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Wine Consumption and Glycemic Control

NCT ID: NCT02518334

Last Updated: 2017-10-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

14 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-03-31

Study Completion Date

2015-03-31

Brief Summary

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Many studies have reported that alcoholic beverage consumption, especially in the form of wine, reduces the risk of developing type 2 diabetes by as much as 40%. This association suggests that wine consumption may somehow improve the body's ability to control its blood glucose concentration. Indeed, it has been reported that when wine is consumed immediately prior to ingestion of glucose, the release of insulin is enhanced and blood glucose concentration is lowered. The mechanism of wine's effects on blood glucose concentration is unknown, but is likely related to its ethanol or antioxidant content. In this study, the investigators plan to test whether wine or plain ethanol (vodka) ingestion alters the control of blood glucose in subjects who have diabetes or pre-diabetes.

Detailed Description

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Our central hypothesis is that improvement in glycemic control by acute consumption of wine is mediated by ethanol. Subjects will have type 2 diabetes, pre-diabetes, and be sedentary and obese (BMI \>30). Subjects' glycemic control will be assessed by an oral glucose tolerance test (OGTT) at three different time points. One OGTT will occur shortly after consumption of red wine, the second after consumption of vodka containing the identical amount of ethanol as the wine treatment, and the third OGTT will occur shortly after consumption of an equal volume of water. The three OGTTs will be administered in random order.

Conditions

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Diabetes Mellitus, Type 2

Keywords

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type two diabetes glycemic control

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Alcohol consumption

Alcohol consumption and wine consumption

Group Type EXPERIMENTAL

Alcohol consumption

Intervention Type OTHER

28 grams (2 drinks) of ethanol will be consumed either in the form of wine or vodka.

Interventions

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Alcohol consumption

28 grams (2 drinks) of ethanol will be consumed either in the form of wine or vodka.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* insulin resistant: diagnosed with pre-diabetes or fasting blood glucose \>/= 97 mg/dL
* T2D: diagnosed by primary care physician
* at risk of type 2 diabetes (obesity and physically inactive)
* age: 21-65

Exclusion Criteria

* smoking
* insulin use (other than once daily)
* physically active (\>30 mins aerobic exercise two days/week)
* recent (\>3 mo) changes in medication use or dose
* uncontrolled type two diabetes (HbA1C \>10%)
* advanced retinopathy or neuropathy
* pregnancy
Minimum Eligible Age

21 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Missouri-Columbia

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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John P Thyfault, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Missouri-Columbia

Locations

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University of Missouri

Columbia, Missouri, United States

Site Status

Countries

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United States

References

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Avogaro A, Watanabe RM, Dall'Arche A, De Kreutzenberg SV, Tiengo A, Pacini G. Acute alcohol consumption improves insulin action without affecting insulin secretion in type 2 diabetic subjects. Diabetes Care. 2004 Jun;27(6):1369-74. doi: 10.2337/diacare.27.6.1369.

Reference Type BACKGROUND
PMID: 15161790 (View on PubMed)

Other Identifiers

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Wine and GC

Identifier Type: -

Identifier Source: org_study_id