The Impact of Insulin Therapy on Protein Turnover in Pre-Diabetic Cystic Fibrosis Patients

NCT ID: NCT02496780

Last Updated: 2025-03-17

Basic Information

• Recruitment Status: TERMINATED
• Clinical Phase: PHASE2/PHASE3
• Total Enrollment: 65 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2015-08-31
• Study Completion Date: 2022-07-31

Brief Summary

Insulin replacement therapy may be effective in breaking the cycle of protein catabolism, undernutrition and overall clinical deterioration in pre-diabetic, insulin insufficient CF youth because of its potent anabolic effect. A significant number of CF patients might benefit from this therapeutic approach with a substantial impact on morbidity and mortality.

Detailed Description

Insulin insufficiency related to pancreatic fibrosis and β-cell dysfunction is present in almost every cystic fibrosis (CF) patient. Progressive abnormalities in insulin secretion begin in childhood, and, in adults, CF related diabetes (CFRD) is eventually present in more than half of the CF population. CFRD is associated with weight loss, protein catabolism, loss of lean body mass (LBM), and early death from lung disease and malnutrition. The negative consequences of diabetes are just the "tip of the iceberg", since clinical deterioration has been documented to begin in the pre-diabetic period. Non-diabetic glucose tolerance abnormalities in CF are associated with protein catabolism, weight loss and lung function decline, all of which correlate with the severity of insulin secretory defects, suggesting a key pathologic role for insulin insufficiency. Insulin is a potent anabolic hormone, critical for maintenance of body weight and muscle mass. In a placebo-controlled clinical trial, insulin therapy improved body mass index (BMI) and LBM in patients with very early CFRD (CFRD without fasting hyperglycemia), and this is now standard care for these patients. There is growing preliminary evidence that insulin therapy is beneficial even earlier, in CF patients with pre-diabetes due to insulin insufficiency. Given the universal prevalence of insulin insufficiency in CF, the high lifetime risk of developing diabetes, the clinical impact of insulin insufficiency on protein catabolism and survival in CF, and the critical importance of maintaining body weight and LBM in this population, there is an urgent need to determine whether insulin replacement therapy should be instituted for anabolic purposes prior to the actual onset of diabetes and, if so, to ascertain the optimal regimen. The current protocol describes a double-blind, placebo-controlled trial to determine whether insulin therapy improves protein catabolism in youth with CF and abnormal glucose tolerance, and to explore differences in efficacy between multiple daily pre-meal insulin dosing (as is currently standard for early CFRD) versus a more convenient once daily basal insulin dose (as has been used in small uncontrolled pilot studies). The findings of this study will provide a mechanistic rationale for instituting insulin in youth with CF and pre-diabetes, and will inform both research studies and clinical practice as to the best regimen for insulin delivery in this population.

Conditions

Cystic Fibrosis

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: TRIPLE

Study Groups

placebo

once or 3x daily injectable placebo (insulin diluent)

Group Type: PLACEBO_COMPARATOR

placebo

Intervention Type: DRUG

once or 3x daily

basal insulin levemir

once daily basal insulin therapy with insulin levemir

Group Type: EXPERIMENTAL

levemir insulin

Intervention Type: DRUG

basal insulin once a day

rapid-acting insulin Novolog

pre-meal rapid-acting insulin 3x/day with insulin novolog

Group Type: EXPERIMENTAL

novolog insulin

Intervention Type: DRUG

3x daily rapid-acting insulin

Healthy controls

Healthy controls matched by age, gender and BMI to CF participants. These participants are only used for baseline information, no intervention or outcome measure collected

Group Type: NO_INTERVENTION

No interventions assigned to this group

Interventions

novolog insulin

3x daily rapid-acting insulin

Intervention Type: DRUG

levemir insulin

basal insulin once a day

Intervention Type: DRUG

placebo

once or 3x daily

Intervention Type: DRUG

Other Intervention Names

apart; detemir; insulin diluent

Eligibility Criteria

Inclusion Criteria

1. Diagnosis of cystic fibrosis, age 10-25 years

2. A standard routine annual OGTT performed within 12 months of randomization

3. Abnormal glucose tolerance, with a fasting glucose level <126 mg/dl and

• The 1-hr OGTT glucose is ≥200 mg/dl but the 2-hr glucose is <140 (INDET), OR
• The 2-hour OGTT glucose is 140-199 mg/dl (impaired glucose tolerance, IGT).

Exclusion Criteria

1. Diagnosis of CFRD, Consensus Conference definition (45)

2. Previous organ transplant, or transplant imminent during study period

3. BMI percentile >95

4. Treatment with systemic glucocorticoids (nasal or inhaled glucocorticoids are acceptable)

5. Therapy with growth hormone or Megace

6. Nighttime continuous drip gastrostomy/jejunostomy feedings

7. Pregnancy or breast-feeding or plans to become pregnant during study period

8. Any change in medications during the 3 months prior to the study

• Exception: the new corrector/potentiator combination drug lumacaftor/ivacaftor is expected to get FDA approval in early 2015, and most CF patients with severe genotypes, including many eligible for this proposal, will receive this drug. This is not a contraindication to participation in the current proposal (and participation in other studies is not contraindicated in the PROSPECT post-marketing drug study). Though the primary effects of the combination therapy appear to be apparent after 1 month, we will wait 6 months after initiation of lumacaftor/ivacaftor before enrollment in this study to make sure subjects are in a steady state.

9. Any anticipated change in medication during the 3 month study period

10. Acute illness in the 6 weeks prior to enrollment

• Minimum Eligible Age: 10 Years
• Maximum Eligible Age: 25 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University of Minnesota

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Antoinette Moran, MD

Role: PRINCIPAL_INVESTIGATOR

University of Minnesota

Locations

University of Minnesota

Minneapolis, Minnesota, United States

Children's Hospitals and Clinics of Minnesota

Saint Paul, Minnesota, United States

Countries

United States

Provided Documents

Document Type: Study Protocol and Statistical Analysis Plan

View Document

Document Type: Informed Consent Form

View Document

Other Identifiers

PEDS-2015-23490

Identifier Type: -

Identifier Source: org_study_id