Trial Outcomes & Findings for Individual Differences in the Response to Drugs (NCT NCT02485158)

NCT ID: NCT02485158

Last Updated: 2016-11-29

Results Overview

Drug effects will be measured using the Drug Effects Questionnaire (Fischman \& Foltin, 1991). The DEQ included 5 subscales; feeling, liking, and disliking the drug effect, feeling high, and wanting more of the drug. Each subscale ranged from 1(Not at all) to 100(Very much). The change in DFQ was assessed by the difference in measurements between baseline and 30 minutes after capsule administration and before drink administration. Baseline was measure 15 minutes prior to capsule administration.

• Recruitment status: COMPLETED
• Study phase: NA
• Target enrollment: 28 participants
• Primary outcome timeframe: Measured 15 minutes prior to capsule administration and 30 minutes after capsule administration and before drink administration
• Results posted on: 2016-11-29

Participant Flow

Healthy social drinkers were recruited from the Chicago area through flyers and online advertisements, from June 2013 through February 2014.

Participant milestones

Measure	Healthy Adult Volunteers 24 healthy adult volunteers completed a 6 session within-subject, double-blind, placebo-controlled trial. At three of these sessions, they received one of three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. At each session, they received a capsule and a drink. At the amphetamine drug session, they received a capsule containing d-amphetamine and a placebo beverage. At the THC drug session, they received a capsule containing THC and a placebo beverage. At the alcohol drug session they received a placebo capsule and a beverage containing alcohol. At the three matched placebo sessions, both the capsule and the beverage were placebo.
Overall Study STARTED	28
Overall Study COMPLETED	24
Overall Study NOT COMPLETED	4

Reasons for withdrawal

Measure	Healthy Adult Volunteers 24 healthy adult volunteers completed a 6 session within-subject, double-blind, placebo-controlled trial. At three of these sessions, they received one of three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. At each session, they received a capsule and a drink. At the amphetamine drug session, they received a capsule containing d-amphetamine and a placebo beverage. At the THC drug session, they received a capsule containing THC and a placebo beverage. At the alcohol drug session they received a placebo capsule and a beverage containing alcohol. At the three matched placebo sessions, both the capsule and the beverage were placebo.
Overall Study Withdrawal by Subject	3
Overall Study expected drug side effect	1

Baseline Characteristics

Individual Differences in the Response to Drugs

Baseline characteristics by cohort

Measure	Healthy Adult Volunteers n=28 Participants All healthy adult volunteers completed a 6 session within-subject, double-blind, placebo-controlled trial. At three of these sessions, they received one of three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. At each session, they received a capsule and a drink. At the amphetamine drug session, they received a capsule containing d-amphetamine and a placebo beverage. At the THC drug session, they received a capsule containing THC and a placebo beverage. At the alcohol drug session they received a placebo capsule and a beverage containing alcohol. At the three matched placebo sessions, both the capsule and the beverage were placebo.
Age, Continuous	24.6 years STANDARD_DEVIATION 2.8 • n=5 Participants
Sex: Female, Male Female	16 Participants n=5 Participants
Sex: Female, Male Male	12 Participants n=5 Participants

PRIMARY outcome

Timeframe: Measured 15 minutes prior to capsule administration and 30 minutes after capsule administration and before drink administration

Population: Participants who completed all sessions

Drug effects will be measured using the Drug Effects Questionnaire (Fischman & Foltin, 1991). The DEQ included 5 subscales; feeling, liking, and disliking the drug effect, feeling high, and wanting more of the drug. Each subscale ranged from 1(Not at all) to 100(Very much). The change in DFQ was assessed by the difference in measurements between baseline and 30 minutes after capsule administration and before drink administration. Baseline was measure 15 minutes prior to capsule administration.

Outcome measures

Measure	AMP Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. AMP arm represents a amphetamine drug session in which participants received a capsule containing d-amphetamine.	ALC Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. ALC arm represents a session in which participants received alcohol beverage.	THC Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. At the THC drug session, they received a capsule containing THC.	AMP Placebo Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. AMP placebo arm represents a session in which participants received a placebo drug.	ALC Placebo Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. ALC placebo arm represents a session in which participants received a placebo beverage.	THC Placebo Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. THC placebo arm represents a session in which participants received a placebo drug.
Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Capsule Administration DEQ Feel	4.79 units on a scale Standard Deviation 7.22	12.83 units on a scale Standard Deviation 18.78	11.08 units on a scale Standard Deviation 21.09	12.17 units on a scale Standard Deviation 19.90	9.38 units on a scale Standard Deviation 11.12	4.5 units on a scale Standard Deviation 13.16
Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Capsule Administration DEQ Like	16.08 units on a scale Standard Deviation 27.47	18.67 units on a scale Standard Deviation 28.81	11.75 units on a scale Standard Deviation 21.84	9.0 units on a scale Standard Deviation 18.42	10.04 units on a scale Standard Deviation 17.90	9.67 units on a scale Standard Deviation 24.14
Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Capsule Administration DEQ Dislike	4.21 units on a scale Standard Deviation 9.43	11.71 units on a scale Standard Deviation 20.35	12.38 units on a scale Standard Deviation 23.77	10.71 units on a scale Standard Deviation 18.75	11.0 units on a scale Standard Deviation 20.60	0.83 units on a scale Standard Deviation 2.24
Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Capsule Administration DEQ High	3.29 units on a scale Standard Deviation 6.06	8.83 units on a scale Standard Deviation 16.31	10.58 units on a scale Standard Deviation 21.85	6.96 units on a scale Standard Deviation 18.44	5.5 units on a scale Standard Deviation 10.43	3.67 units on a scale Standard Deviation 9.40
Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Capsule Administration DEQ More	14.21 units on a scale Standard Deviation 25.26	13.5 units on a scale Standard Deviation 25.24	6.54 units on a scale Standard Deviation 13.71	5.63 units on a scale Standard Deviation 12.59	3.71 units on a scale Standard Deviation 7.66	11.0 units on a scale Standard Deviation 25.32

PRIMARY outcome

Timeframe: Measured 15 minutes prior to capsule administration and 30 minutes after drink administration.

Population: Participants who completed all sessions

Drug effects will be measured using the Drug Effects Questionnaire (Fischman & Foltin, 1991). The DEQ included 5 subscales; feeling, liking, and disliking the drug effect, feeling high, and wanting more of the drug. Each subscale ranged from 1(Not at all) to 100(Very much). The change in DFQ was assessed by the difference in measurements between baseline and 30 minutes after drink administration. Baseline was measure 15 minutes prior to capsule administration.

