Sleep Timing and Insulin Resistance in Adolescents With Obesity

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

25 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-10-31

Study Completion Date

2017-05-31

Brief Summary

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This study examines the relationship between sleep timing and insulin resistance in adolescents with obesity. The investigators also aim to develop a physiologically-based mathematical model of adolescent sleep/wake and circadian interactions.

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Detailed Description

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Conditions

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Obesity

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

CROSS_SECTIONAL

Eligibility Criteria

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Inclusion Criteria

* High school students between the ages of 15-19
* BMI \> 90th percentile
* Tanner stage 2 or greater

Exclusion Criteria

* Any medications that affect insulin resistance or sleep (e.g., metformin, hormonal contraception, stimulants, atypical antipsychotics)
* Regular use of melatonin or sleep aids
* A prior diagnosis of obstructive sleep apnea, diabetes (HbA1c \> 6.5), liver disease other than non-alcoholic fatty liver disease, pregnancy or breastfeeding
* IQ \< 70 or severe mental illness that may impact sleep (e.g., schizophrenia, psychotic episodes)
* Not enrolled in a traditional high school academic program (e.g., home school students)
* Night shift employment
* Travel across more than 2 time zones in the month prior to the study

Minimum Eligible Age

15 Years

Maximum Eligible Age

19 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes