Trial Outcomes & Findings for Psoriasis Microbiome and Phototherapy (NCT NCT02552316)

Last Updated: 2020-12-02

Results Overview

Variation in the microbial diversity of skin affected and unaffected by psoriasis was characterized at baseline. The Alpha Diversity Index is a quantitative measure that reflects the diversity of bacterial species in a sample. The greater the index value, the more diverse the skin microbiota. The diversity of the microbiota present in the given sample was measured using the Shannon Diversity Index, whereby each "arm title" is describing the difference in the measure of diversity between the comparison groups.

Recruitment status

COMPLETED

Study phase

Target enrollment

34 participants

Primary outcome timeframe

Baseline

Results posted on

2020-12-02

Participant Flow

Participant milestones

Participant milestones
Measure	NB-UVB Phototherapy Narrow band-UVB (NB-UVB) phototherapy is a therapy which uses ultraviolet B (UVB) light directed at the skin. This type of light therapy is given through the use of phototherapy booths which contain fluorescent tubes that emit UVB light. Booths used for phototherapy look similar to commercial tanning booths. NB-UVB phototherapy affects psoriasis by causing changes to the cells of the skin and producing a local effect by reducing the number of certain types of skin cells which have an impact on psoriasis formation. In the study, NB-UVB phototherapy administered 3 times per week for 8 weeks.
Overall Study STARTED	34
Overall Study COMPLETED	32
Overall Study NOT COMPLETED	2

Reasons for withdrawal

Reasons for withdrawal
Measure	NB-UVB Phototherapy Narrow band-UVB (NB-UVB) phototherapy is a therapy which uses ultraviolet B (UVB) light directed at the skin. This type of light therapy is given through the use of phototherapy booths which contain fluorescent tubes that emit UVB light. Booths used for phototherapy look similar to commercial tanning booths. NB-UVB phototherapy affects psoriasis by causing changes to the cells of the skin and producing a local effect by reducing the number of certain types of skin cells which have an impact on psoriasis formation. In the study, NB-UVB phototherapy administered 3 times per week for 8 weeks.
Overall Study Withdrawal by Subject	1
Overall Study Withdrawal due to non-compliance	1

Baseline Characteristics

Psoriasis Microbiome and Phototherapy

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure	NB-UVB Phototherapy n=34 Participants NB-UVB phototherapy is a therapy which uses ultraviolet B (UVB) light directed at the skin. This type of light therapy is given through the use of phototherapy booths which contain fluorescent tubes that emit UVB light. Booths used for phototherapy look similar to commercial tanning booths. NB-UVB phototherapy affects psoriasis by causing changes to the cells of the skin and producing a local effect by reducing the number of certain types of skin cells which have an impact on psoriasis formation. NB-UVB Phototherapy
Age, Continuous	45.5 years n=5 Participants
Sex: Female, Male Female	11 Participants n=5 Participants
Sex: Female, Male Male	23 Participants n=5 Participants
Ethnicity (NIH/OMB) Hispanic or Latino	3 Participants n=5 Participants
Ethnicity (NIH/OMB) Not Hispanic or Latino	31 Participants n=5 Participants
Ethnicity (NIH/OMB) Unknown or Not Reported	0 Participants n=5 Participants
Race (NIH/OMB) American Indian or Alaska Native	1 Participants n=5 Participants
Race (NIH/OMB) Asian	3 Participants n=5 Participants
Race (NIH/OMB) Native Hawaiian or Other Pacific Islander	0 Participants n=5 Participants
Race (NIH/OMB) Black or African American	6 Participants n=5 Participants
Race (NIH/OMB) White	22 Participants n=5 Participants
Race (NIH/OMB) More than one race	0 Participants n=5 Participants
Race (NIH/OMB) Unknown or Not Reported	2 Participants n=5 Participants
Body Mass Index	29.60 Kg/m^2 n=5 Participants
Fitzpatrick skin type Type I	1 Participants n=5 Participants
Fitzpatrick skin type Type II	18 Participants n=5 Participants
Fitzpatrick skin type Type III	6 Participants n=5 Participants
Fitzpatrick skin type Type IV	4 Participants n=5 Participants
Fitzpatrick skin type Type V	5 Participants n=5 Participants
Age of psoriasis onset < 20 years	16 Participants n=5 Participants
Age of psoriasis onset 20 - 39 years	10 Participants n=5 Participants
Age of psoriasis onset ≥40 years	8 Participants n=5 Participants
Duration of psoriasis (year)	11.5 years n=5 Participants
Psoriasis Area and Severity Index (PASI) score	9.55 units on a scale n=5 Participants
Physician Global Assessment (PGA) Overall	3 units on a scale n=5 Participants
Physician Global Assessment (PGA) Lesion	3 units on a scale n=5 Participants
Body Surface Area (BSA)	7.55 percentage (%) n=5 Participants
Psoriatic arthritis diagnosis No	33 Participants n=5 Participants
Psoriatic arthritis diagnosis Yes	1 Participants n=5 Participants
Plaque location Arm	8 Participants n=5 Participants
Plaque location Leg	26 Participants n=5 Participants

