CKD-391 Pharmacokinetic Study Phase I

NCT ID: NCT02501200

Last Updated: 2016-12-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

46 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-08-31

Study Completion Date

2015-12-31

Brief Summary

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A randomized, open-label, 2-way crossover study to compare the pharmacokinetics and safety CKD-391 to coadministration Atorvastatin and Ezetimibe in health volunteers.

Detailed Description

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To compare the CKD-391 (Experimental product) to the dose Atorvastatin calcium and Ezetimibe combination in health male subjects is the purpose of this trial.

Following are evaluated in this trial; Characteristics and safety/Tolerability Of CKD-391.

Conditions

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Healthy

Keywords

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Dyslipidemia CKD-391 Atorvastatin Ezetimibe

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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TR group

CKD-391 and combination dose of Atrovastatin and Ezetimibe in order

Group Type EXPERIMENTAL

CKD-391

Intervention Type DRUG

Investigational product is prescribed to all of randomized subjects for two times.

Atrovastatin and Ezetimibe combination therapy

Intervention Type DRUG

Investigational products are prescribed to all of radomized subjects for two times.

RT group

combination dose of Atrovastatin and Ezetimibe and CKD-391 in order

Group Type EXPERIMENTAL

CKD-391

Intervention Type DRUG

Investigational product is prescribed to all of randomized subjects for two times.

Atrovastatin and Ezetimibe combination therapy

Intervention Type DRUG

Investigational products are prescribed to all of radomized subjects for two times.

Interventions

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CKD-391

Investigational product is prescribed to all of randomized subjects for two times.

Intervention Type DRUG

Atrovastatin and Ezetimibe combination therapy

Investigational products are prescribed to all of radomized subjects for two times.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Bwt \>=50kg, BMI 18.5\~25
* signed the informed consent form prior to the study participation

Exclusion Criteria

* \- Clinically significant disease
* Subject has signs of symptoms of acute disease within 28 days of starting administration of investigational drug
* Clinically significant allergic disease
* Impossible to taking the institutional standard meal
* Previously donate whole blood within 60 days or component blood within 20 days
* Previously participated in other trial within 90 days
* Continued to be taking caffeine (caffeine \> 5 cup/day), drinking(alcohol \> 30 g/day) or cannot stop drinking or severe heavy smoker(cigarette \> 10 cigarettes per day)during clinical trials
* An impossible one who participates in clinical trial by investigator's decision including laboratory test result
Minimum Eligible Age

19 Years

Maximum Eligible Age

45 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Chong Kun Dang Pharmaceutical

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Choon Ok Kim, Ph.D

Role: PRINCIPAL_INVESTIGATOR

Severance Hospital

Other Identifiers

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152BE15026

Identifier Type: -

Identifier Source: org_study_id