Expanded Access Program With Nivolumab Therapy for Treatment of Advanced/Metastatic SqNSCLC or Non-SqNSCLC After One Prior Systemic Regimen

NCT ID: NCT02475382

Last Updated: 2020-11-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NO_LONGER_AVAILABLE

Study Classification

EXPANDED_ACCESS

Brief Summary

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The purpose of this study is to provide treatment with nivolumab, a fully human monoclonal antibody, to subjects who have relapsed after treatment with a minimum of 1 prior systemic treatment for advanced or metastatic squamous (Sq) or non-squamous (non-Sq) non-small cell lung cancer (NSCLC) , Stage IIIB/IV and whose physicians believe that nivolumab treatment is appropriate.

Detailed Description

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Conditions

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Squamous Non-Small Cell Lung Cancer Non-squamous Non-Small Cell Lung Cancer

Interventions

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Nivolumab

Specified dose on specified days

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Sq or Non-Sq NSCLC, Stage IIIb/IV (histologically or cytologically confirmed)
* Relapsed after 1 prior platinum-based systemic treatment
* Eastern Cooperative Oncology Group (ECOG) Performance Status \< 2
* CNS metastasis must be treated and returned to baseline at least 2 weeks before first dose of nivolumab and off steroids or using stable or decreasing dose of \< 10 mg prednisone or equivalent
* Prior chemotherapy, Tyrosine Kinase Inhibitor (TKI) therapy or Immunotherapy (tumor vaccine, cytokine or growth factor to control cancer) must be completed at least 2 weeks before first nivolumab dose

Exclusion Criteria

* CNS metastases (untreated and/or symptomatic)
* Carcinomatous meningitis
* ECOG Performance status \> 3
* Corticosteroids \> 10 mg prednisolone/day (or equivalent)
* Prior treatment with anti-PD-1, anti-PD-L-1, anti-PDL2, anti-CT137 or anti-CTLA antibody, including ipilimumab or any other drugs specifically targeting T cell costimulation or checkpoint pathways
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Bristol-Myers Squibb

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Bristol-Myers Squibb

Role: STUDY_DIRECTOR

Bristol-Myers Squibb

Locations

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Local Institution

Fortaleza, Ceará, Brazil

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Fortaleza, Ceará, Brazil

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Salvador, Estado de Bahia, Brazil

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Brasília, Federal District, Brazil

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Distrito Federal, Federal District, Brazil

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Belo Horizonte, Minas Gerais, Brazil

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Cascavel, Paraná, Brazil

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Curitiba, Paraná, Brazil

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Curitiba, Paraná, Brazil

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Recife, Pernambuco, Brazil

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Recife, Pernambuco, Brazil

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Natal, Rio Grande do Norte, Brazil

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Ijuí, Rio Grande do Sul, Brazil

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Passo Fundo, Rio Grande do Sul, Brazil

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Porto Alegre, Rio Grande do Sul, Brazil

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Porto Alegre, Rio Grande do Sul, Brazil

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Porto Alegre, Rio Grande do Sul, Brazil

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Porto Alegre, Rio Grande do Sul, Brazil

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Florianópolis, Santa Catarina, Brazil

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Itajaí, Santa Catarina, Brazil

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Barretos, São Paulo, Brazil

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Campinas, São Paulo, Brazil

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Jaú, São Paulo, Brazil

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Ribeirão Preto, São Paulo, Brazil

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Santo André, São Paulo, Brazil

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Rio de Janeiro, , Brazil

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Rio de Janeiro, , Brazil

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Salvador, , Brazil

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São Paulo, , Brazil

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São Paulo, , Brazil

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São Paulo, , Brazil

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São Paulo, , Brazil

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São Paulo, , Brazil

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São Paulo, , Brazil

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São Paulo, , Brazil

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Edmonton, Alberta, Canada

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Burnaby, British Columbia, Canada

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Kelowna, British Columbia, Canada

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Richmond, British Columbia, Canada

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Winnipeg, Manitoba, Canada

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Moncton, New Brunswick, Canada

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Greater Sudbury, Ontario, Canada

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Hamilton, Ontario, Canada

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Oshawa, Ontario, Canada

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Thunder Bay, Ontario, Canada

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Toronto, Ontario, Canada

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Chicoutimi, Quebec, Canada

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Greenfield Park, Quebec, Canada

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Montreal, Quebec, Canada

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Centre De Sante Et De Services Sociaux Rimouski Neigette

Rimouski, Quebec, Canada

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Countries

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Brazil Canada

References

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Parodi D, Dighero E, Biddau G, D'Amico F, Bauckneht M, Marini C, Garbarino S, Campi C, Piana M, Sambuceti G. Localized FDG loss in lung cancer lesions. EJNMMI Res. 2024 Nov 1;14(1):102. doi: 10.1186/s13550-024-01161-y.

Reference Type DERIVED
PMID: 39485534 (View on PubMed)

Related Links

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Other Identifiers

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CA209-169

Identifier Type: -

Identifier Source: org_study_id