PRIMARY outcome

Timeframe: Baseline

Outcome measures

Outcome measures
Measure	Group 1a- Plaque Center vs Plaque Edge n=15 Participants The diversity of microbiota present in a given sample measured using the Shannon Diversity Index at baseline prior to initiation of phototherapy. Difference in the measure of Shannon diversity index between plaque center vs plaque edge.	Group 1b- Plaque Center vs Ipsilateral Perilesional Unaffected n=24 Participants The diversity of microbiota present in a given sample measured using the Shannon Diversity Index at baseline prior to initiation of phototherapy. Difference in the measure of Shannon diversity index between plaque center vs ipsilateral perilesional unaffected skin	Group 1c- Plaque Center vs Ipsilateral Distant Unaffected Skin n=26 Participants The diversity of microbiota present in a given sample measured using the Shannon Diversity Index at baseline prior to initiation of phototherapy. Difference in the measure of Shannon diversity index between plaque center vs ipsilateral distant unaffected skin.	Group 1d- Ipsilateral Unaffected Skin: Perilesional vs Distant n=29 Participants The diversity of microbiota present in a given sample measured using the Shannon Diversity Index at baseline prior to initiation of phototherapy. Difference in the measure of Shannon diversity index between perilesional ipsilateral unaffected skin vs distant ipsilateral unaffected skin.	Group 1e- Plaque Center vs Contralateral Unaffected Skin n=10 Participants The diversity of microbiota present in a given sample measured using the Shannon Diversity Index at baseline prior to initiation of phototherapy. Difference in the measure of Shannon diversity index between plaque center vs contralateral unaffected skin.	Group 6 The diversity of microbiota present in a given sample measured using the Jaccard's Diversity Index at baseline prior to initiation of phototherapy. Comparison of differences in mean between Ipsilateral distant unaffected skin vs plaque center and contralateral unaffected skin vs plaque center at baseline.
Cutaneous Microbiota Shannon's Alpha Diversity at Baseline	-0.05 Shannon's index Standard Error 0.06	0.06 Shannon's index Standard Error 0.10	-0.06 Shannon's index Standard Error 0.09	0.12 Shannon's index Standard Error 0.08	0.26 Shannon's index Standard Error 0.12	—

PRIMARY outcome

Timeframe: Week 8

Variation in the microbial diversity of skin affected and unaffected by psoriasis was characterized at baseline. Changes in microbial diversity was assessed between baseline and week 8. The Alpha Diversity Index is a quantitative measure that reflects the diversity of bacterial species in a sample. The greater the index value, the more diverse the skin microbiota. The diversity of the microbiota present in the given sample was measured using the Shannon Diversity Index, whereby each "arm title" is describing the difference in the measure of diversity between the comparison groups.

