Clinical Outcomes Study of the Nexel Total Elbow

NCT ID: NCT02469662

Last Updated: 2025-10-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

134 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-06-30

Study Completion Date

2036-12-31

Brief Summary

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The objectives of the study are to confirm safety and performance of the Zimmer Nexel Total Elbow when used in primary or revision total elbow replacement.

Detailed Description

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The objectives of the study are to confirm safety and performance of the Zimmer® Nexel™ Total Elbow when used in primary or revision total elbow replacement by analysis of standard scoring systems, radiographs, and adverse event records.

The safety of the device will be monitored using the frequency and incidence of reporting adverse events.

The performance of the device will be evaluated by assessing the pain and functional performance, survival of the device, patient health status, and radiographic success of the implant.

Conditions

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Elbow Joint Destruction Post-traumatic Lesions Ankylosed Joints Advanced Rheumatoid Arthritis Joint Instability or Loss of Motion Acute Comminuted Articular Fracture of Elbow Joint Surfaces Bone Loss Contributing to Elbow Instability Bilateral Ankylosis From Causes Other Than Active Sepsis Post-traumatic Arthritis Degenerative Arthritis

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Retrospective

Patients who have had primary or revision total elbow arthroplasty using the Nexel Total Elbow, and who have surgical details available

Group Type EXPERIMENTAL

Nexel Total Elbow

Intervention Type DEVICE

Nexel Total Elbow used in primary or revision total elbow arthroplasty

Prospective

Patients who are having primary or revision total elbow arthroplasty who will receive the Nexel Total Elbow

Group Type EXPERIMENTAL

Nexel Total Elbow

Intervention Type DEVICE

Nexel Total Elbow used in primary or revision total elbow arthroplasty

Interventions

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Nexel Total Elbow

Nexel Total Elbow used in primary or revision total elbow arthroplasty

Intervention Type DEVICE

Other Intervention Names

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Nexel Elbow Nexel

Eligibility Criteria

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Inclusion Criteria

* Patient is 18 years of age or older.
* Patient must have signed Institutional Review Board (IRB)/Ethics Committee (EC)-approved informed consent.
* Patient is a candidate for primary or revision total elbow arthroplasty, based on symptoms including at least one of the following:

* Elbow joint destruction which significantly compromises daily living activities
* Post-traumatic lesions or bone loss contributing to elbow instability
* Ankylosed joints, especially cases of bilateral ankylosis from causes other than active sepsis
* Advanced rheumatoid arthritis, post-traumatic, or degenerative arthritis with incapacitating pain
* Instability or loss of motion when the degree of joint or soft tissue damage precludes reliable osteosynthesis
* Acute comminuted articular fracture of elbow joint surfaces that precludes less radical procedures, including 13-C3 fractures of the distal humerus
* Patient is willing and able to complete scheduled follow-up evaluations as defined by the protocol.


* Patient must have undergone a total elbow replacement with the Nexel system between July 2013 and the date of the site initiation visit.
* Patient information available for each retrospective patient must, at minimum, include preoperative demographic information, preoperative physical exam information, the index surgery operative report, and details of the devices implanted.

Exclusion Criteria

* Patient has a currently active or history of repeated local infection at the surgical site.
* Patient has a current major infection distant from the operative site.
* Patient has a history of prior sepsis.
* Patient suffers from paralysis or dysfunctional neuropathy at the elbow joint.
* Patient has significant ipsilateral hand dysfunction.
* Patient has excessive scarring near the surgical site, which could prevent adequate soft tissue coverage.
* Patient participates in daily activities that may cause significant stress to an implanted device such as heavy labor, torsional stress, and/or competitive sports.
* Patient is a prisoner.
* Patient is mentally incompetent or unable to understand what participation in the study entails.
* Patient is a known alcohol or drug abuser.
* Patient is anticipated to be non-compliant.
* Patient is known to be pregnant.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Zimmer Biomet

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Hillary Overholser, MS

Role: STUDY_DIRECTOR

Zimmer Biomet

Locations

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Panorama Orthopedics and Spine Center

Golden, Colorado, United States

Site Status RECRUITING

OrthoCarolina Research Institute

Charlotte, North Carolina, United States

Site Status RECRUITING

Rothman Institute

Philadelphia, Pennsylvania, United States

Site Status RECRUITING

Campbell Clinic

Germantown, Tennessee, United States

Site Status RECRUITING

Sydney Shoulder & Elbow, NSW

Sydney, New South Wales, Australia

Site Status TERMINATED

Coxa Hospital

Tampere, , Finland

Site Status RECRUITING

Hôpital Purpan (Centre Hospitalier Universitaire Toulouse)

Toulouse, , France

Site Status TERMINATED

Arcus Sportklinik

Pforzheim, , Germany

Site Status TERMINATED

AO Mauriziano

Torino, , Italy

Site Status RECRUITING

Amphia Ziekenhuis Breda

Breda, , Netherlands

Site Status ACTIVE_NOT_RECRUITING

Wrightington

Wigan, , United Kingdom

Site Status RECRUITING

Countries

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United States Australia Finland France Germany Italy Netherlands United Kingdom

Central Contacts

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Richard Marek

Role: CONTACT

574-453-7567

Ryan Boylan

Role: CONTACT

574-527-7934

Facility Contacts

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Paul Lee

Role: primary

Caleb Lifsey

Role: primary

704-323-2262

Justin Norwood

Role: backup

704-323-3845

Anuhya Peruri

Role: primary

267-386-2474

Thema Nicholson

Role: backup

Margaret Knack

Role: primary

Davide Blonna

Role: primary

+39 011 508 1111

Other Identifiers

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CMU2014-06E

Identifier Type: -

Identifier Source: org_study_id

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