Evaluation of High Speed Laser Doppler Imaging Technology
NCT ID: NCT02619331
Last Updated: 2015-12-02
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
50 participants
INTERVENTIONAL
2008-02-29
2011-09-30
Brief Summary
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This study aims to evaluate the quantification of SPT by a novel High Speed Laser Doppler Imaging (HSL-DI) and to compare it with CWFM. First, SPT with birch and/or grass pollen extracts as well as positive and negative controls will be performed in 20 volunteers (11 atopics, 9 non-atopics) to establish the characteristics (cut-off, optimal reading time and allergen concentration) of HSL-DI analysis based on two parameters ("area" and "flow" measurement). In a second step, fifty patients will be tested with birch and grass pollen extracts at optimal allergen concentration and time window. Analysis of SPT by HSL-DI and CWFM will be compared.
Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
DIAGNOSTIC
NONE
Study Groups
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Atopic volunteers
Allergy tests will be performed in allergic patients with rhinoconjunctivitis and allergy test reading measured following two different methodologies. 1) test reading based on conventional wheal and flare measurement (wheal diameter in mm, CWFM), 2) test reading based on high speed laser doppler imaging (HS-LDI). Both type of tests reading will be compared.
Allergy test reading
Reading of allergy skin tests (in response to allergen extracts or histamine or negative control) by HSL-DI versus direct observer evaluation (CWFM)
Interventions
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Allergy test reading
Reading of allergy skin tests (in response to allergen extracts or histamine or negative control) by HSL-DI versus direct observer evaluation (CWFM)
Eligibility Criteria
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Inclusion Criteria
* history of allergic rhinitis to birch pollen and/or grass pollen.
Exclusion Criteria
* uncontrolled asthma (peak expiratory "flow" \<80% of volunteer's best personal value)
* treatment with antihistamine medication less than two weeks before enrolment or during the trial.
18 Years
65 Years
ALL
Yes
Sponsors
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Centre Hospitalier Universitaire Vaudois
OTHER
Responsible Party
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François Spertini
Associate Prof.
Principal Investigators
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François Spertini, MD
Role: PRINCIPAL_INVESTIGATOR
CHUV
Locations
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CHUV , Division of Immunology and Allergy
Lausanne, , Switzerland
Countries
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Other Identifiers
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HSL-DI
Identifier Type: -
Identifier Source: org_study_id