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ARTEMIS Synovial Markers in Arthritis Childhood

NCT ID: NCT02505828

Last Updated: 2020-12-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-04-30

Study Completion Date

2018-04-30

Brief Summary

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The aim of this study is to find markers that could differentiate infectious and inflammatory arthritis. The investigators want to find markers by differential analysis by compare synovial fluids of septic and inflammatory arthritis. The investigators will use for this analysis, proteomics, cytokine dosage and monocyte typing by flow cytometry analysis. The investigators will use one marker or a score with biological and clinical data to discriminate arthritis of infectious and inflammatory etiology.

Detailed Description

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Conditions

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Septic Arthritis Juvenile Idiopathic Arthritis

Keywords

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Arthritis septic Juvenile idiopathic arthritis diagnosis proteomic cytokine monocytes

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

SINGLE

Participants

Study Groups

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Septic arthritis

with bacteriological identification

Group Type OTHER

Articular punction, salivary samples, blood sample

Intervention Type PROCEDURE

Juvenile idiopathic arthritis

beyond the ILAR (International League of Associations for Rheumatology) definition

Group Type OTHER

Articular punction, salivary samples, blood sample

Intervention Type PROCEDURE

Interventions

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Articular punction, salivary samples, blood sample

Intervention Type PROCEDURE

Other Intervention Names

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Proteomic analysis Cytokine dosage Monocyte

Eligibility Criteria

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Inclusion Criteria

* Septic arthritis with bacteriological identification
* Juvenile idiopathic arthritis beyond the ILAR definition
* Having acute arthritis requiring an articular draining
* Child benefiting from a national insurance scheme
* Collection of the consent of the parents or the legal representative

Exclusion Criteria

* Contraindication in an articular draining: platelet 50 000 / mm3, Rate of prothrombins lower than 70 %, activated partial thromboplastin times (APTT)\> 1,5
* Treatment by biotherapy, corticoids or other immuno suppressor in the month preceding the articular draining.
* Treatment by antibiotic begun more than 24 hours before the draining.
Minimum Eligible Age

6 Months

Maximum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Montpellier

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Eric EJ JEZIORSKI, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Montpellier University Hospital

Locations

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Hôpital Arnaud de Villeneuve

Montpellier, , France

Site Status

Countries

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France

References

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Nziza N, Jeziorski E, Delpont M, Cren M, Chevassus H, Carbasse A, Mahe P, Abassi H, Joly-Monrigal P, Schordan E, Mange A, Jorgensen C, Apparailly F, Duroux-Richard I. Synovial-Fluid miRNA Signature for Diagnosis of Juvenile Idiopathic Arthritis. Cells. 2019 Nov 26;8(12):1521. doi: 10.3390/cells8121521.

Reference Type RESULT
PMID: 31779271 (View on PubMed)

Cren M, Nziza N, Carbasse A, Mahe P, Dufourcq-Lopez E, Delpont M, Chevassus H, Khalil M, Mura T, Duroux-Richard I, Apparailly F, Jeziorski E, Louis-Plence P. Differential Accumulation and Activation of Monocyte and Dendritic Cell Subsets in Inflamed Synovial Fluid Discriminates Between Juvenile Idiopathic Arthritis and Septic Arthritis. Front Immunol. 2020 Jul 31;11:1716. doi: 10.3389/fimmu.2020.01716. eCollection 2020.

Reference Type RESULT
PMID: 32849606 (View on PubMed)

Other Identifiers

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2014-A01561-46

Identifier Type: REGISTRY

Identifier Source: secondary_id

93612

Identifier Type: -

Identifier Source: org_study_id