Outcome measures

Measure	AMP Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. AMP arm represents a amphetamine drug session in which participants received a capsule containing d-amphetamine.	ALC Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. ALC arm represents a session in which participants received alcohol beverage.	THC Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. At the THC drug session, they received a capsule containing THC.	AMP Placebo Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. AMP placebo arm represents a session in which participants received a placebo drug.	ALC Placebo Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. ALC placebo arm represents a session in which participants received a placebo beverage.	THC Placebo Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. THC placebo arm represents a session in which participants received a placebo drug.
Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Drink Administration DEQ Feel	43.42 units on a scale Standard Deviation 29.53	76.83 units on a scale Standard Deviation 20.01	38.25 units on a scale Standard Deviation 33.45	21.58 units on a scale Standard Deviation 19.52	17.83 units on a scale Standard Deviation 22.56	18.63 units on a scale Standard Deviation 20.69
Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Drink Administration DEQ Like	53.88 units on a scale Standard Deviation 34.49	45.08 units on a scale Standard Deviation 28.43	28.75 units on a scale Standard Deviation 30.05	16.63 units on a scale Standard Deviation 22.89	14.38 units on a scale Standard Deviation 20.78	25.29 units on a scale Standard Deviation 28.76
Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Drink Administration DEQ Dislike	15.71 units on a scale Standard Deviation 22.76	43.96 units on a scale Standard Deviation 28.96	25.63 units on a scale Standard Deviation 35.03	17.71 units on a scale Standard Deviation 23.32	16.68 units on a scale Standard Deviation 26.83	15.79 units on a scale Standard Deviation 20.66
Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Drink Administration DEQ High	30.5 units on a scale Standard Deviation 27.78	50.38 units on a scale Standard Deviation 32.15	31.75 units on a scale Standard Deviation 35.00	12.54 units on a scale Standard Deviation 18.09	11.5 units on a scale Standard Deviation 21.80	12.96 units on a scale Standard Deviation 20.22
Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Drink Administration DEQ More	42.17 units on a scale Standard Deviation 35.27	24.75 units on a scale Standard Deviation 32.67	17.46 units on a scale Standard Deviation 25.18	10.96 units on a scale Standard Deviation 19.14	10.0 units on a scale Standard Deviation 18.32	18.96 units on a scale Standard Deviation 28.97

PRIMARY outcome

Timeframe: Measured 15 minutes prior to capsule administration and 90 minutes after drink administration.

Population: Participants who completed all sessions

Drug effects will be measured using the Drug Effects Questionnaire (Fischman & Foltin, 1991). The DEQ included 5 subscales; feeling, liking, and disliking the drug effect, feeling high, and wanting more of the drug. Each subscale ranged from 1(Not at all) to 100(Very much). The change in DFQ was assessed by the difference in measurements between baseline and 90 minutes after drink administration. Baseline was measure 15 minutes prior to capsule administration.

Outcome measures

Measure	AMP Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. AMP arm represents a amphetamine drug session in which participants received a capsule containing d-amphetamine.	ALC Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. ALC arm represents a session in which participants received alcohol beverage.	THC Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. At the THC drug session, they received a capsule containing THC.	AMP Placebo Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. AMP placebo arm represents a session in which participants received a placebo drug.	ALC Placebo Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. ALC placebo arm represents a session in which participants received a placebo beverage.	THC Placebo Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. THC placebo arm represents a session in which participants received a placebo drug.
Change in General Drug Effects (Drug Effects Questionnaire) at 90 Minutes After Drink Administration DEQ Feel	34.92 units on a scale Standard Deviation 24.75	61.21 units on a scale Standard Deviation 24.02	31.54 units on a scale Standard Deviation 31.41	16.46 units on a scale Standard Deviation 18.97	12.75 units on a scale Standard Deviation 18.74	13.17 units on a scale Standard Deviation 19.05
Change in General Drug Effects (Drug Effects Questionnaire) at 90 Minutes After Drink Administration DEQ Like	55.67 units on a scale Standard Deviation 31.45	29.92 units on a scale Standard Deviation 28.57	20.08 units on a scale Standard Deviation 26.32	10.42 units on a scale Standard Deviation 18.22	11.38 units on a scale Standard Deviation 19.35	13.25 units on a scale Standard Deviation 22.87
Change in General Drug Effects (Drug Effects Questionnaire) at 90 Minutes After Drink Administration DEQ Dislike	16.54 units on a scale Standard Deviation 21.60	50.46 units on a scale Standard Deviation 26.47	23.25 units on a scale Standard Deviation 29.72	17.54 units on a scale Standard Deviation 26.16	15.33 units on a scale Standard Deviation 24.85	15.96 units on a scale Standard Deviation 24.91
Change in General Drug Effects (Drug Effects Questionnaire) at 90 Minutes After Drink Administration DEQ High	27.92 units on a scale Standard Deviation 24.57	41.83 units on a scale Standard Deviation 30.74	29.21 units on a scale Standard Deviation 32.78	6.83 units on a scale Standard Deviation 12.47	7.25 units on a scale Standard Deviation 13.50	7.58 units on a scale Standard Deviation 12.65
Change in General Drug Effects (Drug Effects Questionnaire) at 90 Minutes After Drink Administration DEQ More	50.21 units on a scale Standard Deviation 36.06	25.88 units on a scale Standard Deviation 35.11	16.54 units on a scale Standard Deviation 23.69	6.54 units on a scale Standard Deviation 15.33	7.71 units on a scale Standard Deviation 16.59	12.88 units on a scale Standard Deviation 21.88

PRIMARY outcome

Timeframe: Measured 15 minutes prior to capsule administration and 120 minutes after drink administration.

Population: Participants who completed all sessions

Drug effects will be measured using the Drug Effects Questionnaire (Fischman & Foltin, 1991). The DEQ included 5 subscales; feeling, liking, and disliking the drug effect, feeling high, and wanting more of the drug. Each subscale ranged from 1(Not at all) to 100(Very much). The change in DFQ was assessed by the difference in measurements between baseline and 120 minutes after drink administration. Baseline was measure 15 minutes prior to capsule administration.

