Development and Validation of Novel MRI Methods for the Detection of Prostate Cancer Aggressiveness
NCT ID: NCT02545881
Last Updated: 2016-10-19
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
200 participants
OBSERVATIONAL
2015-07-31
Brief Summary
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Detailed Description
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Diffusion weighted imaging (DWI) and rotating frame relaxation measurements have shown to be particularly promising in prostate cancer detection and characterization. This study which focuses on further development and validation of DWI and rotating frame relaxation measurements will enroll 200 men with histologically diagnosed prostate cancer who will undergo magnetic resonance imaging (MRI) before prostatectomy. Anatomical MRI and novel acquisition methods focusing on DWI and rotating frame relaxation measurements will be performed using surface coils to non-invasively detect and characterize prostate cancer.
Conditions
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Study Design
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CASE_ONLY
PROSPECTIVE
Interventions
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Magnetic Resonance Imaging (MRI)
MRI of the prostate prior to prostatectomy
Eligibility Criteria
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Inclusion Criteria
* Language spoken: Finnish
* Performance status: Karnofsky score 70 or better or WHO performance status 2 or better
* Diagnosis: Histologically confirmed adenocarcinoma of prostate
* No previous surgical, radiation or endocrine treatment for prostate carcinoma
* Clinical stage T1c-T3aN0 based on transrectal ultrasound, pelvic CT and bone scintigraphy
* Time period between the last biopsy and scheduled radical prostatectomy less than 8 months
* Mental status: Patients must be able to understand the meaning of the study
* Informed consent: The patient must sign the appropriate Ethics Committee (EC) approved informed consent documents in the presence of the designated staff
Exclusion Criteria
* symptomatic acute prostatitis
* contraindications for MRI (cardiac pacemaker, intracranial clips etc)
* uncontrolled serious infection
* claustrophobia
30 Years
85 Years
MALE
No
Sponsors
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Turku University Hospital
OTHER_GOV
Responsible Party
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Hannu Aronen
Professor, Chief Physician
Locations
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Department of Urology, Turku University Hospital
Turku, , Finland
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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Turku UH
Identifier Type: -
Identifier Source: org_study_id
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