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Peripheral Nerve Blocks in Elderly Patients With Hip Fracture

NCT ID: NCT02635763

Last Updated: 2015-12-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-10-31

Study Completion Date

2016-06-30

Brief Summary

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As the population ages, the frequency of surgery is increasing proportionally, bringing with it the challenge of managing older patients with frequent comorbid diseases and an increased risk of complications. Poor postoperative quality of recovery may result in patient and family suffering, a prolonged hospital stay, and a greater demand on health care resources.The purpose of this study was to evaluate the ultrasound guided percutaneous femoral nerve+lateral cutaneous nerve versus lumbar plexus+sacral plexus nerve block composite laryngeal mask anesthesia in elderly hip fracture surgery, the application of assessing their impact on the postoperative recovery quality.

Detailed Description

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In this study, patients who were more than 65 years old with hip fracture were randomized to peripheral nerve blocks 1(PNBs1)- femoral nerve+lateral cutaneous nerve-with laryngeal mask anesthesia, or peripheral nerve blocks 2(PNBs2) - lumbar plexus and sciatic - with laryngeal mask anesthesia. Blocks were performed using ultrasound and 0.5% ropivacaine. All patients received postoperative multimodal analgesia. Postoperative recovery was assessed at 15 minutes, 40 minutes,- 1 day, 3 days, and 7 days after surgery, with the Postoperative Quality of Recovery Scale, in physiological, nociceptive, emotive, modified activities of daily living, modified cognitive, and overall patient perspective domains.

Conditions

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Hip Fracture

Keywords

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nerve block general anesthesia hip fracture recovery

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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PNBs1

Femoral nerve and the lateral cutaneous nerve block combined with general anesthesia

Group Type OTHER

Femoral nerve and the lateral cutaneous nerve block

Intervention Type PROCEDURE

Femoral nerve block was performed using 0.5% ropivacaine (15ml) under ultrasound guide;the lateral cutaneous nerve block was performed using 0.5% ropivacaine (5ml) under ultrasound guide

PNBs2

Lumbar plexus and sacral plexus nerve block combined with general anesthesia

Group Type OTHER

Lumbar plexus and sacral plexus nerve block

Intervention Type PROCEDURE

Lumbar plexus block was performed using 0.5% ropivacaine (25ml) under ultrasound guide; sacral plexus nerve block was performed using 0.5% ropivacaine (15ml) under ultrasound guide

Interventions

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Femoral nerve and the lateral cutaneous nerve block

Femoral nerve block was performed using 0.5% ropivacaine (15ml) under ultrasound guide;the lateral cutaneous nerve block was performed using 0.5% ropivacaine (5ml) under ultrasound guide

Intervention Type PROCEDURE

Lumbar plexus and sacral plexus nerve block

Lumbar plexus block was performed using 0.5% ropivacaine (25ml) under ultrasound guide; sacral plexus nerve block was performed using 0.5% ropivacaine (15ml) under ultrasound guide

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

1. ASA grade I \~ III level;
2. The BMI \<30;
3. The Mini - getting the state examination MMSE \> 23;
4. The operation type:open reduction and internal fixation or bipolar head replace.

Exclusion Criteria

1. Serious systemic diseases such as respiratory dysfunction, cardiac insufficiency, and renal insufficiency;
2. Has a history of cognitive function disorder or mental illness;
3. Has a history of cerebral infarction and leave sequela;
4. The blood coagulation dysfunction;
5. The hearing or visual impairment;
6. Unable to complete assessment;
7. Operation time more than 90 minutes;
8. The bleeding is greater than 1000 ml.
Minimum Eligible Age

65 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Shanghai Jiao Tong University Affiliated Sixth People's Hospital

OTHER

Sponsor Role lead

Responsible Party

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Qingfu Zhang

Shanghaii Sixth People's Hospital

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Junfeng Zhang, PhD

Role: STUDY_DIRECTOR

Department of Anesthesiology, Shanghai Jiao Tong University Affiliated Shanghai Sixth People's Hospital

Locations

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Shanghai Jiao Tong University Affiliated Shanghai Sixth People's Hospital

Shanghai, Shanghai Municipality, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Qingfu Zhang, master

Role: CONTACT

Phone: 86-18930173672

Email: [email protected]

Junfeng Zhang, PhD

Role: CONTACT

Phone: 86-18930173672

Email: [email protected]

References

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Urwin SC, Parker MJ, Griffiths R. General versus regional anaesthesia for hip fracture surgery: a meta-analysis of randomized trials. Br J Anaesth. 2000 Apr;84(4):450-5. doi: 10.1093/oxfordjournals.bja.a013468.

Reference Type BACKGROUND
PMID: 10823094 (View on PubMed)

Abou-Setta AM, Beaupre LA, Rashiq S, Dryden DM, Hamm MP, Sadowski CA, Menon MR, Majumdar SR, Wilson DM, Karkhaneh M, Mousavi SS, Wong K, Tjosvold L, Jones CA. Comparative effectiveness of pain management interventions for hip fracture: a systematic review. Ann Intern Med. 2011 Aug 16;155(4):234-45. doi: 10.7326/0003-4819-155-4-201108160-00346.

Reference Type BACKGROUND
PMID: 21844549 (View on PubMed)

Liu J, Yuan W, Wang X, Royse CF, Gong M, Zhao Y, Zhang H. Peripheral nerve blocks versus general anesthesia for total knee replacement in elderly patients on the postoperative quality of recovery. Clin Interv Aging. 2014 Feb 18;9:341-50. doi: 10.2147/CIA.S56116. eCollection 2014.

Reference Type BACKGROUND
PMID: 24600214 (View on PubMed)

Other Identifiers

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NB001

Identifier Type: -

Identifier Source: org_study_id