Outcome measures

Measure	AMP Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. AMP arm represents a amphetamine drug session in which participants received a capsule containing d-amphetamine.	ALC Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. ALC arm represents a session in which participants received alcohol beverage.	THC Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. At the THC drug session, they received a capsule containing THC.	AMP Placebo Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. AMP placebo arm represents a session in which participants received a placebo drug.	ALC Placebo Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. ALC placebo arm represents a session in which participants received a placebo beverage.	THC Placebo Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. THC placebo arm represents a session in which participants received a placebo drug.
Change in General Drug Effects (Drug Effects Questionnaire) at 120 Minutes After Drink Administraion DEQ More	45.38 units on a scale Standard Deviation 34.86	17.5 units on a scale Standard Deviation 27.95	9.92 units on a scale Standard Deviation 18.06	3.13 units on a scale Standard Deviation 5.53	6.54 units on a scale Standard Deviation 15.59	9.88 units on a scale Standard Deviation 19.63
Change in General Drug Effects (Drug Effects Questionnaire) at 120 Minutes After Drink Administraion DEQ Feel	27.08 units on a scale Standard Deviation 22.38	43.92 units on a scale Standard Deviation 24.18	24.08 units on a scale Standard Deviation 29.28	11.92 units on a scale Standard Deviation 14.26	7.96 units on a scale Standard Deviation 14.08	7.88 units on a scale Standard Deviation 14.65
Change in General Drug Effects (Drug Effects Questionnaire) at 120 Minutes After Drink Administraion DEQ Like	43.75 units on a scale Standard Deviation 36.08	23.79 units on a scale Standard Deviation 25.61	18 units on a scale Standard Deviation 27.26	7.04 units on a scale Standard Deviation 13.90	4.83 units on a scale Standard Deviation 11.49	8.67 units on a scale Standard Deviation 16.86
Change in General Drug Effects (Drug Effects Questionnaire) at 120 Minutes After Drink Administraion DEQ Dislike	11.92 units on a scale Standard Deviation 19.56	44.92 units on a scale Standard Deviation 31.37	19.63 units on a scale Standard Deviation 27.21	13.38 units on a scale Standard Deviation 22.39	11.08 units on a scale Standard Deviation 23.89	8.88 units on a scale Standard Deviation 18.69
Change in General Drug Effects (Drug Effects Questionnaire) at 120 Minutes After Drink Administraion DEQ High	18.88 units on a scale Standard Deviation 21.43	29.38 units on a scale Standard Deviation 25.77	21.96 units on a scale Standard Deviation 30.06	5.04 units on a scale Standard Deviation 8.12	5.08 units on a scale Standard Deviation 11.20	4.83 units on a scale Standard Deviation 10.45

PRIMARY outcome

Timeframe: Measured 15 minutes prior to capsule administration and 150 minutes after drink administration.

Population: Participants who completed all sessions

Drug effects will be measured using the Drug Effects Questionnaire (Fischman & Foltin, 1991). The DEQ included 5 subscales; feeling, liking, and disliking the drug effect, feeling high, and wanting more of the drug. Each subscale ranged from 1(Not at all) to 100(Very much). The change in DFQ was assessed by the difference in measurements between baseline and 150 minutes after drink administration. Baseline was measure 15 minutes prior to capsule administration.

Outcome measures

Measure	AMP Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. AMP arm represents a amphetamine drug session in which participants received a capsule containing d-amphetamine.	ALC Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. ALC arm represents a session in which participants received alcohol beverage.	THC Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. At the THC drug session, they received a capsule containing THC.	AMP Placebo Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. AMP placebo arm represents a session in which participants received a placebo drug.	ALC Placebo Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. ALC placebo arm represents a session in which participants received a placebo beverage.	THC Placebo Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. THC placebo arm represents a session in which participants received a placebo drug.
Change in General Drug Effects (Drug Effects Questionnaire) at 150 Minutes After Drink Administration DEQ Feel	19.79 units on a scale Standard Deviation 17.72	30.83 units on a scale Standard Deviation 22.52	18.63 units on a scale Standard Deviation 25.28	5.83 units on a scale Standard Deviation 10.72	4.63 units on a scale Standard Deviation 10.48	4.63 units on a scale Standard Deviation 7.80
Change in General Drug Effects (Drug Effects Questionnaire) at 150 Minutes After Drink Administration DEQ Like	39.5 units on a scale Standard Deviation 34.58	21.33 units on a scale Standard Deviation 24.74	11.71 units on a scale Standard Deviation 19.22	6.74 units on a scale Standard Deviation 14.88	2.42 units on a scale Standard Deviation 6.76	4.96 units on a scale Standard Deviation 14.48
Change in General Drug Effects (Drug Effects Questionnaire) at 150 Minutes After Drink Administration DEQ Dislike	11.25 units on a scale Standard Deviation 20.64	40.75 units on a scale Standard Deviation 32.31	17.79 units on a scale Standard Deviation 26.78	8.09 units on a scale Standard Deviation 21.80	4.29 units on a scale Standard Deviation 13.84	6.42 units on a scale Standard Deviation 15.69
Change in General Drug Effects (Drug Effects Questionnaire) at 150 Minutes After Drink Administration DEQ High	16.33 units on a scale Standard Deviation 18.68	20.46 units on a scale Standard Deviation 23.70	14.75 units on a scale Standard Deviation 20.27	2.87 units on a scale Standard Deviation 4.48	2.13 units on a scale Standard Deviation 4.83	1.96 units on a scale Standard Deviation 4.56
Change in General Drug Effects (Drug Effects Questionnaire) at 150 Minutes After Drink Administration DEQ More	44.08 units on a scale Standard Deviation 34.63	12.58 units on a scale Standard Deviation 24.39	9.38 units on a scale Standard Deviation 18.95	2.87 units on a scale Standard Deviation 10.55	5.04 units on a scale Standard Deviation 12.75	6.21 units on a scale Standard Deviation 15.19

PRIMARY outcome

Timeframe: Measured 15 minutes prior to capsule administration and 180 minutes after drink administration.

Population: Participants who completed all sessions

Drug effects will be measured using the Drug Effects Questionnaire (Fischman & Foltin, 1991). The DEQ included 5 subscales; feeling, liking, and disliking the drug effect, feeling high, and wanting more of the drug. Each subscale ranged from 1(Not at all) to 100(Very much). The change in DFQ was assessed by the difference in measurements between baseline and 180 minutes after drink administration. Baseline was measure 15 minutes prior to capsule administration.

Outcome measures

Measure	AMP Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. AMP arm represents a amphetamine drug session in which participants received a capsule containing d-amphetamine.	ALC Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. ALC arm represents a session in which participants received alcohol beverage.	THC Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. At the THC drug session, they received a capsule containing THC.	AMP Placebo Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. AMP placebo arm represents a session in which participants received a placebo drug.	ALC Placebo Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. ALC placebo arm represents a session in which participants received a placebo beverage.	THC Placebo Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. THC placebo arm represents a session in which participants received a placebo drug.
Change in General Drug Effects (Drug Effects Questionnaire) at 180 Minutes After Drink Administration DEQ Feel	16.13 units on a scale Standard Deviation 17.06	22.21 units on a scale Standard Deviation 19.71	15.67 units on a scale Standard Deviation 24.63	3.5 units on a scale Standard Deviation 8.548	2.08 units on a scale Standard Deviation 5.01	2.54 units on a scale Standard Deviation 4.59
Change in General Drug Effects (Drug Effects Questionnaire) at 180 Minutes After Drink Administration DEQ Like	31.08 units on a scale Standard Deviation 34.86	9.04 units on a scale Standard Deviation 14.29	7.33 units on a scale Standard Deviation 15.82	2.54 units on a scale Standard Deviation 11.23	1.75 units on a scale Standard Deviation 7.56	4.0 units on a scale Standard Deviation 12.47
Change in General Drug Effects (Drug Effects Questionnaire) at 180 Minutes After Drink Administration DEQ Dislike	11.54 units on a scale Standard Deviation 25.17	29.5 units on a scale Standard Deviation 34.28	16.13 units on a scale Standard Deviation 28.42	4.25 units on a scale Standard Deviation 17.24	4.29 units on a scale Standard Deviation 16.80	4.63 units on a scale Standard Deviation 13.65
Change in General Drug Effects (Drug Effects Questionnaire) at 180 Minutes After Drink Administration DEQ High	11.67 units on a scale Standard Deviation 15.29	14.13 units on a scale Standard Deviation 19.36	11.79 units on a scale Standard Deviation 18.36	1.63 units on a scale Standard Deviation 4.92	1.25 units on a scale Standard Deviation 3.30	1.04 units on a scale Standard Deviation 3.30
Change in General Drug Effects (Drug Effects Questionnaire) at 180 Minutes After Drink Administration DEQ More	38.38 units on a scale Standard Deviation 34.54	7.0 units on a scale Standard Deviation 19.77	10.04 units on a scale Standard Deviation 18.61	2.46 units on a scale Standard Deviation 10.99	4.04 units on a scale Standard Deviation 12.22	5.04 units on a scale Standard Deviation 12.89

