Mechanisms of Acupuncture Analgesia on Experimental Dental Pain - A Psychophysical Study (Phase1)
NCT ID: NCT02589418
Last Updated: 2016-03-15
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
COMPLETED
NA
35 participants
INTERVENTIONAL
2015-10-31
2016-03-31
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Complementary Medicine Approaches to TMD Pain Management
NCT00010621
Clinical Efficacy of Acupuncture in the Treatment of Temporomandibular Disorders (TMD)
NCT04210921
Treatment Efficiency of Acupuncture in Non Chronified Pain Patients With TMDs
NCT02637544
The Clinical Benefits of the Combination Use of Acupuncture and Antihistamine on Trigeminal Neuralgia
NCT04384224
Cytokine and Growth Factor Changes and Correlation With Clinical Outcomes Following Acupuncture for TMD
NCT02324712
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
In this preceding study, the characterization of manual acupuncture effects on the experimental dental pain model will be tested under laboratory conditions and without restrictions of an fMRI-measurement in order to provide a sound foundation for the following fMRI-experiment. Pain modulating effects of the manual acupuncture intervention (4 points: needle manipulation of bilateral large-intestine 4 (LI4), stomach 6 and 7 (ST6, ST7) ipsilateral to the stimulated tooth) will be compared to sham-acupuncture (insertion and manipulation of 4 non-acupuncture points) and a control intervention (no acupuncture) which will each be performed at 3 different days in a randomized order. Intervention effects on experimental dental pain will be assessed by testing of 36 healthy volunteers by means of subjective pain intensity ratings and pain-specific ANS reactions such as electrodermal activity and heart rate/respiratory changes. Besides laying the groundwork for the following fMRI experiment, this study could provide valuable basic insights into the dynamics of the tested manual acupuncture effects and further provide important knowledge for the planning of future clinical studies encompassing dental conditions and development of acupuncture treatments.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
NA
SINGLE_GROUP
TREATMENT
SINGLE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Healthy subjects
All subjects participate at 3 experimental conditions (Acupuncture, Sham-Acupuncture and No Acupuncture) at 3 different days in a randomized order.
Acupuncture
Needle insertion and manipulation at 4 acupuncture points (bilateral LI4, right ST6 and ST7).
Sham-Acupuncture
Needle insertion and manipulation at 4 non-acupoints
No Acupuncture
Control intervention: No needle insertion and manipulation
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
Acupuncture
Needle insertion and manipulation at 4 acupuncture points (bilateral LI4, right ST6 and ST7).
Sham-Acupuncture
Needle insertion and manipulation at 4 non-acupoints
No Acupuncture
Control intervention: No needle insertion and manipulation
Other Intervention Names
Discover alternative or legacy names that may be used to describe the listed interventions across different sources.
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* Written informed consent
* Fluent in German language
* Sufficient dental sensitivity for the tooth stimulation
* No acupuncture treatment in the previous 12 months
* No medical knowledge about acupuncure
Exclusion Criteria
* Complaints of diseases of the oral cavity
* Pre-existing neurological and(or psychiatric conditions
* History of severe dental pain
* Regular intake of pain medication
* History of brain injuries
* Alcohol and drug abuse
* Chronic diseases that require a permanent intake of drugs
18 Years
40 Years
MALE
Yes
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
OTHER
Charite University, Berlin, Germany
OTHER
University of Zurich
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Claudia Witt
Prof. Dr. med. Claudia M. Witt, MBA
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Claudia M Witt, MD
Role: PRINCIPAL_INVESTIGATOR
University of Zurich
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
Clinic of Masticatory Disorders, Removable Prosthodontics, Geriatric and Special Care Dentistry Center of Dental Medicine University of Zurich
Zurich, Canton of Zurich, Switzerland
Institute for Complementary and Integrative Medicine, University Hospital Zurich
Zurich, Canton of Zurich, Switzerland
Countries
Review the countries where the study has at least one active or historical site.
References
Explore related publications, articles, or registry entries linked to this study.
Bieling PJ, Antony MM, Swinson RP. The State-Trait Anxiety Inventory, Trait version: structure and content re-examined. Behav Res Ther. 1998 Jul-Aug;36(7-8):777-88. doi: 10.1016/s0005-7967(98)00023-0.
de Matos NMP, Pach D, Xing JJ, Barth J, Beyer LE, Shi X, Kern A, Lukic N, Ettlin DA, Brugger M, Witt CM. Evaluating the Effects of Acupuncture Using a Dental Pain Model in Healthy Subjects - A Randomized, Cross-Over Trial. J Pain. 2020 Mar-Apr;21(3-4):440-454. doi: 10.1016/j.jpain.2019.08.013. Epub 2019 Sep 12.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
MAC-DENT-Psy
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.