Physical Functioning Throughout Lung Cancer Treatment

NCT ID: NCT02493114

Last Updated: 2025-09-15

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 150 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2015-07-31
• Study Completion Date: 2024-10-31

Brief Summary

This trial investigates the impact of lung cancer treatment on physical status, symptoms and quality of life. Furthermore this trial investigates possible underlying causes and consequences of deconditioning.

Detailed Description

Preliminary evidence suggests that patients with lung cancer experience a decrease of exercise tolerance and muscle strength during the course of their treatment. The underlying mechanisms and impact of this change has not yet been investigated. In light of this, our trial will prospectively follow a convenience sample of 150 patients with lung cancer who are undergoing treatment. Patients will be assessed before, during and at the end of the treatment (surgery and/or chemotherapy and/or radiotherapy and/or immunotherapy). The aims of the study are to

1. Investigate physical status, before start of treatment in lung cancer patients in comparison with healthy controls (primary outcome).

2. Investigate changes in physical status over the course of treatment in lung cancer patients (primary outcome).

3. Investigate the relationship between changes in physical status with physical activity and symptoms during treatment for lung cancer (secondary outcome).

4. Investigate the relationship between physical status after treatment for lung cancer and comorbidities, hospitalizations and cancer-related and all-cause mortality (exploratory outcome).

Conditions

Lung Cancer; Exercise Capacity; Physical Activity; Quality of Life

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Patients with lung cancer

No study intervention

No interventions assigned to this group

Healthy controls

No study intervention

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• undergoing treatment (surgery, chemotherapy, immunotherapy, radiotherapy, and combination of the previous ones)
• WHO performance status of maximal 2

Exclusion Criteria

• presence of other neoplasms in the last 2 years
• bone metastasis
• progressive neuromuscular and neurological diseases
• unstable cardiac disease
• pulmonary hypertension
• interstitial lung disease
• orthopedic conditions that significantly impair functional status
• mental or psychiatric disorders that impair the ability to comply with study procedures.
• a history of cerebrovascular accident with remaining functional consequences
• a history of lung cancer
• difficulties in understanding and speaking Dutch

• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Hasselt University

OTHER

Sponsor Role: lead

Responsible Party

Chris Burtin

Dr

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Ziekenhuis Oost-Limburg

Genk, , Belgium

Countries

Belgium

References

Quadflieg K, Arents E, Haesevoets S, Van Hulle F, Hermans F, Criel M, Daenen M, Derom E, Spruit MA, Surmont V, Stevens D, Ruttens D, Demeyer H, Burtin C. Impact of cancer treatment on physical functioning, symptoms and health-related quality of life in patients with non-small cell lung cancer: A longitudinal observational study. Respir Med. 2025 Oct;247:108283. doi: 10.1016/j.rmed.2025.108283. Epub 2025 Jul 31.

Reference Type: DERIVED

PMID: 40752628 (View on PubMed)

Other Identifiers

1

Identifier Type: -

Identifier Source: org_study_id