Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
30 participants
OBSERVATIONAL
2016-01-19
2022-03-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Research Participants
Medical history questionnaire; clinical assessment and review; participant follow-up; blood or buccal sample; post mortem examination.
Medical history questionnaire
Epidemiological review of past medical/dental history; residential history; occupational history; family history of neurodegenerative disease.
Clinical assessment and review
History of current illness; neurological examination including general appearance, full cognitive assessment and physical examination; MRI research brain scan.
Participant follow-up
Hospital patient management system; regular telephone contact with patient/representative.
Blood or buccal sample
Codon-129 genotyping; storage for future research.
Post mortem examination
Brain tissue donation to the Edinburgh Brain and Tissue Bank for research,including investigations for evidence of prion disease.
Interventions
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Medical history questionnaire
Epidemiological review of past medical/dental history; residential history; occupational history; family history of neurodegenerative disease.
Clinical assessment and review
History of current illness; neurological examination including general appearance, full cognitive assessment and physical examination; MRI research brain scan.
Participant follow-up
Hospital patient management system; regular telephone contact with patient/representative.
Blood or buccal sample
Codon-129 genotyping; storage for future research.
Post mortem examination
Brain tissue donation to the Edinburgh Brain and Tissue Bank for research,including investigations for evidence of prion disease.
Eligibility Criteria
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Inclusion Criteria
* Patients accessing NHS Lothian neurology and psychogeriatric services
* Patients who have features atypical for the recognised forms of dementia
* Appropriate informed consent
Exclusion Criteria
* Patients diagnosed with a clear alternative demonstrable pathology
65 Years
ALL
No
Sponsors
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NHS Lothian
OTHER_GOV
Department of Health, United Kingdom
OTHER_GOV
University of Edinburgh
OTHER
Responsible Party
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Principal Investigators
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Anna M Molesworth, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Edinburgh
Locations
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CJD Research and Surveillance Unit, Western General Hospital
Edinburgh, , United Kingdom
Countries
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Other Identifiers
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15/SS/0196
Identifier Type: -
Identifier Source: org_study_id
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