TDCS and Cognitive Retraining to Augment Pharmacotherapy for the Treatment of Nicotine Dependence
NCT ID: NCT02534454
Last Updated: 2018-05-17
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
86 participants
INTERVENTIONAL
2015-08-15
2018-03-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
FACTORIAL
TREATMENT
TRIPLE
Study Groups
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Active TDCS + Active Retraining
2.0 milliamperes (mA) of transcranial direct current stimulation (TDCS) applied during active nicotine avoidance retraining
Active Retraining
Active transcranial direct current stimulation (TDCS)
Nicotine Replacement Therapy (Habitrol)
Administration of Nicotine Replacement Therapy Patches
Sham TDCS + Active Retraining
0.1 mA of transcranial direct current stimulation (TDCS) applied during active nicotine avoidance retraining
Active Retraining
Sham transcranial direct current stimulation (TDCS)
Nicotine Replacement Therapy (Habitrol)
Administration of Nicotine Replacement Therapy Patches
Active TDCS + Sham retraining
2.0 mA of transcranial direct current stimulation (TDCS) applied during sham nicotine avoidance retraining
Sham Retraining
Active transcranial direct current stimulation (TDCS)
Nicotine Replacement Therapy (Habitrol)
Administration of Nicotine Replacement Therapy Patches
Sham TDCS + Sham Retraining
0.1 mA of transcranial direct current stimulation (TDCS) applied during sham nicotine avoidance retraining
Sham Retraining
Sham transcranial direct current stimulation (TDCS)
Nicotine Replacement Therapy (Habitrol)
Administration of Nicotine Replacement Therapy Patches
Interventions
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Active Retraining
Sham Retraining
Active transcranial direct current stimulation (TDCS)
Sham transcranial direct current stimulation (TDCS)
Nicotine Replacement Therapy (Habitrol)
Administration of Nicotine Replacement Therapy Patches
Eligibility Criteria
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Inclusion Criteria
* Able to provide informed consent
* Less than 3 months smoking abstinence in the past year
* Right Handed
Exclusion Criteria
* Significant cardiovascular disease (e.g. recent stroke or heart attack, arrhythmias, worsening angina pectoris, uncontrolled hypertension) generalized skin disorders, or sensitivity to the nicotine patch
* Use of illicit drugs (excluding marijuana) in the previous 30 days
* Psychosis, psychotic disorder, or bipolar disorder
* Current active major depression (depressive episode within last month)
* Clinically significant suicidal ideation
* Prior seizure
* Current bupropion or tricyclic antidepressants
* Current pregnancy, trying to become pregnant, or breastfeeding
* Current active alcohol dependence (symptoms in last 30 days)
* Left-handedness
* Current medication known to interact with nicotine replacement therapy (NRT) or smoking cessation (e.g. adenosine, cimetidine, conivaptan, cyproterone, peginterferon alfa-2bg, tocilizumab, theophylline)
* Metal in the head
* Implanted brain medical devices
* Electromedical devices
* Latex Allergy
18 Years
60 Years
ALL
No
Sponsors
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National Institute on Drug Abuse (NIDA)
NIH
The Mind Research Network
OTHER
Responsible Party
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Locations
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The Mind Research Network
Albuquerque, New Mexico, United States
Countries
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Other Identifiers
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20547
Identifier Type: -
Identifier Source: org_study_id
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