Outcome measures

Outcome measures
Measure	Group 1a- Plaque Center vs Plaque Edge n=26 Participants The diversity of microbiota present in a given sample measured using the Shannon Diversity Index at baseline prior to initiation of phototherapy. Difference in the measure of Shannon diversity index between plaque center vs plaque edge.	Group 1b- Plaque Center vs Ipsilateral Perilesional Unaffected n=25 Participants The diversity of microbiota present in a given sample measured using the Shannon Diversity Index at baseline prior to initiation of phototherapy. Difference in the measure of Shannon diversity index between plaque center vs ipsilateral perilesional unaffected skin	Group 1c- Plaque Center vs Ipsilateral Distant Unaffected Skin n=12 Participants The diversity of microbiota present in a given sample measured using the Shannon Diversity Index at baseline prior to initiation of phototherapy. Difference in the measure of Shannon diversity index between plaque center vs ipsilateral distant unaffected skin.	Group 1d- Ipsilateral Unaffected Skin: Perilesional vs Distant n=30 Participants The diversity of microbiota present in a given sample measured using the Shannon Diversity Index at baseline prior to initiation of phototherapy. Difference in the measure of Shannon diversity index between perilesional ipsilateral unaffected skin vs distant ipsilateral unaffected skin.	Group 1e- Plaque Center vs Contralateral Unaffected Skin The diversity of microbiota present in a given sample measured using the Shannon Diversity Index at baseline prior to initiation of phototherapy. Difference in the measure of Shannon diversity index between plaque center vs contralateral unaffected skin.	Group 6 The diversity of microbiota present in a given sample measured using the Jaccard's Diversity Index at baseline prior to initiation of phototherapy. Comparison of differences in mean between Ipsilateral distant unaffected skin vs plaque center and contralateral unaffected skin vs plaque center at baseline.
Change in Cutaneous Microbiota Shannon's Alpha Diversity at Baseline vs Week 8	-0.08 Shannon's index Standard Error 0.12	-0.12 Shannon's index Standard Error 0.11	0.03 Shannon's index Standard Error 0.16	-0.07 Shannon's index Standard Error 0.13	—	—

PRIMARY outcome

Timeframe: Week 9

Variation in the microbial diversity of skin affected and unaffected by psoriasis was characterized at baseline. Changes in microbial diversity was assessed between baseline and week 9. The Alpha Diversity Index is a quantitative measure that reflects the diversity of bacterial species in a sample. The greater the index value, the more diverse the skin microbiota. The diversity of the microbiota present in the given sample was measured using the Shannon Diversity Index, whereby each "arm title" is describing the difference in the measure of diversity between the comparison groups.

Outcome measures

Outcome measures
Measure	Group 1a- Plaque Center vs Plaque Edge n=26 Participants The diversity of microbiota present in a given sample measured using the Shannon Diversity Index at baseline prior to initiation of phototherapy. Difference in the measure of Shannon diversity index between plaque center vs plaque edge.	Group 1b- Plaque Center vs Ipsilateral Perilesional Unaffected n=25 Participants The diversity of microbiota present in a given sample measured using the Shannon Diversity Index at baseline prior to initiation of phototherapy. Difference in the measure of Shannon diversity index between plaque center vs ipsilateral perilesional unaffected skin	Group 1c- Plaque Center vs Ipsilateral Distant Unaffected Skin n=11 Participants The diversity of microbiota present in a given sample measured using the Shannon Diversity Index at baseline prior to initiation of phototherapy. Difference in the measure of Shannon diversity index between plaque center vs ipsilateral distant unaffected skin.	Group 1d- Ipsilateral Unaffected Skin: Perilesional vs Distant n=31 Participants The diversity of microbiota present in a given sample measured using the Shannon Diversity Index at baseline prior to initiation of phototherapy. Difference in the measure of Shannon diversity index between perilesional ipsilateral unaffected skin vs distant ipsilateral unaffected skin.	Group 1e- Plaque Center vs Contralateral Unaffected Skin The diversity of microbiota present in a given sample measured using the Shannon Diversity Index at baseline prior to initiation of phototherapy. Difference in the measure of Shannon diversity index between plaque center vs contralateral unaffected skin.	Group 6 The diversity of microbiota present in a given sample measured using the Jaccard's Diversity Index at baseline prior to initiation of phototherapy. Comparison of differences in mean between Ipsilateral distant unaffected skin vs plaque center and contralateral unaffected skin vs plaque center at baseline.
Change in Cutaneous Microbiota Shannon's Alpha Diversity at Baseline vs Week 9.	-0.03 Shannon's index Standard Error 0.11	-0.13 Shannon's index Standard Error 0.16	-0.01 Shannon's index Standard Error 0.16	0.19 Shannon's index Standard Error 0.11	—	—

