Trial Outcomes & Findings for The Use of Magnetic Brain Stimulation to Treat Obsessive Compulsive Disorder, a Pilot Study (NCT NCT02541812)

Results Overview

Yale-Brown Obsessive Compulsive Scale. Minimum value = 0. Maximum value = 40. Higher scores indicate greater severity of obsessive and compulsive symptoms.

Recruitment status

COMPLETED

Study phase

NA

Target enrollment

20 participants

Primary outcome timeframe

Recordings: baseline; after two weeks of rTMS

Results posted on

2020-09-17

Participant Flow

Participant milestones

Participant milestones
Measure	Patients Ten sessions of 1Hz repetitive Transcranial Magnetic Stimulation of the dorsal anterior cingulate cortex in patients with obsessive compulsive disorder Transcranial Magnetic Stimulation: A non-invasive method for brain stimulation	Healthy Control Subjects One session of 1Hz repetitive Transcranial Magnetic Stimulation of the dorsal anterior cingulate cortex in healthy control individuals Transcranial Magnetic Stimulation: A non-invasive method for brain stimulation
Overall Study STARTED	10	10
Overall Study COMPLETED	10	10
Overall Study NOT COMPLETED	0	0

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

Race and Ethnicity were not collected from any participant.

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure	Patients n=10 Participants Ten sessions of 1Hz repetitive Transcranial Magnetic Stimulation of the dorsal anterior cingulate cortex in patients with obsessive compulsive disorder Transcranial Magnetic Stimulation: A non-invasive method for brain stimulation	Healthy Control Subjects n=10 Participants One session of 1Hz repetitive Transcranial Magnetic Stimulation of the dorsal anterior cingulate cortex in healthy control individuals Transcranial Magnetic Stimulation: A non-invasive method for brain stimulation	Total n=20 Participants Total of all reporting groups
Age, Continuous	28.7 years STANDARD_DEVIATION 12.1 • n=10 Participants	29.5 years STANDARD_DEVIATION 12.1 • n=10 Participants	29.2 years STANDARD_DEVIATION 12.1 • n=20 Participants
Sex: Female, Male Female	8 Participants n=10 Participants	4 Participants n=10 Participants	12 Participants n=20 Participants
Sex: Female, Male Male	2 Participants n=10 Participants	6 Participants n=10 Participants	8 Participants n=20 Participants
Race and Ethnicity Not Collected	—	—	0 Participants Race and Ethnicity were not collected from any participant.
Region of Enrollment Canada	10 participants n=10 Participants	10 participants n=10 Participants	20 participants n=20 Participants

PRIMARY outcome

Timeframe: Recordings: baseline; after two weeks of rTMS

Yale-Brown Obsessive Compulsive Scale. Minimum value = 0. Maximum value = 40. Higher scores indicate greater severity of obsessive and compulsive symptoms.

Outcome measures

Outcome measures
Measure	Patients n=10 Participants Ten sessions of 1Hz repetitive Transcranial Magnetic Stimulation of the dorsal anterior cingulate cortex in patients with obsessive compulsive disorder Transcranial Magnetic Stimulation: A non-invasive method for brain stimulation	Healthy Control Subjects One session of 1Hz repetitive Transcranial Magnetic Stimulation of the dorsal anterior cingulate cortex in healthy control individuals Transcranial Magnetic Stimulation: A non-invasive method for brain stimulation
Change in Obsessive and Compulsive Symptom Severity (Yale-Brown Obsessive Compulsive Scale)	-39.4 Percent change Standard Deviation 15.4	—

SECONDARY outcome

Timeframe: Recordings: baseline; after one session of rTMS

Post-error slowing (PES) is the difference in response time on trials following an error to trials following a correct response. Higher numbers indicate more post-error slowing (i.e. longer response times following an error trial compared to following a correct trial). The outcome measure is the change in PES from baseline to following one session of rTMS.

Outcome measures

Outcome measures
Measure	Patients n=10 Participants Ten sessions of 1Hz repetitive Transcranial Magnetic Stimulation of the dorsal anterior cingulate cortex in patients with obsessive compulsive disorder Transcranial Magnetic Stimulation: A non-invasive method for brain stimulation	Healthy Control Subjects n=10 Participants One session of 1Hz repetitive Transcranial Magnetic Stimulation of the dorsal anterior cingulate cortex in healthy control individuals Transcranial Magnetic Stimulation: A non-invasive method for brain stimulation
Change in Post-error Slowing	1.4 ms Standard Deviation 5.8	-3.0 ms Standard Deviation 4.8

Adverse Events

Patients

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Healthy Control Subjects

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Adverse event data not reported

Additional Information

Dr. Mandana Modirrousta

University of Manitoba

Phone: 2042372303

Email: [email protected]

Results disclosure agreements

Principal investigator is a sponsor employee
Publication restrictions are in place