Trial Outcomes & Findings for Validity of the Electronic Self-Administered Gerocognitive Examination (eSAGE) (NCT NCT02544074)

Results Overview

Analysis will consist of comparing the subject's scores on the SAGE in digital format to their neuropsychological test scores. This will be a composite score of the neuropsychological testing scores. The neuropsychological measures include: * Boston Naming Test * Wisconsin Card Sort Task (WCST) * Hopkins Verbal Learning Test (HVLT) * FAS verbal fluency task * Wechsler Adult Intelligence Scale III (WAIS III) Letter-number and block design subtests Associations will be investigated using Spearman correlations.

Recruitment status

COMPLETED

Target enrollment

69 participants

Primary outcome timeframe

3 Hours

Results posted on

2025-03-25

Participant Flow

The eSAGE test is scored from 0-22 with 22 indicating a perfect score.

Participant milestones

Participant milestones
Measure	eSAGE Score of 2 Participants who score a 2 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 3 Participants who score a 3 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 4 Participants who score a 4 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 5 Participants who score a 5 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 6 Participants who score a 6 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 7 Participants who score a 7 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 8 Participants who score an 8 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 9 Participants who score a 9 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 10 Participants who score a 10 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 11 Participants who score an 11 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 12 Participants who score a 12 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 13 Participants who score a 13 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 14 Participants who score a 14 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 15 Participants who score a 15 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 16 Participants who score a 16 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 17 Participants who score a 17 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 18 Participants who score a 18 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 19 Participants who score a 19 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 20 Participants who score a 20 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 21 Participants who score a 21 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 22 Participants who score a 22 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments
Overall Study STARTED	1	1	1	1	4	1	2	4	6	2	2	3	4	5	5	8	6	3	4	3	3
Overall Study COMPLETED	1	0	1	1	4	0	2	4	6	1	2	3	4	5	5	8	6	3	4	3	3
Overall Study NOT COMPLETED	0	1	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0

Reasons for withdrawal

Reasons for withdrawal
Measure	eSAGE Score of 2 Participants who score a 2 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 3 Participants who score a 3 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 4 Participants who score a 4 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 5 Participants who score a 5 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 6 Participants who score a 6 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 7 Participants who score a 7 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 8 Participants who score an 8 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 9 Participants who score a 9 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 10 Participants who score a 10 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 11 Participants who score an 11 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 12 Participants who score a 12 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 13 Participants who score a 13 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 14 Participants who score a 14 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 15 Participants who score a 15 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 16 Participants who score a 16 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 17 Participants who score a 17 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 18 Participants who score a 18 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 19 Participants who score a 19 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 20 Participants who score a 20 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 21 Participants who score a 21 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 22 Participants who score a 22 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments
Overall Study Withdrawal by Subject	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Overall Study Tablet error	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0

Baseline Characteristics

Validity of the Electronic Self-Administered Gerocognitive Examination (eSAGE)