PRIMARY outcome

Timeframe: Baseline

Variation in the microbial diversity of skin affected and unaffected by psoriasis was characterized at baseline. The Beta Diversity Index is a quantitative measure that reflects the diversity of bacterial species between two different regions. The greater the index, the more diverse the microbiota between the two regions.

Outcome measures

Outcome measures
Measure	Group 1a- Plaque Center vs Plaque Edge n=24 Participants The diversity of microbiota present in a given sample measured using the Shannon Diversity Index at baseline prior to initiation of phototherapy. Difference in the measure of Shannon diversity index between plaque center vs plaque edge.	Group 1b- Plaque Center vs Ipsilateral Perilesional Unaffected n=27 Participants The diversity of microbiota present in a given sample measured using the Shannon Diversity Index at baseline prior to initiation of phototherapy. Difference in the measure of Shannon diversity index between plaque center vs ipsilateral perilesional unaffected skin	Group 1c- Plaque Center vs Ipsilateral Distant Unaffected Skin n=20 Participants The diversity of microbiota present in a given sample measured using the Shannon Diversity Index at baseline prior to initiation of phototherapy. Difference in the measure of Shannon diversity index between plaque center vs ipsilateral distant unaffected skin.	Group 1d- Ipsilateral Unaffected Skin: Perilesional vs Distant n=27 Participants The diversity of microbiota present in a given sample measured using the Shannon Diversity Index at baseline prior to initiation of phototherapy. Difference in the measure of Shannon diversity index between perilesional ipsilateral unaffected skin vs distant ipsilateral unaffected skin.	Group 1e- Plaque Center vs Contralateral Unaffected Skin n=26 Participants The diversity of microbiota present in a given sample measured using the Shannon Diversity Index at baseline prior to initiation of phototherapy. Difference in the measure of Shannon diversity index between plaque center vs contralateral unaffected skin.	Group 6 n=27 Participants The diversity of microbiota present in a given sample measured using the Jaccard's Diversity Index at baseline prior to initiation of phototherapy. Comparison of differences in mean between Ipsilateral distant unaffected skin vs plaque center and contralateral unaffected skin vs plaque center at baseline.
Cutaneous Microbiota Jaccard's Beta Diversity at Baseline	0.003 Jaccard index Standard Error 0.015	0.012 Jaccard index Standard Error 0.014	0.021 Jaccard index Standard Error 0.015	0.009 Jaccard index Standard Error 0.010	0.018 Jaccard index Standard Error 0.011	0.009 Jaccard index Standard Error 0.010

