Promoting Weight Loss Through Diet and Exercise in Overweight Women With Breast Cancer

NCT ID: NCT02622711

Last Updated: 2020-01-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

262 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-11-30

Study Completion Date

2019-06-30

Brief Summary

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The investigators aim to evaluate the effect of a 6-month intervention (counseling) focused on weight loss in a group of overweight or obese women previously treated for early breast cancer. Intervention is designed to improve adherence to a healthy diet or/and to increase physical activity and decrease sedentary time, taking advantage of a pedometer-like device.

Detailed Description

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The InForma project is designed as a mono-institutional randomized controlled 4-arm parallel-group trial. Potential study participants will be recruited among all overweight or obese breast cancer patients previously treated at the European Institute of Oncology (IEO). Potential study participants will be recruited after breast cancer treatments (surgery, chemotherapy and and/or radiation) will be completed. Study participants will be randomized to one of the 4 arms: DI - Dietary Intervention; PAI - Physical Activity Intervention; PADI - Physical Activity and Dietary Intervention; LII - Less Intensive Intervention. Enrolled patients will receive a 6-month intervention and will be followed until the end of the study period with two additional follow-up visits at 12- and 24-month. The main aim of the study is to evaluate the impact of the intervention programme on body weight change in overweight or obese breast cancer patients.

Conditions

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Breast Cancer

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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DI Dietary Intervention

Individualized dietary counselling to reduce body weight

Group Type EXPERIMENTAL

DI

Intervention Type BEHAVIORAL

Participants will be offered an individualized dietary counselling according to their lifestyle habits to reduce weight consisting of face-to face contacts, group meetings, motivational phone calls and information pamphlets.

PAI Physical Activity Intervention

Individualized physical activity counseling to reduce body weight

Group Type EXPERIMENTAL

PAI

Intervention Type BEHAVIORAL

Participants will be offered an individualized physical activity counseling according to their lifestyle habits to reduce weight consisting of face-to face contacts, group meetings, motivational phone calls and information pamphlets.

PADI Physical Activity+Diet Intervention

Individualized dietary and physical activity counseling to reduce body weight

Group Type EXPERIMENTAL

PADI

Intervention Type BEHAVIORAL

Participants will be offered an individualized dietary and physical activity counseling to reduce weight consisting of face-to face contacts, group meetings, motivational phone calls and information pamphlets.

LII Less Intensive Intervention

Materials and guidelines available to general public

Group Type EXPERIMENTAL

LII

Intervention Type BEHAVIORAL

Participants will be considered as control group. They will receive a general healthy counselling providing materials and guidelines available for the general public.

Interventions

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DI

Participants will be offered an individualized dietary counselling according to their lifestyle habits to reduce weight consisting of face-to face contacts, group meetings, motivational phone calls and information pamphlets.

Intervention Type BEHAVIORAL

PAI

Participants will be offered an individualized physical activity counseling according to their lifestyle habits to reduce weight consisting of face-to face contacts, group meetings, motivational phone calls and information pamphlets.

Intervention Type BEHAVIORAL

PADI

Participants will be offered an individualized dietary and physical activity counseling to reduce weight consisting of face-to face contacts, group meetings, motivational phone calls and information pamphlets.

Intervention Type BEHAVIORAL

LII

Participants will be considered as control group. They will receive a general healthy counselling providing materials and guidelines available for the general public.

Intervention Type BEHAVIORAL

Other Intervention Names

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Dietary Intervention Physical Activity Intervention Physical Activity and Dietary Intervention Less Intensive Intervention

Eligibility Criteria

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Inclusion Criteria

* diagnosed with a first invasive non-metastatic breast carcinoma histologically confirmed,
* BMI \> 25,
* within 6-month/one year of completion of main cancer treatment,
* being able to participate in the intervention,
* agree to wear the wrist-based activity monitor during the study period,
* agree to be randomized to either group,
* written informed consent.

Exclusion Criteria

* severe medical condition or advanced age impeding the patient to adhere at the planned study follow-up period,
* contraindications to exercise due to history of heart condition, stroke, chest pain during activity or rest, severe hypertension
* orthopaedic disability that would prevent optimal participation in the physical activities prescribed,
* patient is unable to find transportation to the study location over the study period, - or
* plans to move away from Lombardy or to be out of town for more than 3 weeks during the study period.
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Associazione Italiana per la Ricerca sul Cancro

OTHER

Sponsor Role collaborator

European Institute of Oncology

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Patrick Maisonneuve

Role: PRINCIPAL_INVESTIGATOR

European Institue of Oncology

Locations

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IEO Istituto Europeo di Oncologia

Milan, , Italy

Site Status

Countries

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Italy

References

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Gnagnarella P, Carioni G, Draga D, Raja S, Baggi F, Simoncini MC, Mazzocco K, Masiero M, Bassi FD, Peradze N, Zorzino L, Pravettoni G, Sieri S, Maisonneuve P. Dietary patterns and change in food consumption in overweight or obese breast cancer survivors: the InForma randomized intervention trial. Nutr Metab Cardiovasc Dis. 2025 Oct 16:104378. doi: 10.1016/j.numecd.2025.104378. Online ahead of print.

Reference Type DERIVED
PMID: 41145327 (View on PubMed)

Gnagnarella P, Draga D, Baggi F, Simoncini MC, Sabbatini A, Mazzocco K, Bassi FD, Pravettoni G, Maisonneuve P. Promoting weight loss through diet and exercise in overweight or obese breast cancer survivors (InForma): study protocol for a randomized controlled trial. Trials. 2016 Jul 28;17:363. doi: 10.1186/s13063-016-1487-x.

Reference Type DERIVED
PMID: 27464488 (View on PubMed)

Other Identifiers

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IEO 0244

Identifier Type: -

Identifier Source: org_study_id

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