Study in Children With the Diagnosis of Congenital Diaphragmatic Hernia (CDH) and Oesophageal Atresia (EA)

NCT ID: NCT02466451

Last Updated: 2016-03-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

33 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-03-31

Study Completion Date

2015-05-31

Brief Summary

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Observational longitudinal study in children operated at birth on diaphragmatic hernia and/or oesophageal atresia : assessment of lung function parameters; assessment of quality of life and cognitive development; assessment of stress parenting and strategies of adaptation.

Detailed Description

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Observational longitudinal study in children operated at birth on diaphragmatic hernia and/or oesophageal atresia : assessment of lung function parameters; assessment of quality of life and cognitive development; assessment of stress parenting and strategies of adaptation.

Tools: Anamnestic-clinical questionnaire, Spirometry, Plethysmography, Fractional exhaled nitric oxide (FeNO) assessment (oral and alveolar ), 6-minutes walk test (WT 6'), Prick tests, Quality of life in children questionnaire(KINDL, quality of life), Psychological test for cognitive development (Raven Matrices)

Conditions

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Diaphragmatic Hernia Oesophageal Atresia

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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Children operated at birth on CDH and EA

Standardized Questionnaires:For not collaborative patients,\< 4 years:Standardized questionnaire collecting anamnestic-clinical data;Stress Parenting Index questionnaire and COPE brief questionnaire(Questionnaire assessing adaptation strategies of parents) For collaborative patients, \>4 years:Standardized questionnaire collecting anamnestic-clinical data;Fractional exhaled nitric oxide (FeNO) assessment (oral and alveolar);Spirometry;6-minutes walk test (WT 6'); Prick tests;Children Quality of life questionnaire (KINDL questionnaire);Psychological test (Raven Matrices);Stress Parenting Index questionnaire and COPE brief questionnaire (Questionnaire assessing adaptation strategies of parents).

Questionnaires

Intervention Type OTHER

For not collaborative patients, under the age of 4 years:

* Standardized questionnaire collecting anamnestic-clinical data
* Stress Parenting Index questionnaire and COPE brief questionnaire(Questionnaire assessing adaptation strategies of parents).

For collaborative patients, over the age of 4 years:

* Standardized questionnaire collecting anamnestic-clinical data
* Fractional exhaled nitric oxide (FeNO) assessment (oral and alveolar )
* Spirometry
* 6-minutes walk test (WT 6')
* Prick tests
* Children Quality of life questionnaire (KINDL questionnaire)
* Psychological test (Raven Matrices)
* Stress Parenting Index questionnaire and COPE brief questionnaire (Questionnaire assessing adaptation strategies of parents)

Interventions

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Questionnaires

For not collaborative patients, under the age of 4 years:

* Standardized questionnaire collecting anamnestic-clinical data
* Stress Parenting Index questionnaire and COPE brief questionnaire(Questionnaire assessing adaptation strategies of parents).

For collaborative patients, over the age of 4 years:

* Standardized questionnaire collecting anamnestic-clinical data
* Fractional exhaled nitric oxide (FeNO) assessment (oral and alveolar )
* Spirometry
* 6-minutes walk test (WT 6')
* Prick tests
* Children Quality of life questionnaire (KINDL questionnaire)
* Psychological test (Raven Matrices)
* Stress Parenting Index questionnaire and COPE brief questionnaire (Questionnaire assessing adaptation strategies of parents)

Intervention Type OTHER

Other Intervention Names

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Standardized Questionnaires

Eligibility Criteria

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Inclusion Criteria

* Children operated at birth on diaphragmatic hernia and/or oesophageal atresia
* Written informed consent, signed by parents

Exclusion Criteria

* Children that have had infections in the last 4 weeks
* Children with ongoing diseases
* Children that take drugs able to modify the lung function
Minimum Eligible Age

5 Months

Maximum Eligible Age

12 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Stefania La Grutta, MD

OTHER

Sponsor Role lead

Responsible Party

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Stefania La Grutta, MD

Senior Researcher

Responsibility Role SPONSOR_INVESTIGATOR

Other Identifiers

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5/2012

Identifier Type: -

Identifier Source: org_study_id

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