An Observational Study to Evaluate Safety and Efficacy of Remsima™ in Patients With RA

NCT ID: NCT02557295

Last Updated: 2024-11-26

Study Results

Results available

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Basic Information

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Recruitment Status

TERMINATED

Total Enrollment

248 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-12-17

Study Completion Date

2020-03-02

Brief Summary

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An Observational, Prospective Cohort Study to Evaluate Safety and Efficacy of RemsimaTM in Patients with Rheumatoid Arthritis.

Detailed Description

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This is a longitudinal, observational, prospective cohort study to assess the safety and efficacy of RemsimaTM in patients with RA in comparison with patients receiving non-biologic treatmentsor other anti-TNF drugs. For the RemsimaTM cohort data will be collected for patients who commence treatment with RemsimaTM in accordance with the product label at the time of enrolment (3 mg/kg of RemsimaTM by IV infusion at weeks 0, 2, 6 (±3 days) and every 8 weeks (±14 days) thereafter). For patients who have been treated with Remicade® prior to enrolment, their dosing schedule will be continued appropriately. This observational study allows drug switching between anti-TNF drugs. If switched to RemsimaTM, data will be collected until the end of study for each patient. If switched to other anti-TNF drugs (infliximab (Remicade®), etanercept, adalimumab and etc.), data will be collected until 1 year from the day of switch or until the end of study for each patient, whichever reaches earlier.

Conditions

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Rheumatoid Arthritis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Remsima™

Patients who have received only Remsima or switched from non-biologic treatment to Remsima were included in this analysis group.

No interventions assigned to this group

Switch to Remsima I

Patients who switched from Remicade to Remsima were included in this analysis group.

No interventions assigned to this group

Switch to Remsima II

Patients who switched to Remsima from biologic treatment other than Remicade were included in this analysis group.

No interventions assigned to this group

Remicade

Patients who have received only Remicade or switched from non-biologic treatment to Remsima were included in this analysis group.

No interventions assigned to this group

Switch to Remicade I

Patients who switched from Remsima to Remicade were included in this analysis group.

No interventions assigned to this group

Switch to Remicade II

Patients who switched to Remicade from biologic treatment other than Remsima will be included in this analysis group.

No interventions assigned to this group

Other Anti-TNF

Following patients were included in other anti-TNF group.

* Patients who have received only anti-TNF other than Remsima or Remicade
* Patients who switched from non-biologic treatment to anti-TNF other than Remsima or Remicade
* Patients who switched from biologic treatment other than anti-TNF before study enrolment to anti-TNF other than Remsima or Remicade

No interventions assigned to this group

Switch to Other Anti-TNF

Patients who switched from Remsima or Remicade to other anti-TNF other than Remicade will be included in this analysis group

No interventions assigned to this group

Biologic Naïve

Patients who received only non-biologic treatment will be included in this analysis group

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

1. Adult patients
2. Patients with active RA diagnosed according to the revised 1987 ACR or 2010 ACR/EULAR classification criteria

Exclusion Criteria

1. Patients with a history of hypersensitivity to murine, chimeric, human, or humanized proteins.
2. Patients with a current or past history of chronic infection
3. Patients with moderate or severe heart failure (NYHA class III/IV).
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Celltrion

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Klara Sirova

Role: PRINCIPAL_INVESTIGATOR

Revmatologie MUDr. Klara Sirova s.r.o. Chelčického 616/12 , 702 00, Czech Republic

References

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Cheon JH, Nah S, Kang HW, Lim YJ, Lee SH, Lee SJ, Kim SH, Jung NH, Park JE, Lee YJ, Jeon DB, Lee YM, Kim JM, Park SH. Infliximab Biosimilar CT-P13 Observational Studies for Rheumatoid Arthritis, Inflammatory Bowel Diseases, and Ankylosing Spondylitis: Pooled Analysis of Long-Term Safety and Effectiveness. Adv Ther. 2021 Aug;38(8):4366-4387. doi: 10.1007/s12325-021-01834-3. Epub 2021 Jul 12.

Reference Type DERIVED
PMID: 34250583 (View on PubMed)

Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

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CT-P13 4.2

Identifier Type: -

Identifier Source: org_study_id

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