CT Indexes of Emphysema and Airways in Healthy Volunteers: Normal Values; Relations With Gender, Height and Weight
NCT ID: NCT02611947
Last Updated: 2015-11-23
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
87 participants
OBSERVATIONAL
2010-10-31
2011-06-30
Brief Summary
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Detailed Description
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1. On chest CT scans, indexes reflecting pulmonary emphysema and airways measurements have been computed by using dedicated softwares. Each of our three readers performed two reading sessions.
Relative area of lung parenchyma with attenuation value less than -960 Hounsfield Units; luminal area and wall thickness in third and fourth generations airways were recorded.
2. Pulmonary function tests were performed: vital capacity, forced vital capacity , functional residual capacity, total lung capacity, residual volume, forced expiratory volume in one second, and diffusion lung capacity for carbon monoxide were recorded (either in absolute values and percentage of predicted values).
CT indexes were compared with gender, height and weight.
Conditions
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Study Design
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CASE_ONLY
PROSPECTIVE
Study Groups
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Healthy Volunteers
Inclusion criteria:
1. Aged 18 or more.
2. Never smoked.
3. No respiratory infection in the 4 weeks before the begin of the study.
4. No history of pulmonary resection.
5. No active malignancy or malignancy of any organ system within the past 5 years.
Low-dose chest CT scans
Supine chest CT scan after full inspiration. Acquisition parameters: (Topogram 35 mA 120 kV 512 mm length)
35 quality ref mAs with care-dose ON 120 kV Pitch 1.4 Rotation time 0.33 s Acquired images 64 x 0.6 mm
Interventions
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Low-dose chest CT scans
Supine chest CT scan after full inspiration. Acquisition parameters: (Topogram 35 mA 120 kV 512 mm length)
35 quality ref mAs with care-dose ON 120 kV Pitch 1.4 Rotation time 0.33 s Acquired images 64 x 0.6 mm
Eligibility Criteria
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Inclusion Criteria
* No respiratory infection in the 4 weeks before the begin of the study.
* No history of pulmonary resection.
* No active malignancy or malignancy of any organ system within the past 5 years.
18 Years
ALL
Yes
Sponsors
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Erasme University Hospital
OTHER
Responsible Party
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Principal Investigators
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Pierre Alain GEVENOIS, MD, PhD
Role: STUDY_DIRECTOR
Erasme University Hospital
Locations
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Erasme University Hospital
Brussels, Brussels Capital, Belgium
Countries
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References
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Madani A, Zanen J, de Maertelaer V, Gevenois PA. Pulmonary emphysema: objective quantification at multi-detector row CT--comparison with macroscopic and microscopic morphometry. Radiology. 2006 Mar;238(3):1036-43. doi: 10.1148/radiol.2382042196. Epub 2006 Jan 19.
Madani A, De Maertelaer V, Zanen J, Gevenois PA. Pulmonary emphysema: radiation dose and section thickness at multidetector CT quantification--comparison with macroscopic and microscopic morphometry. Radiology. 2007 Apr;243(1):250-7. doi: 10.1148/radiol.2431060194.
Hackx M, Bankier AA, Gevenois PA. Chronic obstructive pulmonary disease: CT quantification of airways disease. Radiology. 2012 Oct;265(1):34-48. doi: 10.1148/radiol.12111270.
Hackx M, Gyssels E, Severo Garcia T, De Meulder I, Alard S, Bruyneel M, Van Muylem A, Ninane V, Gevenois PA. Chronic Obstructive Pulmonary Disease: CT Quantification of Airway Dimensions, Numbers of Airways to Measure, and Effect of Bronchodilation. Radiology. 2015 Dec;277(3):853-62. doi: 10.1148/radiol.2015140949. Epub 2015 May 19.
Other Identifiers
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P2010/175
Identifier Type: -
Identifier Source: org_study_id