Bioequivalence Study of Rivaroxaban

NCT ID: NCT02537457

Last Updated: 2015-09-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-01-31

Study Completion Date

2014-04-30

Brief Summary

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The objectives of this study are to establish the bioequivalence between rivaroxaban tablet 15 mg and rivaroxaban granule formulation 15 mg, and to assess the safety and tolerability of rivaroxaban 15 mg in healthy adult male subjects.

Detailed Description

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Conditions

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Embolism, Atrial Fibrillation and Venous Thrombosis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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BAY59-7939 Rivaroxaban granule

Group Type EXPERIMENTAL

Rivaroxaban (BAY 59-7939)

Intervention Type DRUG

Rivaroxaban granule15mg for one day

BAY59-7939 Rivaroxaban tablet

Group Type ACTIVE_COMPARATOR

Rivaroxaban (Xarelto, BAY 59-7939)

Intervention Type DRUG

Rivaroxaban tablet15mg for one day

Interventions

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Rivaroxaban (BAY 59-7939)

Rivaroxaban granule15mg for one day

Intervention Type DRUG

Rivaroxaban (Xarelto, BAY 59-7939)

Rivaroxaban tablet15mg for one day

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Japanese healthy male subjects
* 20 to 40 years of age
* 17.6 to 26.4 kg / m² of body mass index (BMI)

Exclusion Criteria

* Subject with incompletely cured pre-existing diseases for which it can be assumed that the absorption, distribution, metabolism, elimination and effects of the study drugs will not be normal
* Subject with a history of relevant diseases of vital organs, of the central nervous system or other organs, eg instable coronary heart disease, heart failure, liver failure, kidney failure, hypotension, or history of stroke or myocardial infarction
* Subject with known coagulation disorders (eg von Willebrand's disease, hemophilia)
* Subject with known disorders with increased bleeding risk (eg periodontosis, hemorrhoids, acute gastritis, peptic ulcer)
* Subject with known sensitivity to common causes of bleeding (eg nasal)
Minimum Eligible Age

20 Years

Maximum Eligible Age

40 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Bayer

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Bayer Study Director

Role: STUDY_DIRECTOR

Bayer

Locations

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Kumamoto, Kumamoto, Japan

Site Status

Countries

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Japan

Other Identifiers

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17017

Identifier Type: -

Identifier Source: org_study_id

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