Biochemical Alterations of Stored Erythrocyte Membranes

NCT ID: NCT02639780

Last Updated: 2022-01-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

36 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-12-31

Study Completion Date

2021-12-31

Brief Summary

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The investigators will define procoagulant properties of packed red blood cells and investigate whether packed red blood cells from certain donor populations are prone to induce procoagulant states.

Detailed Description

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Conditions

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Coagulation

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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healthy young female

protein expression pattern of packed red blood cells

Intervention Type OTHER

the proteome of packed red blood cells will be assessed at predefined time points

healthy young male

protein expression pattern of packed red blood cells

Intervention Type OTHER

the proteome of packed red blood cells will be assessed at predefined time points

healthy older female

protein expression pattern of packed red blood cells

Intervention Type OTHER

the proteome of packed red blood cells will be assessed at predefined time points

healthy older male

protein expression pattern of packed red blood cells

Intervention Type OTHER

the proteome of packed red blood cells will be assessed at predefined time points

obese older female

protein expression pattern of packed red blood cells

Intervention Type OTHER

the proteome of packed red blood cells will be assessed at predefined time points

obese older male

protein expression pattern of packed red blood cells

Intervention Type OTHER

the proteome of packed red blood cells will be assessed at predefined time points

Interventions

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protein expression pattern of packed red blood cells

the proteome of packed red blood cells will be assessed at predefined time points

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* group 1: healthy female volunteers 18-35 y.o.
* group 2: healthy male volunteers 18-35 y.o.
* group 3: healthy female volunteers 36-60 y.o.
* group 4: healthy male volunteers 36-60 y.o.
* group 5: female volunteers 36-60 y.o., BMI 26-45
* group 6: male volunteers 36-60 y.o., BMI 26-45

Exclusion Criteria

* age below 18 years
* age above 60 years
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Medical Scientific Fund of the Mayor of Vienna

OTHER

Sponsor Role collaborator

European Society of Anaesthesiology

OTHER

Sponsor Role collaborator

Medical University of Vienna

OTHER

Sponsor Role lead

Responsible Party

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David M Baron, MD

Assistant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Medical University of Vienna

Vienna, , Austria

Site Status

Countries

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Austria

Other Identifiers

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1043/2015

Identifier Type: -

Identifier Source: org_study_id

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