Clinical Trial to Evaluate the Efficacy and Safety of CKD-342

NCT ID: NCT02498509

Last Updated: 2016-12-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

459 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-05-31

Study Completion Date

2016-05-31

Brief Summary

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Clinical Trial to Evaluate the Efficacy and Safety of CKD-342

Detailed Description

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A Randomized, Double-blind, Active-controlled, Multicenter phase 3 Clinical trial to evaluate the Efficacy and Safety of Concomitant Mometasone furoate and Levocabastine HCl in Perennial Allergic Rhinitis patients

Conditions

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Rhinitis, Allergic, Perennial

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Treatment

CKD-342

Group Type EXPERIMENTAL

CKD-342

Intervention Type DRUG

treatment for 4 weeks after randomization

Control 1

Mometasone furoate

Group Type ACTIVE_COMPARATOR

Mometasone furoate

Intervention Type DRUG

treatment for 4 weeks after randomization

Control 2

Levocabastine HCL

Group Type ACTIVE_COMPARATOR

Levocabastine HCL

Intervention Type DRUG

treatment for 4 weeks after randomization

Interventions

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CKD-342

treatment for 4 weeks after randomization

Intervention Type DRUG

Mometasone furoate

treatment for 4 weeks after randomization

Intervention Type DRUG

Levocabastine HCL

treatment for 4 weeks after randomization

Intervention Type DRUG

Other Intervention Names

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investigational product investigational product investigational product

Eligibility Criteria

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Inclusion Criteria

1. male, female, Age: over 13 years(no age limiation in upper)
2. subject who has experienced perennial allergic rhinitis for over 1 year
3. subject who has identified allergens throughout the year within 12 months
4. subject who has the symptoms of moderate to severe allergic rhinitis
5. subject who can record the the patient diary during the clinical trial period
6. subject who agreed to keep the same environment during the clinical trial period

Exclusion Criteria

1. Asthma
2. Previous medical history at screening (Nasal polyps within the previous two months, biopsies, ulcers, trauma, surgery, atrophic rhinitis, patients with a history of drug rhinitis)
3. Patients with untreated localized infection in nasal mucosa
4. Patients following administration of a combination of prohibited drugs in patients administered concomitant medications or trial period is expected to be inevitable
5. Patients with abnormal following laboratory test results at screening

* AST, ALT\>2times the upper limit of normal at screening
* Serum creatinine \>1.5times the upper limit of normal at screening
6. Previous history of acute or severe chronic sinusitis within 30 days at screening
7. The continue use of drugs that may affect the efficacy of the Investigational product
8. Start the immunotherapy or a change of doge within 1 month, at screening
9. If you have glaucoma or cataracts, herpes simplex, or around the eyes
10. Chronic obstructive pulmonary disease (COPD)
11. history of hypersensitivity reactions and for treaties or major components of the IP
12. Pregnant women, breast feeding women or women of childbearing potential must agree to use appropriate contraception methods
13. Alcohol or illegal drug abuse or dependence in patients
14. participation in any investigational or maketed drug within 4weeks preceding the screening visit
15. Patients that can not be participating in a clinical trial by investigator's discretion
Minimum Eligible Age

13 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Chong Kun Dang Pharmaceutical

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Samsung Medical Center

Irwon-dong, Gangnam-gu, Seoul, South Korea

Site Status

Countries

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South Korea

Other Identifiers

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153PAR14017

Identifier Type: -

Identifier Source: org_study_id