PRIMARY outcome

Timeframe: Measured 15 minutes prior to capsule administration and 210 minutes after drink administration.

Population: Participants who completed all sessions

Drug effects will be measured using the Drug Effects Questionnaire (Fischman & Foltin, 1991). The DEQ included 5 subscales; feeling, liking, and disliking the drug effect, feeling high, and wanting more of the drug. Each subscale ranged from 1(Not at all) to 100(Very much). The change in DFQ was assessed by the difference in measurements between baseline and 210 minutes after drink administration. Baseline was measure 15 minutes prior to capsule administration.

Outcome measures

Measure	AMP Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. AMP arm represents a amphetamine drug session in which participants received a capsule containing d-amphetamine.	ALC Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. ALC arm represents a session in which participants received alcohol beverage.	THC Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. At the THC drug session, they received a capsule containing THC.	AMP Placebo Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. AMP placebo arm represents a session in which participants received a placebo drug.	ALC Placebo Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. ALC placebo arm represents a session in which participants received a placebo beverage.	THC Placebo Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. THC placebo arm represents a session in which participants received a placebo drug.
Change in General Drug Effects (Drug Effects Questionnaire) at 210 Minutes After Drink Administration DEQ Feel	11.08 units on a scale Standard Deviation 16.71	12.88 units on a scale Standard Deviation 15.88	5.79 units on a scale Standard Deviation 10.91	2.17 units on a scale Standard Deviation 5.74	0.96 units on a scale Standard Deviation 2.74	1.08 units on a scale Standard Deviation 2.75
Change in General Drug Effects (Drug Effects Questionnaire) at 210 Minutes After Drink Administration DEQ Like	18.38 units on a scale Standard Deviation 31.38	7.33 units on a scale Standard Deviation 14.62	4.88 units on a scale Standard Deviation 10.41	1.96 units on a scale Standard Deviation 7.04	0.25 units on a scale Standard Deviation 0.74	4.38 units on a scale Standard Deviation 13.73
Change in General Drug Effects (Drug Effects Questionnaire) at 210 Minutes After Drink Administration DEQ High	6.25 units on a scale Standard Deviation 9.88	9.21 units on a scale Standard Deviation 15.84	4.96 units on a scale Standard Deviation 11.02	0.33 units on a scale Standard Deviation 1.05	0.83 units on a scale Standard Deviation 1.76	0.42 units on a scale Standard Deviation 1.32
Change in General Drug Effects (Drug Effects Questionnaire) at 210 Minutes After Drink Administration DEQ More	32.5 units on a scale Standard Deviation 31.84	4.54 units on a scale Standard Deviation 17.72	8.79 units on a scale Standard Deviation 17.04	2.25 units on a scale Standard Deviation 8.19	3.83 units on a scale Standard Deviation 12.09	6.17 units on a scale Standard Deviation 14.65
Change in General Drug Effects (Drug Effects Questionnaire) at 210 Minutes After Drink Administration DEQ Dislike	8.54 units on a scale Standard Deviation 24.16	22.71 units on a scale Standard Deviation 30.79	6.83 units on a scale Standard Deviation 15.46	7.46 units on a scale Standard Deviation 23.16	1.29 units on a scale Standard Deviation 3.82	4.54 units on a scale Standard Deviation 15.14

PRIMARY outcome

Timeframe: Measured 15 minutes prior to capsule administration and 30 minutes after capsule administration and before drink administration

Population: Participants who completed all sessions

Specific drug effects will be measured using the Addiction Research Center Inventory (Martin et al. 1971). The ARCI measures effects specific to drug classes, including the effects of AMP-like drugs (A scale, 0 to 11), morphine and benzedrine like drugs (MBG scale, 0 to 14), lysergic acid-like drugs (LSD scale, 0 to 14), benzedrine-like drugs (BG scale, 0 to 13), pentobarbital-chlorpromazine and ALC-like drugs (PCAG scale, 0 to 15), and cannabis-like drugs (M scale, 0 to 12). We used this questionnaire as a manipulation check to ensure that the drugs produced their typical drug-specific effects in this study. For example, zero value of A sacle would be minimum report of amphetamine-like drug effects, and 11 would be maximum report of amphetamine-like effects. The change in ARCI was assessed by the difference in measurements between baseline and 30 minutes after capsule administration and before drink administration. Baseline was measure 15 minutes prior to capsule administration.

