Transitional Growth Hormone (GH) Use in Growth Hormone Deficient (GHD) Cancer Survivors

NCT ID: NCT02629926

Last Updated: 2015-12-15

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 60 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2010-10-31

Brief Summary

Cure rates for childhood malignancies have improved at a remarkable pace.With the increasing cure rate came recognition of the long-term detrimental effects of radiotherapy and chemotherapy, known as "late-effects". Endocrine late-effects are particularly prevalent in childhood cancer survivors. Growth Hormone (GH) deficiency is common following radiation to the head and leads to impaired growth, hence GH replacement is given to achieve optimise final height in childhood. In the adult GH is important to maintenance of bone, muscle & fat mass; vascular risk factors; and quality of life. This observational study aims to determine the long-term effect of low dose GH replacement on development of bone, muscle and fat mass; vascular risk; and quality of life in the early years after achievement of final height, a time known as "transition". GH is thought to be essential to development of bone, muscle, and fat mass during this time period.

Patients will be identified in the late -effects endocrine clinic, aged 16-22yrs, who are severely GH deficient. 30 patients will be recruited to the study who wish to continue receiving GH replacement, all of whom will receive recombinant GH. An additional 30 patients who do not wish to receive GH replacement will provide a parallel control data.

All patients will undergo baseline assessment including examination; routine blood tests; urine dipstick; measures on height, weight, waist, and 24 hour blood pressure. Measures will be repeated at six months, and then annually until 25 years of age. Bone density will be measured at baseline, after two years and at age 25yrs. Patients requesting GH replacement will require initial additional visits to teach self injection, then 2-4wkly to assess when correct dose of GH is achieved. The study will enable assessment of the beneficial effects of GH replacement during transition in GH deficient survivors of cancer to be realised.

Conditions

Metabolic Diseases; Cancer

Study Design

• Observational Model Type: CASE_ONLY
• Study Time Perspective: PROSPECTIVE

Study Groups

Patients to receive GH replacement

30 patients will be recruited to the study who wishes to continue receiving growth hormone replacement, all of whom will receive NutorpinAq Recombinant growth hormone

GH Replacement (NutropinAq®)

Intervention Type: OTHER

GH Replacement continued.

Patients who will not receive GH replacement

An additional 30 patients who elect not to receive growth hormone replacement will provide a parallel control data.

No additional treatment

Intervention Type: OTHER

GH Replacement not continued.

Interventions

GH Replacement (NutropinAq®)

GH Replacement continued.

Intervention Type: OTHER

No additional treatment

GH Replacement not continued.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Aged 16--22 years inclusive.
• Both genders.
• Able to provide informed consent.
• Severe GH deficiency (peak GH<5mcg/l on stimulation).
• No GH replacement therapy during the three months preceding the baseline visit.
• Stable anterior pituitary hormone (i.e. sex steroids, hydrocortisone, thyroxine) therapy over the previous six months.
• Life expectancy >24 months.

Exclusion Criteria

• Acute critical illness (Patients suffering complications following open heart surgery, abdominal surgery, multiple accidental trauma, acute respiratory failure, or similar conditions).
• Active malignant disease (i.e. undergoing active treatment or palliation).
• Patients treated for an intracranial malignancy should have completed therapy two years prior to entering the study.
• Active Cushing's disese or acromegaly
• Pregnancy or desire to conceive within the following year. Patients at risk of pregnancy will be screened by urine pregnancy (HCG) test at the baseline evaluation & treatment initiation visit.
• Breast feeding.
• Proliferative diabetic retinopathy.
• Sensitivity to GH or its preservative

• Minimum Eligible Age: 16 Years
• Maximum Eligible Age: 22 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

The Leeds Teaching Hospitals NHS Trust

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

The Leeds Teaching Hospitals NHS Trust

Leeds, , United Kingdom

Site Status: RECRUITING

Countries

United Kingdom

Facility Contacts

R&I Administrator

Role: primary

Other Identifiers

ED07/8440

Identifier Type: -

Identifier Source: org_study_id