Fibrosis, Valvular and Ventricular Function in Patients With TGA

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

37 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-10-31

Study Completion Date

2027-06-30

Brief Summary

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The aim of this project is to better evaluate the systemic right ventricular (RV) function in patients with transposition of the great arteries (TGA).

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Detailed Description

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Patients with TGA frequently develop supraventricular and ventricular arrhythmia, conduction problems, systemic atrioventricular valve (SAVV) regurgitation, and congestive heart failure (CHF), all at young age. However, there is variation in time of onset of these adverse events. We want to evaluate ventricular and valvular function at rest, markers of RV fibrosis and cardiac reserve.

Conditions

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Transposition of Great Vessels

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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transposition of the great arteries

Patients with a TGA

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Patients with a TGA
* Informed consent to participate. If the patient is under the age of 18, the assent of the patient and the permission of the parents to participate

Exclusion Criteria

* Previous double-switch intervention
* Any medical contra-indication for cardiovascular magnetic resonance (CMR) imaging (e.g. pacemaker)
* The presence of exercise-induced arrhythmia, symptomatic myocardial ischemia, a resting systolic blood pressure \> 200 mm Hg and/or diastolic blood pressure \> 110 mm Hg, New York Heart Association (NYHA) class III or IV, or non-cardiac co-morbidity that could aggravate by exercise
* Additional exclusion criterion for delayed gadolinium enhancement CMR: any medical contra-indication for intravenous gadolinium

Minimum Eligible Age

16 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No