In Vivo and ex Vivo Validation of MR Tractography of Brain White Matter Tracts - FIBRATLAS II-III
NCT ID: NCT02455284
Last Updated: 2025-12-30
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
134 participants
INTERVENTIONAL
2015-10-31
2021-02-28
Brief Summary
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Diffusion Weighted Imaging (DWI) is a non-invasive MRI (Magnetic Resonance Imaging) technique providing information on white matter tracts (tractography) by studying water diffusion. Since it is based on complex mathematical models that only indirectly evaluates the underlying anatomy, tractography need to be validated before being used for research and clinical purposes. Several validation techniques were previously proposed, none of them being fully convincing in human.
Detailed Description
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Conditions
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Keywords
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Study Design
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NA
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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Healthy subjects
MRI and neuropsychological evaluation
MRI
In vivo MRI with B0 cartography, FLAIR, 3D T1 anatomic images, DWI, and Tractography from DWI images
Interventions
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MRI
In vivo MRI with B0 cartography, FLAIR, 3D T1 anatomic images, DWI, and Tractography from DWI images
Eligibility Criteria
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Inclusion Criteria
* Age ≥ 82 years
* Absence of major cognitive impairment as demonstrated by independent living skills in 4 fields evaluated by the IADL (4 items) (Lawton and Brody, 1969)
* Distance to one of the participating laboratories ≤ 120km
* Able to remain supine in the MR scanner for acquisition duration (60 min),
* Affiliation to Social Security
* Informed and written consent
* Past or present Neurological or Neurosurgical diseases (excluding trauma or degenerative spinal lesions)
* Uncontrolled: High blood pressure, diabetes (types I or II), or dyslipemia
* Contraindications to MRI
* Contraindication to body donation
Exclusion Criteria
82 Years
ALL
Yes
Sponsors
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University Hospital, Tours
OTHER
Responsible Party
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Principal Investigators
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Christophe DESTRIEUX, PhD
Role: PRINCIPAL_INVESTIGATOR
University Hospital of Tours
Locations
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University Hospital of Amiens
Amiens, , France
University Hospital of Angers
Angers, , France
University Hospital of Brest
Brest, , France
Hospital of Charpennes - Lyon
Lyon, , France
University Hospital of Nancy
Nancy, , France
University Hospital of Rennes
Rennes, , France
University Hospital of Tours
Tours, , France
Countries
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References
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Sizaret E, Brachet M, Launay A, Destrieux C, Zemmoura I, Angel L; FIBRATLAS Consortium. Norms for neuropsychological tests in cognitively healthy French oldest old adults. J Int Neuropsychol Soc. 2024 Nov;30(9):841-855. doi: 10.1017/S1355617724000390. Epub 2024 Sep 18.
Other Identifiers
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ANR 14 - CD / FIBRATLAS
Identifier Type: -
Identifier Source: org_study_id