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Motor and Cognitive Functions in Acquired and Developmental Brain Damaged Patients

NCT ID: NCT02543424

Last Updated: 2020-10-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

400 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-04-30

Study Completion Date

2021-12-31

Brief Summary

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Neurological pathologies cause important and permanent disabilities in every day life. These pathologies can follow stoke, affecting two people per one thousand each year or cerebral palsy, affecting two births per one thousand each year. To date, the diagnosis and the rehabilitation of motor and cognitive problems has been carried out separately by different domains. For example, physiotherapists have focused on motor problems and neuropsychologists have focused on cognitive functions. However, a number of studies have demonstrated a link between motor and cognitive abilities in adults and children. The present study has three main aims: (1) to better evaluate motor and cognitive problems in brain damaged patients (all ages), (2) to understand the link between motor and cognitive abilities in patients and healthy participants and, (3) to propose new types of therapies based on the link between motor and cognitive functions.

Detailed Description

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Conditions

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Cerebral Palsy Perceptual Disorders Hemiparesis

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Patient group

Brain damaged adults with either hemiparesis and/or hemineglect. Brain damaged children with developmental and/or acquired disease inducing hemiparesis and/or hemineglect.

Group Type EXPERIMENTAL

Motor, cognitive and neuropsychological assessment

Intervention Type BEHAVIORAL

Cognitive and motor testing and/or experimental cognitive or motor changes and/or cognitive or motor rehabilitation depending on part of the study investigated.

Control group

Healthy adults and children.

Group Type SHAM_COMPARATOR

Motor, cognitive and neuropsychological assessment

Intervention Type BEHAVIORAL

Cognitive and motor testing and/or experimental cognitive or motor changes and/or cognitive or motor rehabilitation depending on part of the study investigated.

Interventions

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Motor, cognitive and neuropsychological assessment

Cognitive and motor testing and/or experimental cognitive or motor changes and/or cognitive or motor rehabilitation depending on part of the study investigated.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Congenital cerebral palsy and acquired brain injury children and adult patients
* Presenting upper limb paresis and/or hemineglect
* Between the age of 3 to 90.
* Able to understand and carry out simple verbal instruction

Exclusion Criteria

* IQ \< 70
* Severe aphasia, attentional disorder or psychiatric disorders
* Neurodegenerative disorders
Minimum Eligible Age

5 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Cliniques universitaires Saint-Luc- Université Catholique de Louvain

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Thierry Lejeune

Role: PRINCIPAL_INVESTIGATOR

St. Luc Hospital

Gaëtan Stoquart

Role: PRINCIPAL_INVESTIGATOR

St. Luc Hospital

Martin Edwards

Role: PRINCIPAL_INVESTIGATOR

Université Catholique de Louvain

Locations

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Centre Hospitalier Neurologique William Lennox

Ottignies, Brabant Wallon, Belgium

Site Status RECRUITING

Cliniques Universitaires St Luc

Woluwé-Saint-Lambert, Brussels Capital, Belgium

Site Status RECRUITING

Countries

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Belgium

Central Contacts

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Marie Alsamour

Role: CONTACT

[email protected]

Stéphanie Dehem

Role: CONTACT

[email protected]

Facility Contacts

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Sybille Andries

Role: primary

Thierry Lejeune, Pr

Role: primary

References

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Doumas I, Lejeune T, Edwards M, Stoquart G, Vandermeeren Y, Dehez B, Dehem S. Clinical validation of an individualized auto-adaptative serious game for combined cognitive and upper limb motor robotic rehabilitation after stroke. J Neuroeng Rehabil. 2025 Jan 23;22(1):10. doi: 10.1186/s12984-025-01551-w.

Reference Type DERIVED
PMID: 39849588 (View on PubMed)

Dehem S, Montedoro V, Brouwers I, Edwards MG, Detrembleur C, Stoquart G, Renders A, Heins S, Dehez B, Lejeune T. Validation of a robot serious game assessment protocol for upper limb motor impairment in children with cerebral palsy. NeuroRehabilitation. 2019;45(2):137-149. doi: 10.3233/NRE-192745.

Reference Type DERIVED
PMID: 31498135 (View on PubMed)

Montedoro V, Alsamour M, Dehem S, Lejeune T, Dehez B, Edwards MG. Robot Diagnosis Test for Egocentric and Allocentric Hemineglect. Arch Clin Neuropsychol. 2019 Jun 1;34(4):481-494. doi: 10.1093/arclin/acy062.

Reference Type DERIVED
PMID: 30084880 (View on PubMed)

Other Identifiers

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2015/10FEV/053

Identifier Type: -

Identifier Source: org_study_id