Trial to Evaluate the Efficacy and Safety of Nitazoxanide in the Treatment of Acute Uncomplicated Influenza
NCT ID: NCT02612922
Last Updated: 2018-04-04
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE3
325 participants
INTERVENTIONAL
2015-12-31
2016-09-04
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
TRIPLE
Study Groups
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Nitazoxanide
Two Nitazoxanide 300 mg tablets orally twice daily (b.i.d.) for 5 days
Nitazoxanide
Nitazoxanide 600 mg administered orally twice daily for five days
Placebo
Two Placebo tablets orally twice daily (b.i.d.) for 5 days
Placebo
Placebo administered orally twice daily for five days
Interventions
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Nitazoxanide
Nitazoxanide 600 mg administered orally twice daily for five days
Placebo
Placebo administered orally twice daily for five days
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
2. Presence of clinical signs and/or symptoms consistent with an acute illness compatible with influenza infection (each of the following is required):
* oral temperature of ≥100.4°F or ≥38°C (obtained in office or self-measured within 12 hours prior to screening - if self-measured, subject must also have taken an antipyretic within 4 hours prior to screening) AND
* at least one of the following respiratory symptoms (cough, sore throat, nasal obstruction), AND
* one of the following constitutional symptoms (fatigue, headache, myalgia, feverishness).
3. Confirmation of influenza A or B infection in the local community by one of the following means:
* the institution's local laboratory,
* the local public health system,
* the national public health system, or
* a laboratory of a recognized national or multinational influenza surveillance scheme.
4. Onset of illness no more than 40 hours before enrollment in the trial.
Note: Time of onset of illness is defined as either the earlier of:
* the time when the temperature was first measured as elevated, OR
* the time when the subject experienced the presence of at least one respiratory symptom AND the presence of at least one constitutional symptom.
5. Willing and able to provide written informed consent (including assent by legal guardian if under 18 years of age) and comply with the requirements of the protocol, including completion of the patient diary.
Exclusion Criteria
* Persons with asthma or other chronic pulmonary diseases, such as cystic fibrosis in children or chronic obstructive pulmonary disease in adults.
* Persons with hemodynamically significant cardiac disease.
* Persons who have immunosuppressive disorders or who are receiving immunosuppressive therapy.
* Human Immunodeficiency Virus (HIV) infected persons.
* Persons with sickle cell anemia or other hemoglobinopathies.
* Persons with diseases requiring long-term aspirin therapy, such as rheumatoid arthritis or Kawasaki disease.
* Persons with chronic renal dysfunction.
* Persons with liver disorders.
* Persons with active cancer.
* Persons with chronic metabolic disease, such as diabetes mellitus, inherited metabolic disorders and mitochondrial disorders.
* Persons with neuromuscular disorders, seizure disorders or cognitive dysfunction that may compromise the handling of respiratory secretions.
* Residents of any age of nursing homes or other long-term care institutions.
* Persons who are morbidly obese (Body Mass Index ≥40).
* American Indians.
* Alaskan natives.
2. Females of childbearing potential who are either pregnant, breast-feeding or are sexually active without the use of birth control. Female subjects of child-bearing potential that are sexually active must have a negative baseline pregnancy test and must agree to continue an acceptable method of birth control for the duration of the study and for 1 month post-treatment. A double barrier method, oral birth control pills administered for at least 2 monthly cycles prior to study drug administration, an intrauterine device (IUD), or medroxyprogesterone acetate administered intramuscularly for a minimum of one month prior to study drug administration are acceptable methods of birth control for inclusion into the study. Female subjects are considered of childbearing potential unless they are postmenopausal (absence of menstrual bleeding for 1 year - or 6 months if laboratory confirmation of hormonal status), or have had a hysterectomy, bilateral tubular ligation or bilateral ovariectomy.
3. Vaccination for seasonal influenza on or after August 1, 2015.
4. Receipt of any dose of nitazoxanide, oseltamivir, zanamivir, peramivir, amantadine or rimantadine within 30 days prior to screening.
5. Prior treatment with any investigational drug therapy within 30 days prior to screening.
6. Subjects with active respiratory allergies or subjects expected to require anti-allergy medications during the study period for respiratory allergies.
7. Known sensitivity to nitazoxanide or any of the excipients comprising the nitazoxanide tablets.
8. Subjects unable to take oral medications.
9. Subject has chronic kidney or liver disease (including Hepatitis A, B or C) or known impaired hepatic and/or renal function.
10. Presence of any other pre-existing chronic infection that is undergoing or requiring medical therapy.
11. Presence of any pre-existing illness that, in the opinion of the Investigator, would place the subject at an unreasonably increased risk through participation in this study.
12. Subjects who, in the judgment of the Investigator, will be unlikely to comply with the requirements of this protocol.
12 Years
65 Years
ALL
No
Sponsors
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Romark Laboratories L.C.
INDUSTRY
Responsible Party
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Principal Investigators
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Jean-Francois Rossignol, M.D., Ph.D.
Role: STUDY_DIRECTOR
Romark Laboratories L.C.
Locations
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Influence Study Site
Hot Springs, Arkansas, United States
Influence Study Site
Anaheim, California, United States
Influence Study Site
Fresno, California, United States
Influence Study Site
Lomita, California, United States
Influence Study Site
Kissimmee, Florida, United States
Influence Study Site
Lauderdale Lakes, Florida, United States
Influence Study Site
Saint Cloud, Florida, United States
Influence Study Site
Columbus, Georgia, United States
Influence Study Site
Savannah, Georgia, United States
Influence Study Site
Lansdale, Pennsylvania, United States
Influence Study Site
Rapid City, South Dakota, United States
Influence Study Site
Jackson, Tennessee, United States
Influence Study Site
Austin, Texas, United States
Influence Study Site
Houston, Texas, United States
Influence Study Site
Pharr, Texas, United States
Influence Study Site
Plano, Texas, United States
Influence Study Site
Waco, Texas, United States
Influence Study Site
Brookvale, New South Wales, Australia
Influence Study Site
Castle Hill, New South Wales, Australia
Influence Study Site
Mosman, New South Wales, Australia
Influence Study Site
Browns Plains, Queensland, Australia
Influence Study Site
Springfield, Queensland, Australia
Influence Study Site
Berwick, Victoria, Australia
Influence Study Site
Lynbrook, Victoria, Australia
Influence Study Site
Rosebud, Victoria, Australia
Influence Study Site
Tarneit, Victoria, Australia
Influence Study Site
San Juan, , Puerto Rico
Influence Study Site
San Juan, , Puerto Rico
Countries
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Other Identifiers
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RM08-3003
Identifier Type: -
Identifier Source: org_study_id
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