Non-Interventional Post-Marketing Safety Study on the Long-Term Safety of HYQVIA (Global)

NCT ID: NCT02593188

Last Updated: 2022-10-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

264 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-11-12

Study Completion Date

2021-10-21

Brief Summary

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The purpose of the proposed study is to acquire additional data (including the assessment of anti-rHuPH20 antibodies) on the long-term safety of HYQVIA and to assess the prescribed treatment regimens and treatment administration in routine clinical practice.

Detailed Description

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Conditions

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Primary Immunodeficiency Diseases (PID)

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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HYQVIA- Epoch 1

Participants receiving HYQVIA

HYQVIA

Intervention Type BIOLOGICAL

Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase

HYQVIA- Epoch 2

Participants with rHuPH antibody titers ≥160 (tested in Epoch 1)

HYQVIA

Intervention Type BIOLOGICAL

Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase

Interventions

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HYQVIA

Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

1. Participant requires immunoglobulin treatment for primary immunodeficiency disease (PIDD)
2. Participant age is compatible with local package insert requirements
3. Participant has been prescribed or has started treatment with HYQVIA (Immune Globulin (Human) 10% with rHuPH20)
4. Participant is willing and able to comply with the requirements of the protocol.
5. Female participant of child-bearing potential agrees to inform the investigator if she becomes pregnant, or plans to become pregnant during the course of the study

Exclusion Criteria

1. Participant has known hypersensitivity to any of the components of the medicinal product
2. Participant has participated in an interventional clinical study involving a medicinal product or device within 30 days prior to enrollment or is scheduled to participate in an interventional clinical study involving a medical product or device during the course of this study
3. Participant is a family member or employee of the investigator
4. Participant is planning to become pregnant, pregnant or breastfeeding at the time of enrollment
Minimum Eligible Age

16 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Baxalta now part of Shire

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Shire Director

Role: STUDY_DIRECTOR

Shire

Locations

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Kern Allergy Medical Clinic

Bakersfield, California, United States

Site Status

University of California Irvine Medical Center

Irvine, California, United States

Site Status

Riviera Allergy Medical Center

Redondo Beach, California, United States

Site Status

Capital Allergy & Respiratory Disease Center

Sacramento, California, United States

Site Status

UCLA School of Medicine

Santa Monica, California, United States

Site Status

Asthma and Allergy Associates, PC

Colorado Springs, Colorado, United States

Site Status

Pikes Peak Allergy and Asthma

Colorado Springs, Colorado, United States

Site Status

IMMUNOe International Research Centers

Thornton, Colorado, United States

Site Status

Georgia Pollens Clinical Research Centers, Inc.

Albany, Georgia, United States

Site Status

Boston Childrens Hospital

Boston, Massachusetts, United States

Site Status

Canton Health Center

Canton, Michigan, United States

Site Status

Washington University

St Louis, Missouri, United States

Site Status

Corning Center for Clinical Research

Corning, New York, United States

Site Status

Northwell Health, Inc. PRIME

Great Neck, New York, United States

Site Status

Winthrop University

Mineola, New York, United States

Site Status

Columbia University Medical Center

New York, New York, United States

Site Status

Montefiore Medical Center

The Bronx, New York, United States

Site Status

Carolinas Healthcare System

Charlotte, North Carolina, United States

Site Status

Allergy Asthma & Immunology Relief of Charlotte

Charlotte, North Carolina, United States

Site Status

Optimed Research, LTD

Columbus, Ohio, United States

Site Status

Allergy, Asthma and Clinical Research Center

Oklahoma City, Oklahoma, United States

Site Status

OK Institute of Allergy & Asthma Clinical Research, LLC

Oklahoma City, Oklahoma, United States

Site Status

Vital Prospects Clinical Research Institute, P.C.

Tulsa, Oklahoma, United States

Site Status

Allergy & Clinical Immunology Associates

Pittsburgh, Pennsylvania, United States

Site Status

National Allergy, Asthma & Urticaria Centers of Charleston, PA

North Charleston, South Carolina, United States

Site Status

Allergy / Immunology Research Center of North Texas

Dallas, Texas, United States

Site Status

Texas Children's Hospital

Houston, Texas, United States

Site Status

McKinney Allergy and Asthma Center

McKinney, Texas, United States

Site Status

Greater Austin Allergy, Asthma, & Immunology

Round Rock, Texas, United States

Site Status

University of Utah

Salt Lake City, Utah, United States

Site Status

Countries

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United States

Related Links

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Other Identifiers

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EUPAS21523

Identifier Type: REGISTRY

Identifier Source: secondary_id

161406

Identifier Type: -

Identifier Source: org_study_id

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