Outcome measures

Measure	AMP Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. AMP arm represents a amphetamine drug session in which participants received a capsule containing d-amphetamine.	ALC Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. ALC arm represents a session in which participants received alcohol beverage.	THC Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. At the THC drug session, they received a capsule containing THC.	AMP Placebo Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. AMP placebo arm represents a session in which participants received a placebo drug.	ALC Placebo Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. ALC placebo arm represents a session in which participants received a placebo beverage.	THC Placebo Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. THC placebo arm represents a session in which participants received a placebo drug.
Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Capsule Administration ARC MBG	-0.58 units on a scale Standard Deviation 1.44	-0.29 units on a scale Standard Deviation 1.27	-0.71 units on a scale Standard Deviation 1.88	-0.58 units on a scale Standard Deviation 0.65	-0.67 units on a scale Standard Deviation 1.46	0.33 units on a scale Standard Deviation 1.37
Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Capsule Administration ARC M	0.08 units on a scale Standard Deviation 1.06	0.83 units on a scale Standard Deviation 1.81	0.42 units on a scale Standard Deviation 1.32	0.5 units on a scale Standard Deviation 1.25	0.33 units on a scale Standard Deviation 1.05	0.42 units on a scale Standard Deviation 1.18
Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Capsule Administration ARC A	-0.17 units on a scale Standard Deviation 0.92	0.25 units on a scale Standard Deviation 1.33	-0.04 units on a scale Standard Deviation 1.16	-0.25 units on a scale Standard Deviation 0.61	-0.17 units on a scale Standard Deviation 1.2	0.54 units on a scale Standard Deviation 0.88
Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Capsule Administration ARC LSD	0.13 units on a scale Standard Deviation 0.85	0.33 units on a scale Standard Deviation 0.82	0.38 units on a scale Standard Deviation 1.69	0.13 units on a scale Standard Deviation 0.99	0.08 units on a scale Standard Deviation 0.97	-0.17 units on a scale Standard Deviation 0.64
Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Capsule Administration ARC BG	-0.46 units on a scale Standard Deviation 1.02	-0.75 units on a scale Standard Deviation 1.67	-0.79 units on a scale Standard Deviation 2.0	-1.17 units on a scale Standard Deviation 1.52	-0.92 units on a scale Standard Deviation 1.21	0.25 units on a scale Standard Deviation 1.03
Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Capsule Administration ARC PCAG	0.58 units on a scale Standard Deviation 1.21	1.29 units on a scale Standard Deviation 2.39	2.92 units on a scale Standard Deviation 2.73	1.96 units on a scale Standard Deviation 2.44	0.92 units on a scale Standard Deviation 1.61	0.42 units on a scale Standard Deviation 1.02

PRIMARY outcome

Timeframe: Measured 15 minutes prior to capsule administration and 30 minutes after drink administration

Population: Participants who completed all sessions

Specific drug effects will be measured using the Addiction Research Center Inventory (Martin et al. 1971). The ARCI measures effects specific to drug classes, including the effects of AMP-like drugs (A scale, 0 to 11), morphine and benzedrine like drugs (MBG scale, 0 to 14), lysergic acid-like drugs (LSD scale, 0 to 14), benzedrine-like drugs (BG scale, 0 to 13), pentobarbital-chlorpromazine and ALC-like drugs (PCAG scale, 0 to 15), and cannabis-like drugs (M scale, 0 to 12). We used this questionnaire as a manipulation check to ensure that the drugs produced their typical drug-specific effects in this study. For example, zero value of A sacle would be minimum report of amphetamine-like drug effects, and 11 would be maximum report of amphetamine-like effects. The change in ARCI was assessed by the difference in measurements between baseline and 30 minutes after drink administration. Baseline was measure 15 minutes prior to capsule administration.

Outcome measures

Measure	AMP Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. AMP arm represents a amphetamine drug session in which participants received a capsule containing d-amphetamine.	ALC Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. ALC arm represents a session in which participants received alcohol beverage.	THC Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. At the THC drug session, they received a capsule containing THC.	AMP Placebo Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. AMP placebo arm represents a session in which participants received a placebo drug.	ALC Placebo Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. ALC placebo arm represents a session in which participants received a placebo beverage.	THC Placebo Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. THC placebo arm represents a session in which participants received a placebo drug.
Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Drink Administration ARC A	2.88 units on a scale Standard Deviation 2.80	1.92 units on a scale Standard Deviation 2.64	0.17 units on a scale Standard Deviation 0.96	0 units on a scale Standard Deviation 0.93	-0.33 units on a scale Standard Deviation 1.61	0.71 units on a scale Standard Deviation 1.40
Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Drink Administration ARC MBG	3.71 units on a scale Standard Deviation 4.59	1.38 units on a scale Standard Deviation 4.79	-0.54 units on a scale Standard Deviation 3.04	0 units on a scale Standard Deviation 1.77	-1.17 units on a scale Standard Deviation 2.75	0.88 units on a scale Standard Deviation 3.26
Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Drink Administration ARC PCAG	-1 units on a scale Standard Deviation 1.89	3.71 units on a scale Standard Deviation 4.29	2.96 units on a scale Standard Deviation 3.33	2.25 units on a scale Standard Deviation 3.55	1.54 units on a scale Standard Deviation 3.24	1.13 units on a scale Standard Deviation 2.35
Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Drink Administration ARC M	3.21 units on a scale Standard Deviation 2.73	3.42 units on a scale Standard Deviation 2.22	2.04 units on a scale Standard Deviation 2.56	0.42 units on a scale Standard Deviation 0.93	0.29 units on a scale Standard Deviation 1.16	0.96 units on a scale Standard Deviation 1.78
Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Drink Administration ARC LSD	1.13 units on a scale Standard Deviation 2.03	2.63 units on a scale Standard Deviation 2.32	1.54 units on a scale Standard Deviation 2.47	0.33 units on a scale Standard Deviation 1.09	0.29 units on a scale Standard Deviation 1.12	0.13 units on a scale Standard Deviation 1.23
Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Drink Administration ARC BG	1.63 units on a scale Standard Deviation 2.28	-0.88 units on a scale Standard Deviation 3.00	-1.38 units on a scale Standard Deviation 1.64	-0.83 units on a scale Standard Deviation 1.31	-0.96 units on a scale Standard Deviation 1.99	0.04 units on a scale Standard Deviation 1.46

PRIMARY outcome

Timeframe: Measured 15 minutes prior to capsule administration and 90 minutes after drink administration

Population: Participants who completed all sessions

Specific drug effects will be measured using the Addiction Research Center Inventory (Martin et al. 1971). The ARCI measures effects specific to drug classes, including the effects of AMP-like drugs (A scale, 0 to 11), morphine and benzedrine like drugs (MBG scale, 0 to 14), lysergic acid-like drugs (LSD scale, 0 to 14), benzedrine-like drugs (BG scale, 0 to 13), pentobarbital-chlorpromazine and ALC-like drugs (PCAG scale, 0 to 15), and cannabis-like drugs (M scale, 0 to 12). We used this questionnaire as a manipulation check to ensure that the drugs produced their typical drug-specific effects in this study. For example, zero value of A sacle would be minimum report of amphetamine-like drug effects, and 11 would be maximum report of amphetamine-like effects. The change in ARCI was assessed by the difference in measurements between baseline and 90 minutes after drink administration. Baseline was measure 15 minutes prior to capsule administration.

