Real Evidence of Anticoagulation Treatment in Non-valvular Atrial Fibrillation in Germany, UK and France: REACT-AF2

NCT ID: NCT02488421

Last Updated: 2016-12-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

38122 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-06-30

Study Completion Date

2016-07-31

Brief Summary

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The purpose of this study is to determine and compare the persistence rate of newly prescribed apixaban, rivaroxaban, dabigatran and VKAs in patients with NVAF.

Detailed Description

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Actual number of patients enrolled for UK : 15242 patients

Actual number of patients enrolled for Germany : 22880 patients

Conditions

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Non-valvular Atrial Fibrillation

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Patient treated with Apixaban

No interventions assigned to this group

Patient treated with Rivaroxaban

No interventions assigned to this group

Patient treated with Dabigatran

No interventions assigned to this group

Patient treated with vitamin K antagonists

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Have an apixaban, rivaroxaban, dabigatran or VKA prescription during the study period
* Are ≥18 years old at index date
* Have ≥12 months of computerised medical data prior to index date
* Have a record of AF on or ever prior to index date (index OAC prescription)

Exclusion Criteria

* Have a record for a valvular condition (ie, rheumatic valvular disease and prosthetic valves) on or ever prior to index date
* Have a history (ever prior to index date) of the Oral anticoagulant (OACs) which are prescribed during the study period
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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IMS Health

OTHER

Sponsor Role collaborator

OXON Epidemiology

INDUSTRY

Sponsor Role collaborator

Bristol-Myers Squibb

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Bristol-Myers Squibb

Role: STUDY_DIRECTOR

Bristol-Myers Squibb

References

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Collings SL, Vannier-Moreau V, Johnson ME, Stynes G, Lefevre C, Maguire A, Asmar J, Bizouard G, Duhot D, Mouquet F, Fauchier L. Initiation and continuation of oral anticoagulant prescriptions for stroke prevention in non-valvular atrial fibrillation: A cohort study in primary care in France. Arch Cardiovasc Dis. 2018 May;111(5):370-379. doi: 10.1016/j.acvd.2017.10.003. Epub 2018 Feb 3.

Reference Type DERIVED
PMID: 29398546 (View on PubMed)

Johnson ME, Lefevre C, Collings SL, Evans D, Kloss S, Ridha E, Maguire A. Early real-world evidence of persistence on oral anticoagulants for stroke prevention in non-valvular atrial fibrillation: a cohort study in UK primary care. BMJ Open. 2016 Sep 26;6(9):e011471. doi: 10.1136/bmjopen-2016-011471.

Reference Type DERIVED
PMID: 27678530 (View on PubMed)

Related Links

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Other Identifiers

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CV185-371

Identifier Type: -

Identifier Source: org_study_id