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure	eSAGE Score of 2 n=1 Participants Participants who score a 2 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 3 n=1 Participants Participants who score a 3 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 4 n=1 Participants Participants who score a 4 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 5 n=1 Participants Participants who score a 5 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 6 n=4 Participants Participants who score a 6 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 7 n=1 Participants Participants who score a 7 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 8 n=2 Participants Participants who score an 8 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 9 n=4 Participants Participants who score a 9 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 10 n=6 Participants Participants who score a 10 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 11 n=2 Participants Participants who score an 11 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 12 n=2 Participants Participants who score a 12 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 13 n=3 Participants Participants who score a 13 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 14 n=4 Participants Participants who score a 14 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 15 n=5 Participants Participants who score a 15 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 16 n=5 Participants Participants who score a 16 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 17 n=8 Participants Participants who score a 17 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 18 n=6 Participants Participants who score a 18 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 19 n=3 Participants Participants who score a 19 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 20 n=4 Participants Participants who score a 20 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 21 n=3 Participants Participants who score a 21 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	eSAGE Score of 22 n=3 Participants Participants who score a 22 on the eSAGE. Interventions include neuropsychological testing. neuropsychological testing: standard neuropsychological testing including brief standardized assessments	Total n=69 Participants Total of all reporting groups
Age, Categorical <=18 years	0 Participants n=5 Participants	0 Participants n=7 Participants	0 Participants n=5 Participants	0 Participants n=4 Participants	0 Participants n=21 Participants	0 Participants n=8 Participants	0 Participants n=8 Participants	0 Participants n=24 Participants	0 Participants n=42 Participants	0 Participants n=42 Participants	0 Participants n=42 Participants	0 Participants n=42 Participants	0 Participants n=36 Participants	0 Participants n=36 Participants	0 Participants n=24 Participants	0 Participants n=135 Participants	0 Participants n=136 Participants	0 Participants n=44 Participants	0 Participants n=667 Participants	0 Participants n=12 Participants	0 Participants n=12 Participants	0 Participants n=12 Participants
Age, Categorical Between 18 and 65 years	0 Participants n=5 Participants	0 Participants n=7 Participants	0 Participants n=5 Participants	0 Participants n=4 Participants	0 Participants n=21 Participants	0 Participants n=8 Participants	0 Participants n=8 Participants	0 Participants n=24 Participants	0 Participants n=42 Participants	0 Participants n=42 Participants	0 Participants n=42 Participants	0 Participants n=42 Participants	0 Participants n=36 Participants	1 Participants n=36 Participants	1 Participants n=24 Participants	3 Participants n=135 Participants	0 Participants n=136 Participants	0 Participants n=44 Participants	0 Participants n=667 Participants	0 Participants n=12 Participants	1 Participants n=12 Participants	6 Participants n=12 Participants
Age, Categorical >=65 years	1 Participants n=5 Participants	1 Participants n=7 Participants	1 Participants n=5 Participants	1 Participants n=4 Participants	4 Participants n=21 Participants	1 Participants n=8 Participants	2 Participants n=8 Participants	4 Participants n=24 Participants	6 Participants n=42 Participants	2 Participants n=42 Participants	2 Participants n=42 Participants	3 Participants n=42 Participants	4 Participants n=36 Participants	4 Participants n=36 Participants	4 Participants n=24 Participants	5 Participants n=135 Participants	6 Participants n=136 Participants	3 Participants n=44 Participants	4 Participants n=667 Participants	3 Participants n=12 Participants	2 Participants n=12 Participants	63 Participants n=12 Participants
Sex: Female, Male Female	0 Participants n=5 Participants	0 Participants n=7 Participants	0 Participants n=5 Participants	1 Participants n=4 Participants	3 Participants n=21 Participants	0 Participants n=8 Participants	0 Participants n=8 Participants	3 Participants n=24 Participants	4 Participants n=42 Participants	1 Participants n=42 Participants	2 Participants n=42 Participants	2 Participants n=42 Participants	2 Participants n=36 Participants	4 Participants n=36 Participants	2 Participants n=24 Participants	7 Participants n=135 Participants	3 Participants n=136 Participants	2 Participants n=44 Participants	3 Participants n=667 Participants	2 Participants n=12 Participants	3 Participants n=12 Participants	44 Participants n=12 Participants