Outcome measures

Measure	AMP Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. AMP arm represents a amphetamine drug session in which participants received a capsule containing d-amphetamine.	ALC Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. ALC arm represents a session in which participants received alcohol beverage.	THC Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. At the THC drug session, they received a capsule containing THC.	AMP Placebo Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. AMP placebo arm represents a session in which participants received a placebo drug.	ALC Placebo Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. ALC placebo arm represents a session in which participants received a placebo beverage.	THC Placebo Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. THC placebo arm represents a session in which participants received a placebo drug.
Change in Specific Drug Effects (Addiction Research Center Inventory) at 90 Minutes After Drink Administration ARC A	2.96 units on a scale Standard Deviation 2.49	0.29 units on a scale Standard Deviation 2.44	0 units on a scale Standard Deviation 1.22	-0.33 units on a scale Standard Deviation 0.76	-0.58 units on a scale Standard Deviation 1.28	-0.08 units on a scale Standard Deviation 1.02
Change in Specific Drug Effects (Addiction Research Center Inventory) at 90 Minutes After Drink Administration ARC MBG	3.67 units on a scale Standard Deviation 4.86	-0.38 units on a scale Standard Deviation 2.45	-0.83 units on a scale Standard Deviation 2.55	-0.29 units on a scale Standard Deviation 0.86	-1.29 units on a scale Standard Deviation 2.93	-0.13 units on a scale Standard Deviation 0.95
Change in Specific Drug Effects (Addiction Research Center Inventory) at 90 Minutes After Drink Administration ARC LSD	1.08 units on a scale Standard Deviation 1.89	1.79 units on a scale Standard Deviation 1.93	1.42 units on a scale Standard Deviation 2.69	-0.04 units on a scale Standard Deviation 0.95	0.29 units on a scale Standard Deviation 1.12	0.08 units on a scale Standard Deviation 0.93
Change in Specific Drug Effects (Addiction Research Center Inventory) at 90 Minutes After Drink Administration ARC PCAG	-1.21 units on a scale Standard Deviation 2.17	6.21 units on a scale Standard Deviation 2.92	3.54 units on a scale Standard Deviation 3.68	2.67 units on a scale Standard Deviation 2.96	1.92 units on a scale Standard Deviation 3.22	1.58 units on a scale Standard Deviation 1.91
Change in Specific Drug Effects (Addiction Research Center Inventory) at 90 Minutes After Drink Administration ARC M	2.63 units on a scale Standard Deviation 2.46	2.25 units on a scale Standard Deviation 2.51	2.04 units on a scale Standard Deviation 2.63	0.42 units on a scale Standard Deviation 0.97	0.13 units on a scale Standard Deviation 0.80	0.29 units on a scale Standard Deviation 0.62
Change in Specific Drug Effects (Addiction Research Center Inventory) at 90 Minutes After Drink Administration ARC BG	2.17 units on a scale Standard Deviation 2.39	-2.54 units on a scale Standard Deviation 2.40	-1.71 units on a scale Standard Deviation 2.03	-1.29 units on a scale Standard Deviation 1.63	-1.13 units on a scale Standard Deviation 1.57	-0.67 units on a scale Standard Deviation 1.46

PRIMARY outcome

Timeframe: Measured 15 minutes prior to capsule administration and 120 minutes after drink administration

Population: Participants who completed all sessions

Specific drug effects will be measured using the Addiction Research Center Inventory (Martin et al. 1971). The ARCI measures effects specific to drug classes, including the effects of AMP-like drugs (A scale, 0 to 11), morphine and benzedrine like drugs (MBG scale, 0 to 14), lysergic acid-like drugs (LSD scale, 0 to 14), benzedrine-like drugs (BG scale, 0 to 13), pentobarbital-chlorpromazine and ALC-like drugs (PCAG scale, 0 to 15), and cannabis-like drugs (M scale, 0 to 12). We used this questionnaire as a manipulation check to ensure that the drugs produced their typical drug-specific effects in this study. For example, zero value of A sacle would be minimum report of amphetamine-like drug effects, and 11 would be maximum report of amphetamine-like effects.The change in ARCI was assessed by the difference in measurements between baseline and 120 minutes after drink administration. Baseline was measure 15 minutes prior to capsule administration.

Outcome measures

Measure	AMP Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. AMP arm represents a amphetamine drug session in which participants received a capsule containing d-amphetamine.	ALC Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. ALC arm represents a session in which participants received alcohol beverage.	THC Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. At the THC drug session, they received a capsule containing THC.	AMP Placebo Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. AMP placebo arm represents a session in which participants received a placebo drug.	ALC Placebo Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. ALC placebo arm represents a session in which participants received a placebo beverage.	THC Placebo Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. THC placebo arm represents a session in which participants received a placebo drug.
Change in Specific Drug Effects (Addiction Research Center Inventory) at 120 Minutes After Drink Administration ARC A	2.17 units on a scale Standard Deviation 2.06	-0.33 units on a scale Standard Deviation 1.34	-0.08 units on a scale Standard Deviation 1.21	-0.17 units on a scale Standard Deviation 0.70	-0.71 units on a scale Standard Deviation 1.37	-0.04 units on a scale Standard Deviation 0.86
Change in Specific Drug Effects (Addiction Research Center Inventory) at 120 Minutes After Drink Administration ARC MBG	3.33 units on a scale Standard Deviation 4.35	-1.13 units on a scale Standard Deviation 2.13	-0.96 units on a scale Standard Deviation 2.60	-0.125 units on a scale Standard Deviation 0.85	-1.29 units on a scale Standard Deviation 2.97	-0.08 units on a scale Standard Deviation 0.65
Change in Specific Drug Effects (Addiction Research Center Inventory) at 120 Minutes After Drink Administration ARC LSD	0.38 units on a scale Standard Deviation 1.93	0.79 units on a scale Standard Deviation 1.28	1 units on a scale Standard Deviation 2.83	-0.13 units on a scale Standard Deviation 1.15	0.04 units on a scale Standard Deviation 1.16	-0.08 units on a scale Standard Deviation 0.93
Change in Specific Drug Effects (Addiction Research Center Inventory) at 120 Minutes After Drink Administration ARC BG	1.67 units on a scale Standard Deviation 2.12	-2.04 units on a scale Standard Deviation 1.73	-1.54 units on a scale Standard Deviation 1.64	-1 units on a scale Standard Deviation 1.35	-0.83 units on a scale Standard Deviation 1.55	-0.38 units on a scale Standard Deviation 1.58
Change in Specific Drug Effects (Addiction Research Center Inventory) at 120 Minutes After Drink Administration ARC PCAG	-1.08 units on a scale Standard Deviation 2.02	5.46 units on a scale Standard Deviation 2.93	2.88 units on a scale Standard Deviation 3.49	1.71 units on a scale Standard Deviation 2.65	1.63 units on a scale Standard Deviation 2.76	1.08 units on a scale Standard Deviation 1.98
Change in Specific Drug Effects (Addiction Research Center Inventory) at 120 Minutes After Drink Administration ARC M	1.83 units on a scale Standard Deviation 2.46	1.08 units on a scale Standard Deviation 1.56	1.42 units on a scale Standard Deviation 2.04	0.25 units on a scale Standard Deviation 0.85	-0.04 units on a scale Standard Deviation 0.86	0.17 units on a scale Standard Deviation 0.56

PRIMARY outcome

Timeframe: Measured 15 minutes prior to capsule administration and 150 minutes after drink administration

Population: Participants who completed all sessions

Specific drug effects will be measured using the Addiction Research Center Inventory (Martin et al. 1971). The ARCI measures effects specific to drug classes, including the effects of AMP-like drugs (A scale, 0 to 11), morphine and benzedrine like drugs (MBG scale, 0 to 14), lysergic acid-like drugs (LSD scale, 0 to 14), benzedrine-like drugs (BG scale, 0 to 13), pentobarbital-chlorpromazine and ALC-like drugs (PCAG scale, 0 to 15), and cannabis-like drugs (M scale, 0 to 12). We used this questionnaire as a manipulation check to ensure that the drugs produced their typical drug-specific effects in this study. For example, zero value of A sacle would be minimum report of amphetamine-like drug effects, and 11 would be maximum report of amphetamine-like effects.The change in ARCI was assessed by the difference in measurements between baseline and 150 minutes after drink administration. Baseline was measure 15 minutes prior to capsule administration.

