Carfilzomib in Treating Patients With Chronic Graft-Versus-Host Disease

NCT ID: NCT02491359

Last Updated: 2019-02-06

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE2
• Total Enrollment: 20 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2015-11-12
• Study Completion Date: 2018-09-12

Brief Summary

This pilot phase II trial studies how well carfilzomib works in treating patients with chronic graft-versus-host disease. Chronic graft-versus-host disease is a complication of a donor bone marrow or blood cell transplant, usually occurring more than three months after transplant, in which donor cells damage the host tissue. Carfilzomib may be an effective treatment for chronic graft-versus-host disease.

Detailed Description

PRIMARY OBJECTIVE:

I. Determine proportion of subjects with treatment failure by 6 months of carfilzomib therapy for chronic graft-versus-host disease (GVHD).

SECONDARY OBJECTIVES:

I. Determine 3 month overall (complete + partial), and complete response rate.

II. Determine 6 month overall (complete + partial), and complete response rate.

III. Report overall survival, non-relapse mortality, primary malignancy relapse, failure-free survival, treatment success, and discontinuation of immune suppression at 6 months and 1 year.

IV. Examine functional outcome (2-minute walk test) and patient-reported outcomes (Lee Chronic GVHD Symptom Scale, quality of life [Short Form Health Survey (SF)-36, Functional Assessment of Cancer Therapy Bone Marrow Transplant (FACT-BMT) Questionnaire], Human Activity Profile [HAP]) at study enrollment, 6 months, and 1 year.

V. Study biologic effects of proteasome inhibition.

OUTLINE:

Patients receive carfilzomib intravenously (IV) over approximately 30 minutes on days 1, 8, and 15. Treatment repeats every 28 days for 6 courses in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up at 3, 6, and 12 months.

Conditions

Chronic Graft Versus Host Disease

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Treatment (carfilzomib)

Patients receive carfilzomib IV over approximately 30 minutes on days 1, 8, and 15. Treatment repeats every 28 days for 6 courses in the absence of disease progression or unacceptable toxicity.

Group Type: EXPERIMENTAL

Carfilzomib

Intervention Type: DRUG

Given IV

Laboratory Biomarker Analysis

Intervention Type: OTHER

Correlative studies

Quality-of-Life Assessment

Intervention Type: OTHER

Ancillary studies

Questionnaire Administration

Intervention Type: OTHER

Ancillary studies

Interventions

Carfilzomib

Given IV

Intervention Type: DRUG

Laboratory Biomarker Analysis

Correlative studies

Intervention Type: OTHER

Quality-of-Life Assessment

Ancillary studies

Intervention Type: OTHER

Questionnaire Administration

Ancillary studies

Intervention Type: OTHER

Other Intervention Names

Kyprolis; PR-171; Quality of Life Assessment

Eligibility Criteria

Inclusion Criteria

• Diagnosis of chronic GVHD according to National Institutes of Health (NIH) Consensus Criteria

• May have either classic chronic GVHD or overlap subtype of chronic GVHD
• Failure of at least one prior line of systemic immune suppressive therapy for management of chronic GVHD
• Subject underwent transplantation at least 3 months prior to enrollment
• Anticipated life expectancy >= 6 months
• Alanine aminotransferase (ALT) =< 3.5 times the upper limit of normal, unless due to chronic GVHD
• Bilirubin =< 2 mg/dL, unless due to chronic GVHD
• Absolute neutrophil count (ANC) >= 1.0 × 10^9/L
• Hemoglobin >= 8 g/dL
• Platelet count >= 50 × 10^9/L
• Creatinine clearance (CrCl) >= 15 mL/minute, either measured or calculated
• Signed informed consent in accordance with federal, local, and institutional guidelines
• Females of childbearing potential (FCBP) must agree to a pregnancy test at study enrollment and to practice contraception during the study
• Male subjects must agree to practice contraception during the study

Exclusion Criteria

• Evidence of recurrent or progressive underlying malignant disease
• Pregnant or lactating females
• Surgery within 21 days prior to enrollment

• Does not include placement of venous access device, bone marrow biopsy, GVHD diagnostic biopsy, or other routine procedures in chronic GVHD or post-transplantation care
• Uncontrolled infection within 14 days prior to enrollment

• Infection treated with appropriate antimicrobial therapy and without signs of progression/treatment failure does not constitute an exclusion criterion
• Documented human immunodeficiency virus (HIV) infection
• Active hepatitis B or C infection
• Documented unstable angina or myocardial infarction within 6 months prior to enrollment, New York Heart Association (NYHA) class III or IV heart failure, uncontrolled angina, severe uncontrolled ventricular arrhythmias, sick sinus syndrome, or electrocardiographic evidence of acute ischemia or grade 3 conduction system abnormalities (unless subject has a pacemaker), left ventricular ejection fraction (LVEF) < 40%, history of torsade de pointe
• Uncontrolled hypertension or uncontrolled diabetes within 14 days prior to enrollment

• Sustained systolic blood pressure > 160 or diastolic blood pressure > 100 despite medical therapy; sustained blood sugar > 300 despite medical therapy
• Chronic hypertension or diabetes on appropriate medical therapy does not constitute an exclusion criterion
• Non-hematologic malignancy within the past 3 years with the exception of:

• Adequately treated basal cell carcinoma, squamous cell skin cancer, or thyroid cancer
• Carcinoma in situ of the cervix or breast
• Prostate cancer of Gleason grade 6 or less with stable prostate-specific antigen levels
• Cancer considered cured by surgical resection or unlikely to impact survival during the duration of the study
• Significant neuropathy per Common Terminology Criteria for Adverse Events (CTCAE) version (ver.) 4.03 or current version (grade 3 and above, or grade 2 with pain) within 14 days prior to enrollment
• History of allergy to Captisol (a cyclodextrin derivative used to solubilize carfilzomib)
• Contraindication to all available herpes simplex virus (HSV)/varicella prophylactic antiviral drugs
• Pleural effusions requiring thoracentesis, or ascites requiring paracentesis, within 14 days prior to enrollment
• Any other clinically significant medical or psychological disease or condition that, in the investigator's opinion, may interfere with protocol adherence or a subject's ability to give informed consent
• New systemic immune suppressive agent added for the treatment of chronic GVHD within 2 weeks prior to enrollment
• Treatment with a non-Food and Drug Administration (FDA) approved drug in the previous 4 weeks

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

National Cancer Institute (NCI)

NIH

Sponsor Role: collaborator

Fred Hutchinson Cancer Center

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Stephanie Lee

Role: PRINCIPAL_INVESTIGATOR

Fred Hutch/University of Washington Cancer Consortium

Locations

Moffitt Cancer Center

Tampa, Florida, United States

Roswell Park Cancer Institute

Buffalo, New York, United States

Ohio State University Comprehensive Cancer Center

Columbus, Ohio, United States

University of Pittsburgh Cancer Institute (UPCI)

Pittsburgh, Pennsylvania, United States

Fred Hutch/University of Washington Cancer Consortium

Seattle, Washington, United States

Countries

United States

Provided Documents

Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

NCI-2015-00809

Identifier Type: REGISTRY

Identifier Source: secondary_id

9228.00

Identifier Type: -

Identifier Source: secondary_id

9228

Identifier Type: OTHER

Identifier Source: secondary_id

P30CA015704

Identifier Type: NIH

Identifier Source: secondary_id

View Link

9228

Identifier Type: -

Identifier Source: org_study_id