Characterization of Phenotype and Genotype of Early Onset Enteropathies

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

1445 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-06-16

Study Completion Date

2054-06-15

Brief Summary

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This study has been set up in order to characterize phenotypes and genotypes of patients with early onset enteropathies.

In that goal, Investigators will collect biological samples (mainly blood) of patients suffering from early onset enteropathies and their healthy relatives.

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Detailed Description

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This study specifically aims at the genetic analysis of early onset enteropathies with the goal in mind to delineate human pathways necessary to maintain intestinal homeostasis despite the considerable density of microbes colonizing the distal part of the human intestine.

Conditions

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Inflammatory Bowel Disease

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Sick patients

Biological sampling of blood for all patients. Biological sampling of saliva, biopsies (skin and endoscopic), feces, for some patients

Biological sampling

Intervention Type OTHER

Biological sampling including blood, feces, biopsies...

Healthy relatives

Biological sampling of blood for all healthy relatives

Biological sampling

Intervention Type OTHER

Biological sampling including blood, feces, biopsies...

Interventions

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Biological sampling

Biological sampling including blood, feces, biopsies...

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Severe chronic enteropathy
* Patients developing their first symptoms within the first 6 years of life and, in priority within the first two years of life, or patients with a disease of later onset, in case of a familial history suggestive of inherited mutations notably in families comprising several affected members
* OR : Be a patient's relative, even if presenting with enteropathy of later onset.