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Plasma Biomarkers in Cardiac Valve Surgery

NCT ID: NCT02641665

Last Updated: 2017-10-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

250 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-01-31

Study Completion Date

2018-12-31

Brief Summary

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The level of four biomarkers will be measured in the patients' plasma after induction of anaesthesia. There biomarkers are NT-ProBNP, ST2, Galectin-3 and GDF-15. The level of these marker will then be correlated with early (30 days) and late (one year) patients' prognosis and with functional recovery (MLHFQ score).

Detailed Description

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Conditions

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Elective Valvular Cardiac Surgery

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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Cardiac valve surgery

Aortic or mitral valve replacement/repair performed in isolation of in addition to coronary artery bypass graft(s).

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Age ≥ 18 years
* Elective/urgent aortic or mitral valve surgery in isolation or combined with CABG

Exclusion Criteria

* Emergency or salvage surgery
* Inability to consent
* Previous cardiac surgery
* Stage IV or V CDK (GFR ≤ 30 ml/min) or dialysis
* Active Endocarditis
* Liver cirrhosis
* Chronic atrial fibrillation
* Pacemaker
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Liege

OTHER

Sponsor Role lead

Responsible Party

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Jean François Brichant

Professor, Head of Department

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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CHU of Liege

Liège, , Belgium

Site Status RECRUITING

Countries

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Belgium

Central Contacts

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Gregory A Hans, MD, PhD

Role: CONTACT

[email protected]
+3243667655

Facility Contacts

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Gregory A Hans, MD, PhD

Role: primary

[email protected]
+3243667655

Other Identifiers

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2016001

Identifier Type: -

Identifier Source: org_study_id