RSPR-007 Mannitol Challenge Trial

NCT ID: NCT02609334

Last Updated: 2016-11-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

24 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-03-31

Study Completion Date

2015-07-31

Brief Summary

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This is a double-blind, randomised, placebo-controlled, cross-over, Phase 2 trial evaluating two doses (a low and a high) of CRD007 for the treatment of asthmatic trial subjects with a positive asthma test (mannitol challenge) prior to enrolment.

Detailed Description

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The present trial will include subjects with diagnosed asthma in a provocation model which mimics assessments of asthma control. Mannitol challenge is an indirect asthma provocation test, which requires the presence of inflammatory cells, particularly mast cells, in the airways.

The trial involved in total 5 subject visits and will last for a maximum of 30 days for each subject from Visit 2 (Randomisation) to Visit 5 (Follow up).

Visit 2,3, and 4 will be treatment visits where Investigational Medicinal Product (IMP) is administrated 3 hours before the Mannitol challenge.

Conditions

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Asthma

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Placebo

Matching placebo tables are given as a single dose

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type OTHER

One single dose given 3 hours prior to Mannitol challenge

CRD007 Low dose

"Low dose" of CRD007 (pemirolast sodium) given as a single dose

Group Type ACTIVE_COMPARATOR

CRD007

Intervention Type DRUG

One single dose given 3 hours prior to Mannitol challenge

CRD007 High dose

"High dose" CRD007 (pemirolast sodium) given as a single dose

Group Type ACTIVE_COMPARATOR

CRD007

Intervention Type DRUG

One single dose given 3 hours prior to Mannitol challenge

Interventions

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CRD007

One single dose given 3 hours prior to Mannitol challenge

Intervention Type DRUG

Placebo

One single dose given 3 hours prior to Mannitol challenge

Intervention Type OTHER

Other Intervention Names

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Pemirolast sodium

Eligibility Criteria

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Inclusion Criteria

* Written informed consent
* Age ≥18 and \<50 years
* Diagnosis of asthma

Exclusion Criteria

* Clinical significant comorbidities
* Lower respiratory tract infection \<6 weeks prior to Visit 1
* Others, as specified in the protocol
Minimum Eligible Age

18 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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RSPR Pharma AB

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Vibeke Backer, MD

Role: PRINCIPAL_INVESTIGATOR

Bispebjerg Hospital

Locations

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Hvidovre Hospital

Hvidovre, , Denmark

Site Status

Bisbebjerg Hospital

København NV, , Denmark

Site Status

Countries

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Denmark

Other Identifiers

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RSPR-007

Identifier Type: -

Identifier Source: org_study_id