Effect of AT-derived miRNA on the Biology and Insulin Sensitivity of Skeletal Muscle in Humans

NCT ID: NCT02459106

Last Updated: 2025-03-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

46 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-05-27

Study Completion Date

2024-12-19

Brief Summary

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The purpose of this study is examine the effect of fat tissue-released miRNA on skeletal muscle and if abnormal fat tissue-released miRNA contributes to insulin resistance in obese individuals. This information will be important for our understanding of how the body's sugar metabolism is regulated and why people who are obese become insulin resistant and are more likely to develop type 2 diabetes.

Detailed Description

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Study Objectives:

1. To establish and optimize the methodology for measuring adipose tissue miRNA release.
2. To establish and optimize the methodology for measuring the effect of adipose tissue-released miRNA on skeletal muscle biology and insulin sensitivity.
3. To profile adipose tissue-released miRNA in lean insulin-sensitive and obese insulin-resistant healthy individuals.
4. To examine the effects of adipose tissue-released miRNA from lean insulin-sensitive individuals and obese insulin-resistant individuals on skeletal muscle biology and insulin sensitivity.

Conditions

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Type 2 Diabetes Mellitus

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Healthy lean insulin-sensitive individuals

This group will be studied by measuring the adipose tissue miRNA release, adipose tissue-released miRNA will be profiled, and these effects will be examined.

No interventions assigned to this group

Obese insulin-resistant individuals

This group will be studied by measuring the effect of adipose tissue-release miRNA on skeletal muscle biology and insulin sensitivity, adipose tissue-released miRNA will be profiled, and these effects will be examined on obese insulin-resistant individuals on skeletal muscle biology and insulin sensitivity.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Able to communicate meaningfully with the investigator and legally competent to provide informed written consent
* 18-65 years of age
* BMI of 20-25 kg/m2 (lean subjects); 30-35 kg/m2 (obese subjects)
* Stable body weight (\< 3 kg change in the last 8 weeks)
* homeostatic model assessment (HOMA)-insulin resistance \<2.7 if lean; homeostatic model assessment (HOMA)-insulin resistance ≥2.7 if obese

Exclusion Criteria

* Lactation or pregnancy, current and/or within last 6 months, per participant's report
* Female subjects postmenopausal
* Cardiovascular disease (unstable angina, myocardial infarction or coronary revascularization within 6 months)
* Liver disease (AST or ALT(alanine aminotransferase)\>2.5 times the upper limit of normal)
* Kidney disease (creatinine \>1.6 mg/dl)
* Anemia (hemoglobin \<12 g/dl in men, \<11 g/dl in women)
* Thyroid dysfunction (abnormal TSH)
* HbA1c ≥6.5%
* Uncontrolled hypertension (systolic BP\>160 mmHg, diastolic BP\>100 mmHg)
* History of coagulopathies
* History (within the last 5 years) or presence of malignancy, (skin cancers, with the exception of melanoma, may be acceptable)
* Current or history of drug abuse or alcohol abuse (\>2 drinks/day)
* Prior treatment (within last 3 months) with systemic glucocorticoids (\>2 weeks), beta-blockers, drugs for weight loss, niacin or fibrates
* History of HIV, active Hepatitis B or C, or Tuberculosis (participant reported)
* Smoke \> 5 cigarettes per day
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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AdventHealth Translational Research Institute

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Richard Pratley, MD

Role: PRINCIPAL_INVESTIGATOR

Translational Research Institute for Metabolism and Diabetes

Locations

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Translational Research Institute for Metabolism and Diabetes

Orlando, Florida, United States

Site Status

Countries

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United States

References

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Related Links

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http://www.tri-md.org

Translational Research Institute for Metabolism and Diabetes

Other Identifiers

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TRIMDFH 729828

Identifier Type: -

Identifier Source: org_study_id

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