PRIMARY outcome

Timeframe: Week 8

Outcome measures

Outcome measures
Measure	Group 1a- Plaque Center vs Plaque Edge n=15 Participants The diversity of microbiota present in a given sample measured using the Shannon Diversity Index at baseline prior to initiation of phototherapy. Difference in the measure of Shannon diversity index between plaque center vs plaque edge.	Group 1b- Plaque Center vs Ipsilateral Perilesional Unaffected n=29 Participants The diversity of microbiota present in a given sample measured using the Shannon Diversity Index at baseline prior to initiation of phototherapy. Difference in the measure of Shannon diversity index between plaque center vs ipsilateral perilesional unaffected skin	Group 1c- Plaque Center vs Ipsilateral Distant Unaffected Skin n=29 Participants The diversity of microbiota present in a given sample measured using the Shannon Diversity Index at baseline prior to initiation of phototherapy. Difference in the measure of Shannon diversity index between plaque center vs ipsilateral distant unaffected skin.	Group 1d- Ipsilateral Unaffected Skin: Perilesional vs Distant n=15 Participants The diversity of microbiota present in a given sample measured using the Shannon Diversity Index at baseline prior to initiation of phototherapy. Difference in the measure of Shannon diversity index between perilesional ipsilateral unaffected skin vs distant ipsilateral unaffected skin.	Group 1e- Plaque Center vs Contralateral Unaffected Skin n=32 Participants The diversity of microbiota present in a given sample measured using the Shannon Diversity Index at baseline prior to initiation of phototherapy. Difference in the measure of Shannon diversity index between plaque center vs contralateral unaffected skin.	Group 6 The diversity of microbiota present in a given sample measured using the Jaccard's Diversity Index at baseline prior to initiation of phototherapy. Comparison of differences in mean between Ipsilateral distant unaffected skin vs plaque center and contralateral unaffected skin vs plaque center at baseline.
Change in Cutaneous Microbiota Jaccard's Beta Diversity at Baseline vs Week 8	-0.021 Jaccard's index Standard Error 0.020	-0.002 Jaccard's index Standard Error 0.016	0.008 Jaccard's index Standard Error 0.009	0.013 Jaccard's index Standard Error 0.011	0.008 Jaccard's index Standard Error 0.010	—

PRIMARY outcome

Timeframe: Week 9

Outcome measures

Outcome measures
Measure	Group 1a- Plaque Center vs Plaque Edge n=15 Participants The diversity of microbiota present in a given sample measured using the Shannon Diversity Index at baseline prior to initiation of phototherapy. Difference in the measure of Shannon diversity index between plaque center vs plaque edge.	Group 1b- Plaque Center vs Ipsilateral Perilesional Unaffected n=28 Participants The diversity of microbiota present in a given sample measured using the Shannon Diversity Index at baseline prior to initiation of phototherapy. Difference in the measure of Shannon diversity index between plaque center vs ipsilateral perilesional unaffected skin	Group 1c- Plaque Center vs Ipsilateral Distant Unaffected Skin n=29 Participants The diversity of microbiota present in a given sample measured using the Shannon Diversity Index at baseline prior to initiation of phototherapy. Difference in the measure of Shannon diversity index between plaque center vs ipsilateral distant unaffected skin.	Group 1d- Ipsilateral Unaffected Skin: Perilesional vs Distant n=15 Participants The diversity of microbiota present in a given sample measured using the Shannon Diversity Index at baseline prior to initiation of phototherapy. Difference in the measure of Shannon diversity index between perilesional ipsilateral unaffected skin vs distant ipsilateral unaffected skin.	Group 1e- Plaque Center vs Contralateral Unaffected Skin n=32 Participants The diversity of microbiota present in a given sample measured using the Shannon Diversity Index at baseline prior to initiation of phototherapy. Difference in the measure of Shannon diversity index between plaque center vs contralateral unaffected skin.	Group 6 The diversity of microbiota present in a given sample measured using the Jaccard's Diversity Index at baseline prior to initiation of phototherapy. Comparison of differences in mean between Ipsilateral distant unaffected skin vs plaque center and contralateral unaffected skin vs plaque center at baseline.
Change in Cutaneous Microbiota Jaccard's Beta Diversity at Baseline vs Week 9	-0.016 Jaccard's index Standard Error 0.019	-0.001 Jaccard's index Standard Error 0.010	-0.007 Jaccard's index Standard Error 0.009	-0.004 Jaccard's index Standard Error 0.011	0.0002 Jaccard's index Standard Error 0.011	—

PRIMARY outcome

Timeframe: Baseline

Bacterial count per sample at baseline prior to initiation of phototherapy.