Outcome measures

Measure	AMP Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. AMP arm represents a amphetamine drug session in which participants received a capsule containing d-amphetamine.	ALC Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. ALC arm represents a session in which participants received alcohol beverage.	THC Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. At the THC drug session, they received a capsule containing THC.	AMP Placebo Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. AMP placebo arm represents a session in which participants received a placebo drug.	ALC Placebo Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. ALC placebo arm represents a session in which participants received a placebo beverage.	THC Placebo Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. THC placebo arm represents a session in which participants received a placebo drug.
Change in Specific Drug Effects (Addiction Research Center Inventory) at 150 Minutes After Drink Administration ARC A	2.29 units on a scale Standard Deviation 2.61	-0.54 units on a scale Standard Deviation 1.14	-0.17 units on a scale Standard Deviation 1.63	-0.13 units on a scale Standard Deviation 0.69	-0.54 units on a scale Standard Deviation 1.47	-0.08 units on a scale Standard Deviation 0.83
Change in Specific Drug Effects (Addiction Research Center Inventory) at 150 Minutes After Drink Administration ARC MBG	2.96 units on a scale Standard Deviation 4.39	-1.54 units on a scale Standard Deviation 1.96	-0.96 units on a scale Standard Deviation 2.39	0.13 units on a scale Standard Deviation 0.76	-1.25 units on a scale Standard Deviation 2.88	-0.08 units on a scale Standard Deviation 0.88
Change in Specific Drug Effects (Addiction Research Center Inventory) at 150 Minutes After Drink Administration ARC LSD	0.5 units on a scale Standard Deviation 1.59	0.79 units on a scale Standard Deviation 1.35	0.58 units on a scale Standard Deviation 2.22	0.09 units on a scale Standard Deviation 1.08	-0.13 units on a scale Standard Deviation 1.03	-0.17 units on a scale Standard Deviation 0.82
Change in Specific Drug Effects (Addiction Research Center Inventory) at 150 Minutes After Drink Administration ARC BG	1.75 units on a scale Standard Deviation 2.31	-2.04 units on a scale Standard Deviation 1.65	-1.29 units on a scale Standard Deviation 1.86	-0.43 units on a scale Standard Deviation 1.31	-0.67 units on a scale Standard Deviation 1.24	-0.42 units on a scale Standard Deviation 1.28
Change in Specific Drug Effects (Addiction Research Center Inventory) at 150 Minutes After Drink Administration ARC PCAG	-1 units on a scale Standard Deviation 1.64	5.46 units on a scale Standard Deviation 2.95	2.58 units on a scale Standard Deviation 3.16	0.65 units on a scale Standard Deviation 2.17	1.58 units on a scale Standard Deviation 2.96	0.79 units on a scale Standard Deviation 1.79
Change in Specific Drug Effects (Addiction Research Center Inventory) at 150 Minutes After Drink Administration ARC M	1.54 units on a scale Standard Deviation 1.91	0.75 units on a scale Standard Deviation 1.33	0.83 units on a scale Standard Deviation 1.83	0.22 units on a scale Standard Deviation 0.74	-0.21 units on a scale Standard Deviation 0.78	0.08 units on a scale Standard Deviation 0.41

PRIMARY outcome

Timeframe: Measured 15 minutes prior to capsule administration and 180 minutes after drink administration

Population: Participants who completed all sessions

Specific drug effects will be measured using the Addiction Research Center Inventory (Martin et al. 1971). The ARCI measures effects specific to drug classes, including the effects of AMP-like drugs (A scale, 0 to 11), morphine and benzedrine like drugs (MBG scale, 0 to 14), lysergic acid-like drugs (LSD scale, 0 to 14), benzedrine-like drugs (BG scale, 0 to 13), pentobarbital-chlorpromazine and ALC-like drugs (PCAG scale, 0 to 15), and cannabis-like drugs (M scale, 0 to 12). We used this questionnaire as a manipulation check to ensure that the drugs produced their typical drug-specific effects in this study. For example, zero value of A sacle would be minimum report of amphetamine-like drug effects, and 11 would be maximum report of amphetamine-like effects.The change in ARCI was assessed by the difference in measurements between baseline and 180 minutes after drink administration. Baseline was measure 15 minutes prior to capsule administration.

Outcome measures

Measure	AMP Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. AMP arm represents a amphetamine drug session in which participants received a capsule containing d-amphetamine.	ALC Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. ALC arm represents a session in which participants received alcohol beverage.	THC Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. At the THC drug session, they received a capsule containing THC.	AMP Placebo Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. AMP placebo arm represents a session in which participants received a placebo drug.	ALC Placebo Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. ALC placebo arm represents a session in which participants received a placebo beverage.	THC Placebo Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. THC placebo arm represents a session in which participants received a placebo drug.
Change in Specific Drug Effects (Addiction Research Center Inventory) at 180 Minutes After Drink Administration ARC A	1.58 units on a scale Standard Deviation 2.26	-0.75 units on a scale Standard Deviation 1.19	-0.21 units on a scale Standard Deviation 1.44	-0.04 units on a scale Standard Deviation 0.91	-0.33 units on a scale Standard Deviation 1.69	-0.17 units on a scale Standard Deviation 1.13
Change in Specific Drug Effects (Addiction Research Center Inventory) at 180 Minutes After Drink Administration ARC MBG	1.92 units on a scale Standard Deviation 4.03	-1.29 units on a scale Standard Deviation 1.88	-0.67 units on a scale Standard Deviation 2.37	0.33 units on a scale Standard Deviation 1.24	-1.08 units on a scale Standard Deviation 3.01	-0.17 units on a scale Standard Deviation 0.82
Change in Specific Drug Effects (Addiction Research Center Inventory) at 180 Minutes After Drink Administration ARC LSD	0.46 units on a scale Standard Deviation 1.91	0.54 units on a scale Standard Deviation 1.02	0.54 units on a scale Standard Deviation 1.82	0.04 units on a scale Standard Deviation 1.04	-0.04 units on a scale Standard Deviation 0.81	0.04 units on a scale Standard Deviation 0.95
Change in Specific Drug Effects (Addiction Research Center Inventory) at 180 Minutes After Drink Administration ARC BG	1.13 units on a scale Standard Deviation 2.15	-1.5 units on a scale Standard Deviation 1.47	-1.29 units on a scale Standard Deviation 1.78	-0.33 units on a scale Standard Deviation 1.13	-0.38 units on a scale Standard Deviation 1.41	-0.29 units on a scale Standard Deviation 1.20
Change in Specific Drug Effects (Addiction Research Center Inventory) at 180 Minutes After Drink Administration ARC PCAG	-0.46 units on a scale Standard Deviation 1.93	3.63 units on a scale Standard Deviation 3.01	2.13 units on a scale Standard Deviation 3.43	0.21 units on a scale Standard Deviation 2.50	0.71 units on a scale Standard Deviation 2.73	0.42 units on a scale Standard Deviation 1.59
Change in Specific Drug Effects (Addiction Research Center Inventory) at 180 Minutes After Drink Administration ARC M	1.21 units on a scale Standard Deviation 1.59	0.08 units on a scale Standard Deviation 1.02	0.71 units on a scale Standard Deviation 1.94	0.13 units on a scale Standard Deviation 0.68	-0.13 units on a scale Standard Deviation 0.74	-0.08 units on a scale Standard Deviation 0.28