Sex: Female, Male Male	1 Participants n=5 Participants	1 Participants n=7 Participants	1 Participants n=5 Participants	0 Participants n=4 Participants	1 Participants n=21 Participants	1 Participants n=8 Participants	2 Participants n=8 Participants	1 Participants n=24 Participants	2 Participants n=42 Participants	1 Participants n=42 Participants	0 Participants n=42 Participants	1 Participants n=42 Participants	2 Participants n=36 Participants	1 Participants n=36 Participants	3 Participants n=24 Participants	1 Participants n=135 Participants	3 Participants n=136 Participants	1 Participants n=44 Participants	1 Participants n=667 Participants	1 Participants n=12 Participants	0 Participants n=12 Participants	25 Participants n=12 Participants
Race (NIH/OMB) American Indian or Alaska Native	0 Participants n=5 Participants	0 Participants n=7 Participants	0 Participants n=5 Participants	0 Participants n=4 Participants	0 Participants n=21 Participants	0 Participants n=8 Participants	0 Participants n=8 Participants	0 Participants n=24 Participants	0 Participants n=42 Participants	0 Participants n=42 Participants	0 Participants n=42 Participants	0 Participants n=42 Participants	0 Participants n=36 Participants	0 Participants n=36 Participants	0 Participants n=24 Participants	0 Participants n=135 Participants	0 Participants n=136 Participants	0 Participants n=44 Participants	0 Participants n=667 Participants	0 Participants n=12 Participants	0 Participants n=12 Participants	0 Participants n=12 Participants
Race (NIH/OMB) Asian	0 Participants n=5 Participants	0 Participants n=7 Participants	0 Participants n=5 Participants	0 Participants n=4 Participants	0 Participants n=21 Participants	0 Participants n=8 Participants	0 Participants n=8 Participants	0 Participants n=24 Participants	0 Participants n=42 Participants	0 Participants n=42 Participants	0 Participants n=42 Participants	0 Participants n=42 Participants	0 Participants n=36 Participants	1 Participants n=36 Participants	0 Participants n=24 Participants	0 Participants n=135 Participants	0 Participants n=136 Participants	1 Participants n=44 Participants	0 Participants n=667 Participants	0 Participants n=12 Participants	0 Participants n=12 Participants	2 Participants n=12 Participants
Race (NIH/OMB) Native Hawaiian or Other Pacific Islander	0 Participants n=5 Participants	0 Participants n=7 Participants	0 Participants n=5 Participants	0 Participants n=4 Participants	0 Participants n=21 Participants	0 Participants n=8 Participants	0 Participants n=8 Participants	0 Participants n=24 Participants	0 Participants n=42 Participants	0 Participants n=42 Participants	0 Participants n=42 Participants	0 Participants n=42 Participants	0 Participants n=36 Participants	0 Participants n=36 Participants	0 Participants n=24 Participants	0 Participants n=135 Participants	0 Participants n=136 Participants	0 Participants n=44 Participants	0 Participants n=667 Participants	0 Participants n=12 Participants	0 Participants n=12 Participants	0 Participants n=12 Participants
Race (NIH/OMB) Black or African American	0 Participants n=5 Participants	0 Participants n=7 Participants	0 Participants n=5 Participants	0 Participants n=4 Participants	1 Participants n=21 Participants	0 Participants n=8 Participants	0 Participants n=8 Participants	0 Participants n=24 Participants	0 Participants n=42 Participants	0 Participants n=42 Participants	0 Participants n=42 Participants	0 Participants n=42 Participants	0 Participants n=36 Participants	2 Participants n=36 Participants	1 Participants n=24 Participants	1 Participants n=135 Participants	0 Participants n=136 Participants	0 Participants n=44 Participants	0 Participants n=667 Participants	0 Participants n=12 Participants	0 Participants n=12 Participants	5 Participants n=12 Participants
Race (NIH/OMB) White	1 Participants n=5 Participants	1 Participants n=7 Participants	1 Participants n=5 Participants	1 Participants n=4 Participants	3 Participants n=21 Participants	1 Participants n=8 Participants	2 Participants n=8 Participants	3 Participants n=24 Participants	6 Participants n=42 Participants	2 Participants n=42 Participants	2 Participants n=42 Participants	3 Participants n=42 Participants	4 Participants n=36 Participants	2 Participants n=36 Participants	4 Participants n=24 Participants	7 Participants n=135 Participants	6 Participants n=136 Participants	2 Participants n=44 Participants	3 Participants n=667 Participants	3 Participants n=12 Participants	3 Participants n=12 Participants	60 Participants n=12 Participants
Race (NIH/OMB) More than one race	0 Participants n=5 Participants	0 Participants n=7 Participants	0 Participants n=5 Participants	0 Participants n=4 Participants	0 Participants n=21 Participants	0 Participants n=8 Participants	0 Participants n=8 Participants	0 Participants n=24 Participants	0 Participants n=42 Participants	0 Participants n=42 Participants	0 Participants n=42 Participants	0 Participants n=42 Participants	0 Participants n=36 Participants	0 Participants n=36 Participants	0 Participants n=24 Participants	0 Participants n=135 Participants	0 Participants n=136 Participants	0 Participants n=44 Participants	0 Participants n=667 Participants	0 Participants n=12 Participants	0 Participants n=12 Participants	0 Participants n=12 Participants
Race (NIH/OMB) Unknown or Not Reported	0 Participants n=5 Participants	0 Participants n=7 Participants	0 Participants n=5 Participants	0 Participants n=4 Participants	0 Participants n=21 Participants	0 Participants n=8 Participants	0 Participants n=8 Participants	1 Participants n=24 Participants	0 Participants n=42 Participants	0 Participants n=42 Participants	0 Participants n=42 Participants	0 Participants n=42 Participants	0 Participants n=36 Participants	0 Participants n=36 Participants	0 Participants n=24 Participants	0 Participants n=135 Participants	0 Participants n=136 Participants	0 Participants n=44 Participants	1 Participants n=667 Participants	0 Participants n=12 Participants	0 Participants n=12 Participants	2 Participants n=12 Participants

