The Effect of Remote Ischemic Preconditioning on Physical Performance and Exertional Rhabdomyolysis
NCT ID: NCT02518724
Last Updated: 2015-12-24
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
30 participants
INTERVENTIONAL
2016-01-31
2016-12-31
Brief Summary
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Detailed Description
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The experiment protocol consist 2 series (with a month between them), both series include the described 3 days:
Day 1 - anthropometry measurements and VO2max test (BRUCE protocol). Day 2 - steps test (heled protocol). Day 3 - anaerobic test (wingate protocol), 1 hour rest and time to exhaustion test (heled protocol).
The first series will be performed without applying any intervention and is considered as baseline measurements for both groups. the second series will be performed as follows: a. RIPC group: applying RIPC exposure (placing a sphygmomanometer on the non-dominant hand and applying pressure of 200 mmHg for 5 min followed by 5 min without pressure X 4 repeats) at the beginning of every meeting. b. control group: with placebo (false) exposure (placing a sphygmomanometer on the non-dominant hand and applying pressure of 100 mmHg for 5 min followed by 5 min without pressure X 4 repeats) at the beginning of every meeting.
Blood ample, lactic acid and urine sample will be tested at the beginning and end of every meeting (testing for muscle, skeleton and kidney function markers).
Conditions
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
DOUBLE
Study Groups
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RIPC intervention group
The experiment protocol consist 2 series (with a month between them), both series include the described 3 days:
Day 1 - anthropometry measurements and VO2max test (BRUCE protocol). Day 2 - steps test (heled protocol). Day 3 - anaerobic test (wingate protocol), 1 hour rest and time to exhaustion test (heled protocol).
the second series will be performed after RIPC intervention exposure at the beginning of every meeting.
RIPC intervention exposure
placing a sphygmomanometer on the non-dominant hand and applying pressure of 200 mmHg for 5 min followed by 5 min without pressure X 4 repeats
false exopsure group
The experiment protocol consist 2 series (with a month between them), both series include the described 3 days:
Day 1 - anthropometry measurements and VO2max test (BRUCE protocol). Day 2 - steps test (heled protocol). Day 3 - anaerobic test (wingate protocol), 1 hour rest and time to exhaustion test (heled protocol).
the second series will be performed after placebo intervention exposure at the beginning of every meeting.
placebo intervention exposure
placing a sphygmomanometer on the non-dominant hand and applying pressure of 100 mmHg for 5 min followed by 5 min without pressure X 4 repeats.
Interventions
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RIPC intervention exposure
placing a sphygmomanometer on the non-dominant hand and applying pressure of 200 mmHg for 5 min followed by 5 min without pressure X 4 repeats
placebo intervention exposure
placing a sphygmomanometer on the non-dominant hand and applying pressure of 100 mmHg for 5 min followed by 5 min without pressure X 4 repeats.
Eligibility Criteria
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Inclusion Criteria
* healthy civilians volunteers
* with no background illnesses
* above average fitness
Exclusion Criteria
* routine medication usage
* history of rhabdomyolysis
* the physician decision
18 Years
30 Years
MALE
Yes
Sponsors
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Sheba Medical Center
OTHER_GOV
Responsible Party
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Principal Investigators
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Ofir Frenkel, M.D
Role: PRINCIPAL_INVESTIGATOR
Sheba Medical Center
Locations
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Sheba medical center
Tel Litwinsky, Ramat- Gan, Israel
Countries
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Central Contacts
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Other Identifiers
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SHEBA-15-2139-OF-CTIL
Identifier Type: -
Identifier Source: org_study_id