Outcome measures

Outcome measures
Measure	Group 1a- Plaque Center vs Plaque Edge n=34 Participants The diversity of microbiota present in a given sample measured using the Shannon Diversity Index at baseline prior to initiation of phototherapy. Difference in the measure of Shannon diversity index between plaque center vs plaque edge.	Group 1b- Plaque Center vs Ipsilateral Perilesional Unaffected n=34 Participants The diversity of microbiota present in a given sample measured using the Shannon Diversity Index at baseline prior to initiation of phototherapy. Difference in the measure of Shannon diversity index between plaque center vs ipsilateral perilesional unaffected skin	Group 1c- Plaque Center vs Ipsilateral Distant Unaffected Skin n=34 Participants The diversity of microbiota present in a given sample measured using the Shannon Diversity Index at baseline prior to initiation of phototherapy. Difference in the measure of Shannon diversity index between plaque center vs ipsilateral distant unaffected skin.	Group 1d- Ipsilateral Unaffected Skin: Perilesional vs Distant n=34 Participants The diversity of microbiota present in a given sample measured using the Shannon Diversity Index at baseline prior to initiation of phototherapy. Difference in the measure of Shannon diversity index between perilesional ipsilateral unaffected skin vs distant ipsilateral unaffected skin.	Group 1e- Plaque Center vs Contralateral Unaffected Skin The diversity of microbiota present in a given sample measured using the Shannon Diversity Index at baseline prior to initiation of phototherapy. Difference in the measure of Shannon diversity index between plaque center vs contralateral unaffected skin.	Group 6 The diversity of microbiota present in a given sample measured using the Jaccard's Diversity Index at baseline prior to initiation of phototherapy. Comparison of differences in mean between Ipsilateral distant unaffected skin vs plaque center and contralateral unaffected skin vs plaque center at baseline.
Cutaneous Bacterial Load at Baseline	0.21 Log10 [bacterial count/sample] Standard Error 0.24	0.60 Log10 [bacterial count/sample] Standard Error 0.18	0.71 Log10 [bacterial count/sample] Standard Error 0.17	0.57 Log10 [bacterial count/sample] Standard Error 0.21	—	—

PRIMARY outcome

Timeframe: Week 8

Bacterial count per sample at baseline prior to initiation of phototherapy vs at week 8 after initiation of phototherapy.

Outcome measures

Outcome measures
Measure	Group 1a- Plaque Center vs Plaque Edge n=34 Participants The diversity of microbiota present in a given sample measured using the Shannon Diversity Index at baseline prior to initiation of phototherapy. Difference in the measure of Shannon diversity index between plaque center vs plaque edge.	Group 1b- Plaque Center vs Ipsilateral Perilesional Unaffected n=18 Participants The diversity of microbiota present in a given sample measured using the Shannon Diversity Index at baseline prior to initiation of phototherapy. Difference in the measure of Shannon diversity index between plaque center vs ipsilateral perilesional unaffected skin	Group 1c- Plaque Center vs Ipsilateral Distant Unaffected Skin n=31 Participants The diversity of microbiota present in a given sample measured using the Shannon Diversity Index at baseline prior to initiation of phototherapy. Difference in the measure of Shannon diversity index between plaque center vs ipsilateral distant unaffected skin.	Group 1d- Ipsilateral Unaffected Skin: Perilesional vs Distant n=32 Participants The diversity of microbiota present in a given sample measured using the Shannon Diversity Index at baseline prior to initiation of phototherapy. Difference in the measure of Shannon diversity index between perilesional ipsilateral unaffected skin vs distant ipsilateral unaffected skin.	Group 1e- Plaque Center vs Contralateral Unaffected Skin n=16 Participants The diversity of microbiota present in a given sample measured using the Shannon Diversity Index at baseline prior to initiation of phototherapy. Difference in the measure of Shannon diversity index between plaque center vs contralateral unaffected skin.	Group 6 n=33 Participants The diversity of microbiota present in a given sample measured using the Jaccard's Diversity Index at baseline prior to initiation of phototherapy. Comparison of differences in mean between Ipsilateral distant unaffected skin vs plaque center and contralateral unaffected skin vs plaque center at baseline.
Change in Cutaneous Bacterial Load Between Baseline and Week 8.	0.53 Log10 [bacterial count/sample] Standard Error 0.20	0.85 Log10 [bacterial count/sample] Standard Error 0.41	-0.05 Log10 [bacterial count/sample] Standard Error 0.23	-0.08 Log10 [bacterial count/sample] Standard Error 0.16	-0.01 Log10 [bacterial count/sample] Standard Error 0.20	-0.01 Log10 [bacterial count/sample] Standard Error 0.18

PRIMARY outcome

Timeframe: Week 9

Bacterial count per sample at baseline prior to initiation of phototherapy vs at week 9 after initiation of phototherapy.

