External Physical Vibration Lithecbole Versus Traditional Row of Stone After Extracorporeal Shockwave Lithotripsy(ESWL)

NCT ID: NCT02643134

Last Updated: 2015-12-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

180 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-08-31

Study Completion Date

2016-07-31

Brief Summary

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The traditional stone row method comprises increasing exercise, drink lots of water, drug row of stone and stone row position. External physical vibration lithecbole(EPVL) is a non-invasive device active row of stone, the researchers hope that through this test prospective clinical study to evaluate the effectiveness of in vitro physical vibration row of stones after extracorporeal shockwave lithotripsy(ESWL) treatment of stones discharged, thereby improving after ESWL stone clearance rate.

Detailed Description

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To evaluate the efficacy and safety of external physical vibration lithecbole(EPVL) for the treatment after ESWL treatment of stones discharged,thereby improving after extracorporeal shockwave lithotripsy(ESWL) stone clearance rate. Investigators will do a multi-centers randomized controlled trial(RCT),and investigators plan to perform this study in 10 hospitals,which are the First Affiliated Hospital of Guangzhou Medical University of China, Department of Urology, The Second Affiliated Hospital of Zhengzhou University of China, Jiangsu Province Hospital, Hubei Province Hospital, Zhongshan Hospital, Tongji Hospital,Hubei provincial people's Hospital,Guilin 181 Hospital,the People' Hospital of Huzhou,The People' Hospital of Shaoyang.

Investigators plan to beginning their study August 2015 and end at July 2016. One hundred and eighty patients with ESWL postoperative residual stone will be enrolled in this study. By simple random sampling technique, all the patients will be assigned to the segment of natural stone row group or physical row of stone group, compared two groups of patients with stone clearance rate and complications, Investigators hope that through this test, improve stone clearance rate after ESWL.

Number:

180cases(90 cases in control group, 90 cases in EPVL group)

Grouping methods:

In this trial, investigators will use equilibrium randomization methods that generate random numerical code table, according to the table, patients are randomly assigned to different groups.

Evaluating indicator Stone-free rate in 4 weeks after ESWL. Incidence rate of complications and adverse reactions after EPVL(fever, hematuria, etc).

Trial method:

Examination before ESWL: blood routine, urine routine, renal function(Cre,BUN), coagulation function; intravenous pyelography(IVP) or CT (radiolucent calculus).

ESWL

Record: duration, frequency, voltage, times.

Method of control group(group1):

ESWL without EPVL; Reexamined by abdominal plain film(KUB) or CT (radiolucent calculus) right after ESWL;

After leaving hospital(without drugs), patients should follow the measures bellowed:

1. the amount of fluid intake is more than 2000ml/d
2. increase physical activity
3. rest in position on uninjured side, patients with lower renal calyx calculus need to invert body.

Method of EPVL group(group2):

Start the treatment of EPVL: the amount of fluid intake is about 1000-2000ml, start the treatment of EPVL when patent's bladder is filling; Reexamined by abdominal plain film(KUB) or CT(radiolucent calculus) right after EPVL;

Record: patients' date, treatment procedure and outcome;

After leaving hospital(without drugs), patients should follow the measures bellowed:

1. the amount of fluid intake is more than 2000ml/d
2. increase physical activity
3. rest in position on uninjured side, patients with lower renal calyx calculus need to invert body;

Follow up timing: return hospital respectively in 1,2 and 4 weeks after EPVL.

Follow up project Laboratory testing: routine urinalysis; Imaging examination: KUB or kidney CT scan (radiolucent calculus) Complications and adverse reactions. Data gathering Fill in follow up table data; Radiological images; IVP or kidney CT scan before ESWL; Reexamined by KUB (radiopaque calculus) or CT (radiolucent calculus) right after EPVL. If stones have been eliminated completely in patients with radiolucent calculus before or at the fourth week of follow-up, investigators must provide kidney CT scan.

Conditions

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Renal Calculi

Keywords

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ESWL EPVL PDI(Percussion,Diuresis,Inversion) Randomized Controlled Trial(RCT)

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Group 1

Patients in Group 1 undergo extracorporeal shockwave lithotripsy(ESWL).

Group Type OTHER

extracorporeal shockwave lithotripsy

Intervention Type PROCEDURE

Patients in Group 1 undergo extracorporeal shockwave lithotripsy(ESWL).

Group 2

Patients in Group 2 undergo external physical vibration lithecbole for the treatment after extracorporeal shockwave lithotripsy(ESWL).A multi-dimensional physical harmonic vibration inertial guidance technology

Group Type OTHER

External Physical Vibration Lithecbole

Intervention Type DEVICE

Multi-dimensional physical harmonic vibration inertial guidance technology

Interventions

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extracorporeal shockwave lithotripsy

Patients in Group 1 undergo extracorporeal shockwave lithotripsy(ESWL).

Intervention Type PROCEDURE

External Physical Vibration Lithecbole

Multi-dimensional physical harmonic vibration inertial guidance technology

Intervention Type DEVICE

Other Intervention Names

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Friend-I External Physical Vibration Lithecbole

Eligibility Criteria

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Inclusion Criteria

1. Age of 18-65 years;
2. The diameter of calculus is less than or equal to 15mm;
3. Renal or upper ureteral calculus;
4. There's no urinary tract obstruction below stones, and stones didn't cause complete urinary tract obstruction;
5. Stones are fragmented successfully on single session of ESWL, and the diameter of any of fragments is less than 6mm;
6. Normal renal function,

Exclusion Criteria

1. Couldn't tolerate EPVL;
2. Urinary tract anomalies, stricture or obstruction;
3. Calculus in diverticulum;
4. Severe hydronephosis;
5. Combined with acute urinary tract infection;
6. Coagulation abnormalities;
7. Morbid obesity(BMI\>35kg/m2);
8. Patients with ureteral stent;
9. Stones aren't fragment successfully, or the diameter of at least one fragment is more than 6mm ;
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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The First Affiliated Hospital of Guangzhou Medical University

OTHER

Sponsor Role lead

Responsible Party

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Guohua Zeng

Vice President of the Hospital

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Guohua Zeng, PH.D and M.D

Role: STUDY_CHAIR

The First Affiliated Hospital of Guangzhou Medical

Locations

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Department of Urology, Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University

Guangzhou, Guangdong, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Guohua Zeng, PH.D and M.D

Role: CONTACT

Phone: +86 13802916676

Email: [email protected]

Zhou Yang

Role: CONTACT

Phone: +86 13416129917

Email: [email protected]

Facility Contacts

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Guohua Zeng, Ph.D and M.D

Role: primary

Other Identifiers

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MRER(53)2015

Identifier Type: -

Identifier Source: org_study_id