Study to Understand Usage and Effect of Saxagliptin as First Add-On After Metformin in Indian Type 2 Diabetes Mellitus Patients

NCT ID: NCT02588859

Last Updated: 2017-12-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

1200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-10-30

Study Completion Date

2016-12-26

Brief Summary

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This is a multicentre, non-interventional, prospective, observational study which would be conducted in India to understand the usage and effect of saxagliptin as first add-on therapy after metformin. The study will enroll Type 2 Diabetes Mellitus (T2DM) patients who were inadequately controlled with metformin alone and have been recently prescribed saxagliptin as an add-on to metformin.

Detailed Description

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This is a multicentre, non-interventional, prospective, observational study which would be conducted in India to understand the usage and effect of saxagliptin as first add-on therapy after metformin. The study will enroll Type 2 Diabetes Mellitus (T2DM) patients who were inadequately controlled with metformin alone and have been recently (i.e. within past 15 days) prescribed saxagliptin as an add-on to metformin.

The Investigator/designee would get signed informed consent from potential subjects of the study. The patients who meet all inclusion and none of the exclusion criteria will be enrolled in the study. These patients will then be assigned a patient identification number for the study. The Investigator/designee will collect the information as per the study schedule. This will be considered as Visit 1 of the patients. The patients will be managed as per the routine clinical practice of the physician for their condition and this study will neither interfere/advise the Investigators/designee for any drug/medication to be prescribed to the patients nor prescribe any intervention to them.The enrolled patients would then be asked to visit their respective study sites after 3 months ( +7 days) for the Visit-2 of study.

Around 50 study centers throughout India will be selected with a goal of enrolling up to 1500 patients (approximately 30 subjects each per site). The study will be initiated after obtaining written approval of Independent/Institutional Ethics Committee and written Informed consent of the patient.

Conditions

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Type 2 Diabetes

Keywords

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T2DM, Diabetes

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

1. Patients willing to provide informed consent.
2. Female or male patients aged 18 years or above.
3. Patients with known case of Type 2 diabetes mellitus.
4. Patients with inadequate glycaemic control taking metformin monotherapy (minimum dose of 500 mg OD) for at least 3 months.
5. Patients who have recently (last 15 days) been prescribed saxagliptin in addition to metformin.

Exclusion Criteria

1. Patients with Type 1 diabetes mellitus.
2. Patients taking glucose lowering drugs apart from metformin or saxagliptin.
3. Any medical condition of the patient which in the opinion of Investigator would interfere with safe completion of the study.
4. Pregnant or lactating women.
5. Women of childbearing potential not ready to use an effective barrier contraceptive method during the study.
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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AstraZeneca

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Dr Sanjay Kalra, MD, DM (Endocrinology)

Role: STUDY_CHAIR

Bharti Research Institute of Diabetes & Endocrinology, Karnal

Dr Bhavesh P Kotak, FRCS, MS, D Orth

Role: STUDY_DIRECTOR

AstraZeneca Pharma India Ltd

Locations

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Research Site

Nellure, Andhra Pradesh, India

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Visakhapatnam, Andhra Pradesh, India

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Guwahati, Assam, India

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Ahmedabad, Gujarat, India

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Rajkot, Gujarat, India

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Vadodara, Gujarat, India

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Karnāl, Haryana, India

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Yamuna Nagar, Haryana, India

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Bangalore, Karnataka, India

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Trivandrum, Kerala, India

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Kochi, Kochi, India

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Bhopal, Madhya Pradesh, India

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Indore, Madhya Pradesh, India

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Mumbai, Maharashtra, India

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Pune, Maharashtra, India

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New Delhi, National Capital Territory of Delhi, India

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Amritsar, Punjab, India

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Chandigarh, Punjab, India

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Ludhiana, Punjab, India

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Jaipur, Rajasthan, India

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Udaipur, Rajasthan, India

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Chennai, Tamil Nadu, India

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Madurai, Tamiladu, India

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Hyderabad, Telangana, India

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Hyderebad, Telangana, India

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Allahābād, Uttar Pradesh, India

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Kanpur, Uttar Pradesh, India

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Lucknow, Uttar Pradesh, India

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Noida, Uttar Pradesh, India

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Kolkata, West Bengal, India

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New Delhi, , India

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Countries

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India

References

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Kalra S, Bajaj S, Unnikrishnan AG, Baruah MP, Sahay R, Hardik V, Kumar A. Therapeutic Experience of Saxagliptin as First Add-on after Metformin in Indian Type 2 Diabetes Patients: A Non-interventional, Prospective, Observational Study (ONTARGET-INDIA). Indian J Endocrinol Metab. 2019 May-Jun;23(3):312-317. doi: 10.4103/ijem.IJEM_56_19.

Reference Type DERIVED
PMID: 31641633 (View on PubMed)

Related Links

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Other Identifiers

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D1680R00019

Identifier Type: -

Identifier Source: org_study_id