PRIMARY outcome

Timeframe: 3 Hours

Analysis will consist of comparing the subject's scores on the SAGE in digital format to their neuropsychological test scores. This will be a composite score of the neuropsychological testing scores. The neuropsychological measures include: * Boston Naming Test * Wisconsin Card Sort Task (WCST) * Hopkins Verbal Learning Test (HVLT) * FAS verbal fluency task * Wechsler Adult Intelligence Scale III (WAIS III) Letter-number and block design subtests Associations will be investigated using Spearman correlations.

Outcome measures

Outcome measures
Measure	eSAGE Score Compared to the Sum of Neuropsychological Measures n=66 Participants Analysis will consist of comparing the subject's scores on the SAGE in digital format to their neuropsychological test scores. This will be a composite score of the neuropsychological testing scores. The neuropsychological measures include: * Boston Naming Test * Wisconsin Card Sort Task (WCST) * Hopkins Verbal Learning Test (HVLT) * FAS verbal fluency task * Wechsler Adult Intelligence Scale III (WAIS III) Letter-number and block design subtests Associations will be investigated using Spearman correlations.	eSAGE Score Compared to the HVLT Delayed Recall Score The investigators will compare the eSAGE scores to the Hopkins Verbal Learning Test (HVLT) delayed recall scores. Associations will be investigated using Spearman correlations.
eSAGE Score Compared to the Sum of the Neuropsychological Measures.	0.7292 spearman rank correlation	—

SECONDARY outcome

Timeframe: 3 hours

The investigators will compare the subject's scores on the SAGE in digital format to their paper SAGE scores to determine if these two formats are equivalent to each other. Associations will be investigated using Spearman correlations.

Outcome measures

Outcome measures
Measure	eSAGE Score Compared to the Sum of Neuropsychological Measures n=66 Participants Analysis will consist of comparing the subject's scores on the SAGE in digital format to their neuropsychological test scores. This will be a composite score of the neuropsychological testing scores. The neuropsychological measures include: * Boston Naming Test * Wisconsin Card Sort Task (WCST) * Hopkins Verbal Learning Test (HVLT) * FAS verbal fluency task * Wechsler Adult Intelligence Scale III (WAIS III) Letter-number and block design subtests Associations will be investigated using Spearman correlations.	eSAGE Score Compared to the HVLT Delayed Recall Score The investigators will compare the eSAGE scores to the Hopkins Verbal Learning Test (HVLT) delayed recall scores. Associations will be investigated using Spearman correlations.
eSAGE Score Compared to the Paper SAGE Score	0.8824 spearman rank correlation	—

SECONDARY outcome

Timeframe: 3 hours

The investigators will compare the eSAGE scores with the Mini-Mental State Examination (MMSE) scores. Associations will be investigated using Spearman correlations.

Outcome measures

Outcome measures
Measure	eSAGE Score Compared to the Sum of Neuropsychological Measures n=66 Participants Analysis will consist of comparing the subject's scores on the SAGE in digital format to their neuropsychological test scores. This will be a composite score of the neuropsychological testing scores. The neuropsychological measures include: * Boston Naming Test * Wisconsin Card Sort Task (WCST) * Hopkins Verbal Learning Test (HVLT) * FAS verbal fluency task * Wechsler Adult Intelligence Scale III (WAIS III) Letter-number and block design subtests Associations will be investigated using Spearman correlations.	eSAGE Score Compared to the HVLT Delayed Recall Score The investigators will compare the eSAGE scores to the Hopkins Verbal Learning Test (HVLT) delayed recall scores. Associations will be investigated using Spearman correlations.
eSAGE Score Compared to the Mini-Mental State Examination (MMSE) Score	0.6711 spearman rank correlation	—

SECONDARY outcome

Timeframe: 3 hours

The investigators will compare the eSAGE scores with the Montreal Cognitive Assessment (MoCA) scores. Associations will be investigated using Spearman correlations.