Outcome measures

Outcome measures
Measure	Group 1a- Plaque Center vs Plaque Edge n=34 Participants The diversity of microbiota present in a given sample measured using the Shannon Diversity Index at baseline prior to initiation of phototherapy. Difference in the measure of Shannon diversity index between plaque center vs plaque edge.	Group 1b- Plaque Center vs Ipsilateral Perilesional Unaffected n=18 Participants The diversity of microbiota present in a given sample measured using the Shannon Diversity Index at baseline prior to initiation of phototherapy. Difference in the measure of Shannon diversity index between plaque center vs ipsilateral perilesional unaffected skin	Group 1c- Plaque Center vs Ipsilateral Distant Unaffected Skin n=31 Participants The diversity of microbiota present in a given sample measured using the Shannon Diversity Index at baseline prior to initiation of phototherapy. Difference in the measure of Shannon diversity index between plaque center vs ipsilateral distant unaffected skin.	Group 1d- Ipsilateral Unaffected Skin: Perilesional vs Distant n=32 Participants The diversity of microbiota present in a given sample measured using the Shannon Diversity Index at baseline prior to initiation of phototherapy. Difference in the measure of Shannon diversity index between perilesional ipsilateral unaffected skin vs distant ipsilateral unaffected skin.	Group 1e- Plaque Center vs Contralateral Unaffected Skin n=16 Participants The diversity of microbiota present in a given sample measured using the Shannon Diversity Index at baseline prior to initiation of phototherapy. Difference in the measure of Shannon diversity index between plaque center vs contralateral unaffected skin.	Group 6 n=33 Participants The diversity of microbiota present in a given sample measured using the Jaccard's Diversity Index at baseline prior to initiation of phototherapy. Comparison of differences in mean between Ipsilateral distant unaffected skin vs plaque center and contralateral unaffected skin vs plaque center at baseline.
Change in Cutaneous Bacterial Load Between Baseline and Week 9.	0.68 Log10 [bacterial count/sample] Standard Error 0.17	0.61 Log10 [bacterial count/sample] Standard Error 0.42	-0.01 Log10 [bacterial count/sample] Standard Error 0.17	-0.01 Log10 [bacterial count/sample] Standard Error 0.15	-0.02 Log10 [bacterial count/sample] Standard Error 0.24	-0.002 Log10 [bacterial count/sample] Standard Error 0.18

Adverse Events

NB-UVB Phototherapy

Serious events: 0 serious events

Other events: 17 other events

Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Other adverse events
Measure	NB-UVB Phototherapy n=34 participants at risk NB-UVB phototherapy is a therapy which uses ultraviolet B (UVB) light directed at the skin. This type of light therapy is given through the use of phototherapy booths which contain fluorescent tubes that emit UVB light. Booths used for phototherapy look similar to commercial tanning booths. NB-UVB phototherapy affects psoriasis by causing changes to the cells of the skin and producing a local effect by reducing the number of certain types of skin cells which have an impact on psoriasis formation. NB-UVB Phototherapy
Skin and subcutaneous tissue disorders Erythema	41.2% 14/34 • 9 weeks
Skin and subcutaneous tissue disorders Tenderness	35.3% 12/34 • 9 weeks
Skin and subcutaneous tissue disorders Burn	8.8% 3/34 • 9 weeks
Skin and subcutaneous tissue disorders Pruiritis	5.9% 2/34 • 9 weeks

Additional Information

Junko Takeshita

University of Pennsylvania

Phone: 215-349-5551

Email: [email protected]

Results disclosure agreements

Principal investigator is a sponsor employee
Publication restrictions are in place