STI Combined to Valsalva Maneuver for the Diagnosis of Left Ventricular Dysfunction in COPD Exacerbations

NCT ID: NCT02481908

Last Updated: 2020-09-14

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 189 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2012-04-30
• Study Completion Date: 2013-12-31

Brief Summary

The aim of this investigation was to assess the value of Systolic Time Intervals (STIs) as a method of detecting Left Ventricular Dysfunction (LVD) in patients admitted to the emergency department for cute exacerbations of chronic obstructive pulmonary disease (AECOPD) and whether STIs measured under Valsalva manoeuver (VM) could improve the distinction between patients with LVD and those without LVD.

Detailed Description

We included patients admitted to the ED for AECOPD. Measurement of STIs included electromechanical activation time (EMAT), left ventricular ejection time and EMAT/LVET ratio. These were performed at baseline and during the first strain phase of the VM using a computerized phono and electrocardiographic method. The diagnosis of LVD was determined on the basis of clinical examination, echocardiography and brain natriuretic peptide. The values of STIs were compared between patients with and without LVD ; their diagnostic performance was assessed using the area under receiver operating characteristic curve (AUC of ROC).

Conditions

Obstructive Chronic Bronchitis With Acute Exacerbation

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Interventions

STI measurements at baseline and under Valsalva maneuver

STI measurements at baseline and under Valsalva maneuver

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

• Oxygen Saturation (SPO2) <90%,
• Respiratory Rate >25c/min,
• PaCO2 > 6 kPa et pH< 7.35.

Exclusion Criteria

• Neurological distress and hemodynamic instability
• Confusion, agitation
• pneumothorax
• Non cooperative patients
• Refusal of consent

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

University of Monastir

OTHER

Sponsor Role: lead

Responsible Party

Pr. Semir Nouira

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

SEMIR NOUIRA, Pr

Role: PRINCIPAL_INVESTIGATOR

Fattouma Bourguiba University Hospital

Locations

CHU Fattouma Bourguiba

Monastir, , Tunisia

Countries

Tunisia

Other Identifiers

STI in COPD

Identifier Type: -

Identifier Source: org_study_id