Outcome measures

Outcome measures
Measure	eSAGE Score Compared to the Sum of Neuropsychological Measures n=66 Participants Analysis will consist of comparing the subject's scores on the SAGE in digital format to their neuropsychological test scores. This will be a composite score of the neuropsychological testing scores. The neuropsychological measures include: * Boston Naming Test * Wisconsin Card Sort Task (WCST) * Hopkins Verbal Learning Test (HVLT) * FAS verbal fluency task * Wechsler Adult Intelligence Scale III (WAIS III) Letter-number and block design subtests Associations will be investigated using Spearman correlations.	eSAGE Score Compared to the HVLT Delayed Recall Score The investigators will compare the eSAGE scores to the Hopkins Verbal Learning Test (HVLT) delayed recall scores. Associations will be investigated using Spearman correlations.
eSAGE Score Compared to the Montreal Cognitive Assessment (MoCA) Score	0.7577 spearman rank correlation	—

SECONDARY outcome

Timeframe: 3 hours

The investigators will compare the eSAGE scores to the Boston Naming Test score. The Boston Naming Test consists of 60 pictures of nouns that subjects must try to name. Associations will be investigated using Spearman correlations.

Outcome measures

Outcome measures
Measure	eSAGE Score Compared to the Sum of Neuropsychological Measures n=66 Participants Analysis will consist of comparing the subject's scores on the SAGE in digital format to their neuropsychological test scores. This will be a composite score of the neuropsychological testing scores. The neuropsychological measures include: * Boston Naming Test * Wisconsin Card Sort Task (WCST) * Hopkins Verbal Learning Test (HVLT) * FAS verbal fluency task * Wechsler Adult Intelligence Scale III (WAIS III) Letter-number and block design subtests Associations will be investigated using Spearman correlations.	eSAGE Score Compared to the HVLT Delayed Recall Score The investigators will compare the eSAGE scores to the Hopkins Verbal Learning Test (HVLT) delayed recall scores. Associations will be investigated using Spearman correlations.
eSAGE Score Compared to the Boston Naming Test Score	0.3487 spearman rank correlation	—

SECONDARY outcome

Timeframe: 3 hours

The investigators will compare the eSAGE scores to the Wisconsin Card Sort Task (WCST) perseverative errors scores. Associations will be investigated using Spearman correlations.

Outcome measures

Outcome measures
Measure	eSAGE Score Compared to the Sum of Neuropsychological Measures n=66 Participants Analysis will consist of comparing the subject's scores on the SAGE in digital format to their neuropsychological test scores. This will be a composite score of the neuropsychological testing scores. The neuropsychological measures include: * Boston Naming Test * Wisconsin Card Sort Task (WCST) * Hopkins Verbal Learning Test (HVLT) * FAS verbal fluency task * Wechsler Adult Intelligence Scale III (WAIS III) Letter-number and block design subtests Associations will be investigated using Spearman correlations.	eSAGE Score Compared to the HVLT Delayed Recall Score The investigators will compare the eSAGE scores to the Hopkins Verbal Learning Test (HVLT) delayed recall scores. Associations will be investigated using Spearman correlations.
eSAGE Score Compared to the Wisconsin Card Sort Task (WCST) Score	0.4596 spearman rank correlation	—

SECONDARY outcome

Timeframe: 3 hours

The investigators will compare the eSAGE scores to the Hopkins Verbal Learning Test (HVLT) total learning scores. Associations will be investigated using Spearman correlations. The investigators will also compare the eSAGE scores to the Hopkins Verbal Learning Test (HVLT) delayed recall scores. Associations will be investigated using Spearman correlations.

