Use-Results Surveillance Study of Sovaldi® Plus Copegus® in Japanese Patients With Chronic Genotype 2 Hepatitis C Virus Infection

NCT ID: NCT02537379

Last Updated: 2017-06-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

552 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-09-15

Study Completion Date

2017-06-05

Brief Summary

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This post-marketing surveillance (PMS) study for Sovaldi® tablets (sofosbuvir, SOF) administered in combination with Copegus® tablets (ribavirin, COPE) will evaluate the safety and efficacy of SOF administered in combination with ribavirin under real world use in Japan. Among adult patients with chronic genotype 2 hepatitis C virus (HCV) infection and treated with SOF+ribavirin in routine clinical use, the primary objective of this study is to evaluate the incidence of adverse drug reactions (ADRs) under real world settings.

Detailed Description

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Conditions

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Hepatitis C Virus Infection

Study Design

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Observational Model Type

ECOLOGIC_OR_COMMUNITY

Study Time Perspective

PROSPECTIVE

Study Groups

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SOF+COPE

Adult patients with genotype 2 chronic HCV infection with or without compensated cirrhosis who take SOF+COPE as part of routine clinical care at a participating clinical site.

SOF

Intervention Type DRUG

SOF 400 mg tablets administered orally once daily

COPE

Intervention Type DRUG

COPE tablets administered orally in a divided daily weight-based dose according to the package insert for the approved Copegus® labeling in Japan (\< 60 kg = 600 mg , \> 60 kg to ≤ 80 kg = 800 mg, and \> 80 kg = 1000 mg)

Interventions

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SOF

SOF 400 mg tablets administered orally once daily

Intervention Type DRUG

COPE

COPE tablets administered orally in a divided daily weight-based dose according to the package insert for the approved Copegus® labeling in Japan (\< 60 kg = 600 mg , \> 60 kg to ≤ 80 kg = 800 mg, and \> 80 kg = 1000 mg)

Intervention Type DRUG

Other Intervention Names

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Sovaldi® GS-7977 PSI-7977 Copegus® Ribavirin

Eligibility Criteria

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Inclusion Criteria

* Adult patients with serogroup 2 (genotype 2) chronic HCV infection with or without compensated cirrhosis
* Patients who are prescribed SOF+COPE

Exclusion Criteria

* None
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Chugai Pharmaceutical

INDUSTRY

Sponsor Role collaborator

Gilead Sciences

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Gilead Study Director

Role: STUDY_DIRECTOR

Gilead Sciences

Locations

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Amagasaki-shi, , Japan

Site Status

Asahi-shi, , Japan

Site Status

Asahikawa-shi, , Japan

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Beppu-shi, , Japan

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Chichibu-shi, , Japan

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Fujioka-shi, , Japan

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Fukui-shi, , Japan

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Hamamatsu, , Japan

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Iizuka-shi, , Japan

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Inzai-shi, , Japan

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Ishinomaki-shi, , Japan

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Iwaki, , Japan

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Izunokuni-shi, , Japan

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Kahoku-gun, , Japan

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Kanazawa, , Japan

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Kirishima-shi, , Japan

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Kisarazu-shi, , Japan

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Kitamoto-shi, , Japan

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Kobe, , Japan

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Koshigaya-shi, , Japan

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Kure-shi, , Japan

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Moriguchi-shi, , Japan

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Nagakute-shi, , Japan

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Nagaoka-shi, , Japan

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Nagasaki, , Japan

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Nagoya, , Japan

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Nakagami-gun, , Japan

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Nanto-shi, , Japan

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Nishinomiya-shi, , Japan

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Ofukeshi, , Japan

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Okayama, , Japan

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Ome-shi, , Japan

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Osaka, , Japan

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Ōta-ku, , Japan

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Sapporo, , Japan

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Sasebo-Shi, , Japan

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Sendai, , Japan

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Shinagawa-ku, , Japan

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Shinjuku-ku, , Japan

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Tokorozawa-shi, , Japan

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Tokushima, , Japan

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Wakayama, , Japan

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Yachiyo-shi, , Japan

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Yokohama, , Japan

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Yufu-shi, , Japan

Site Status

Countries

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Japan

Other Identifiers

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GS-US-334-1444 / COPE1501

Identifier Type: -

Identifier Source: org_study_id

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