PRIMARY outcome

Timeframe: Measured 15 minutes prior to capsule administration and 210 minutes after drink administration

Population: Participants who completed all sessions

Specific drug effects will be measured using the Addiction Research Center Inventory (Martin et al. 1971). The ARCI measures effects specific to drug classes, including the effects of AMP-like drugs (A scale, 0 to 11), morphine and benzedrine like drugs (MBG scale, 0 to 14), lysergic acid-like drugs (LSD scale, 0 to 14), benzedrine-like drugs (BG scale, 0 to 13), pentobarbital-chlorpromazine and ALC-like drugs (PCAG scale, 0 to 15), and cannabis-like drugs (M scale, 0 to 12). We used this questionnaire as a manipulation check to ensure that the drugs produced their typical drug-specific effects in this study. For example, zero value of A sacle would be minimum report of amphetamine-like drug effects, and 11 would be maximum report of amphetamine-like effects.The change in ARCI was assessed by the difference in measurements between baseline and 210 minutes after drink administration. Baseline was measure 15 minutes prior to capsule administration.

Outcome measures

Measure	AMP Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. AMP arm represents a amphetamine drug session in which participants received a capsule containing d-amphetamine.	ALC Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. ALC arm represents a session in which participants received alcohol beverage.	THC Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. At the THC drug session, they received a capsule containing THC.	AMP Placebo Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. AMP placebo arm represents a session in which participants received a placebo drug.	ALC Placebo Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. ALC placebo arm represents a session in which participants received a placebo beverage.	THC Placebo Arm n=24 Participants All healthy adult volunteers completed a 6 session; The three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. THC placebo arm represents a session in which participants received a placebo drug.
Change in Specific Drug Effects (Addiction Research Center Inventory) at 210 Minutes After Drink Administration ARC LSD	0.63 units on a scale Standard Deviation 1.79	0.33 units on a scale Standard Deviation 0.92	0.54 units on a scale Standard Deviation 1.22	0.25 units on a scale Standard Deviation 0.90	1.67 units on a scale Standard Deviation 0.87	0.04 units on a scale Standard Deviation 1.04
Change in Specific Drug Effects (Addiction Research Center Inventory) at 210 Minutes After Drink Administration ARC BG	0.83 units on a scale Standard Deviation 1.61	-1.25 units on a scale Standard Deviation 1.39	-0.83 units on a scale Standard Deviation 1.40	-0.17 units on a scale Standard Deviation 0.82	-0.38 units on a scale Standard Deviation 1.06	-0.13 units on a scale Standard Deviation 1.48
Change in Specific Drug Effects (Addiction Research Center Inventory) at 210 Minutes After Drink Administration ARC PCAG	-0.29 units on a scale Standard Deviation 2.10	3.17 units on a scale Standard Deviation 3.17	1.04 units on a scale Standard Deviation 1.76	-0.29 units on a scale Standard Deviation 1.43	0.21 units on a scale Standard Deviation 2.55	0.13 units on a scale Standard Deviation 1.68
Change in Specific Drug Effects (Addiction Research Center Inventory) at 210 Minutes After Drink Administration ARC M	0.96 units on a scale Standard Deviation 1.97	0.08 units on a scale Standard Deviation 0.97	0.21 units on a scale Standard Deviation 0.72	0 units on a scale Standard Deviation 0.42	-0.17 units on a scale Standard Deviation 0.70	-0.08 units on a scale Standard Deviation 0.28
Change in Specific Drug Effects (Addiction Research Center Inventory) at 210 Minutes After Drink Administration ARC A	1.0 units on a scale Standard Deviation 1.93	-0.71 units on a scale Standard Deviation 1.20	-0.46 units on a scale Standard Deviation 1.06	-0.17 units on a scale Standard Deviation 0.82	-0.54 units on a scale Standard Deviation 1.50	0.08 units on a scale Standard Deviation 1.21
Change in Specific Drug Effects (Addiction Research Center Inventory) at 210 Minutes After Drink Administration ARC MBG	1.38 units on a scale Standard Deviation 3.31	-1.17 units on a scale Standard Deviation 2.08	-0.88 units on a scale Standard Deviation 1.92	0.13 units on a scale Standard Deviation 1.15	-0.79 units on a scale Standard Deviation 2.95	0.04 units on a scale Standard Deviation 0.86

Adverse Events

Healthy Adult Volunteers

Serious events: 0 serious events

Other events: 1 other events

Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Measure

Healthy Adult Volunteers n=28 participants at risk 24 healthy adult volunteers completed a 6 session within-subject, double-blind, placebo-controlled trial. At three of these sessions, they received one of three recreational drugs, d-amphetamine, THC and alochol (only one drug was administered per drug session). The other three sessions were matched placebo sessions. At each session, they received a capsule and a drink. At the amphetamine drug session, they received a capsule containing d-amphetamine and a placebo beverage. At the THC drug session, they received a capsule containing THC and a placebo beverage. At the alcohol drug session they received a placebo capsule and a beverage containing alcohol. At the three matched placebo sessions, both the capsule and the beverage were placebo.

Gastrointestinal disorders vomiting from alcohol dose

3.6% 1/28 • Number of events 1 • During study only (1 Day)

Additional Information

Dr. Harriet de Wit

University of Chicago

Phone: 773-702-1537

Email: hdew@uchicago.edu

Results disclosure agreements

• Principal investigator is a sponsor employee
• Publication restrictions are in place