Outcome measures

Outcome measures
Measure	eSAGE Score Compared to the Sum of Neuropsychological Measures n=66 Participants Analysis will consist of comparing the subject's scores on the SAGE in digital format to their neuropsychological test scores. This will be a composite score of the neuropsychological testing scores. The neuropsychological measures include: * Boston Naming Test * Wisconsin Card Sort Task (WCST) * Hopkins Verbal Learning Test (HVLT) * FAS verbal fluency task * Wechsler Adult Intelligence Scale III (WAIS III) Letter-number and block design subtests Associations will be investigated using Spearman correlations.	eSAGE Score Compared to the HVLT Delayed Recall Score n=66 Participants The investigators will compare the eSAGE scores to the Hopkins Verbal Learning Test (HVLT) delayed recall scores. Associations will be investigated using Spearman correlations.
eSAGE Score Compared to the Hopkins Verbal Learning Test (HVLT) Score	0.6045 spearman rank correlation	0.4866 spearman rank correlation

SECONDARY outcome

Timeframe: 3 hours

The investigators will compare the eSAGE scores to the FAS Verbal Fluency Task scores. Associations will be investigated using Spearman correlations.

Outcome measures

Outcome measures
Measure	eSAGE Score Compared to the Sum of Neuropsychological Measures n=66 Participants Analysis will consist of comparing the subject's scores on the SAGE in digital format to their neuropsychological test scores. This will be a composite score of the neuropsychological testing scores. The neuropsychological measures include: * Boston Naming Test * Wisconsin Card Sort Task (WCST) * Hopkins Verbal Learning Test (HVLT) * FAS verbal fluency task * Wechsler Adult Intelligence Scale III (WAIS III) Letter-number and block design subtests Associations will be investigated using Spearman correlations.	eSAGE Score Compared to the HVLT Delayed Recall Score The investigators will compare the eSAGE scores to the Hopkins Verbal Learning Test (HVLT) delayed recall scores. Associations will be investigated using Spearman correlations.
eSAGE Score Compare to the FAS Verbal Fluency Task Score	0.3210 spearman rank correlation	—

SECONDARY outcome

Timeframe: 3 hours

The investigators will compare the eSAGE scores to the WAIS III Letter-number scores. The WAIS III Letter-number test asks subjects to recall a series of numbers in increasing order and letters in alphabetical order. Associations will be investigated using Spearman correlations.

Outcome measures

Outcome measures
Measure	eSAGE Score Compared to the Sum of Neuropsychological Measures n=66 Participants Analysis will consist of comparing the subject's scores on the SAGE in digital format to their neuropsychological test scores. This will be a composite score of the neuropsychological testing scores. The neuropsychological measures include: * Boston Naming Test * Wisconsin Card Sort Task (WCST) * Hopkins Verbal Learning Test (HVLT) * FAS verbal fluency task * Wechsler Adult Intelligence Scale III (WAIS III) Letter-number and block design subtests Associations will be investigated using Spearman correlations.	eSAGE Score Compared to the HVLT Delayed Recall Score The investigators will compare the eSAGE scores to the Hopkins Verbal Learning Test (HVLT) delayed recall scores. Associations will be investigated using Spearman correlations.
eSAGE Score Compared to the Wechsler Adult Intelligence Scale III (WAIS III) Letter-number Score	0.5349 spearman rank correlation	—

SECONDARY outcome

Timeframe: 3 hours

The investigators will compare the eSAGE scores to the WAIS III Block Design scores. The WAIS III Block Design requires the replication of red and white designs using three-dimensional colored blocks. Associations will be investigated using Spearman correlations.

Outcome measures

Outcome measures
Measure	eSAGE Score Compared to the Sum of Neuropsychological Measures n=66 Participants Analysis will consist of comparing the subject's scores on the SAGE in digital format to their neuropsychological test scores. This will be a composite score of the neuropsychological testing scores. The neuropsychological measures include: * Boston Naming Test * Wisconsin Card Sort Task (WCST) * Hopkins Verbal Learning Test (HVLT) * FAS verbal fluency task * Wechsler Adult Intelligence Scale III (WAIS III) Letter-number and block design subtests Associations will be investigated using Spearman correlations.	eSAGE Score Compared to the HVLT Delayed Recall Score The investigators will compare the eSAGE scores to the Hopkins Verbal Learning Test (HVLT) delayed recall scores. Associations will be investigated using Spearman correlations.
eSAGE Score Compared to the Wechsler Adult Intelligence Scale III (WAIS III) Block Design Score	0.5774 spearman rank correlation	—

Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Adverse event data not reported

Additional Information

Douglas Scharre, MD

The Ohio State University

Phone: 614-293-4969

Email: [email protected]

Results disclosure agreements

Principal investigator is a sponsor employee
Publication restrictions are in place