reaction of a sample from a lesion.

Cure rate will be compared between patients treated with Amphotericin-B 0.4% Liposomal Gel and patients treated with placebo gel preparation.

Conditions

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Leishmaniasis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Study Groups

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AM-B

Topical Amphotericin-B 0.4% liposomal gel

Group Type EXPERIMENTAL

Topical Amphotericin-B 0.4% liposomal gel

Intervention Type DRUG

Topical Amphotericin-B 0.4% liposomal gel

Placebo

Placebo gel preparation

Group Type PLACEBO_COMPARATOR

Topical Amphotericin-B 0.4% liposomal gel

Intervention Type DRUG

Topical Amphotericin-B 0.4% liposomal gel

Interventions

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Topical Amphotericin-B 0.4% liposomal gel

Topical Amphotericin-B 0.4% liposomal gel

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Cutenous leishmaniasis confirmed by PCR (Leishmania species major or tropica)
* 1 to 5 lesions
* Signed informed consent

Exclusion Criteria

* Facial lesions
* Significant co-morbidity
* Pregnancy or breast-feeding at enrollment
* Previous treatment for leishmaniasis
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Soroka University Medical Center

OTHER

Sponsor Role lead

Responsible Party

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AMIR HOREV

Head, Pediatric dermatology Service, Soroka University Medical Center

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Amir Horev, MD

Role: PRINCIPAL_INVESTIGATOR

Soroka University Medical Center

Locations

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Soroka University Medical Center

Beersheba, , Israel

Site Status

Countries

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Israel

Other Identifiers

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sor017715ctil

Identifier Type: -

Identifier Source: org_study_id

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