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Effectiveness of Four Popular Diet Strategies for Weight Loss and Cardiac Risk Reduction

NCT ID: NCT02454127

Last Updated: 2016-10-31

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

160 participants

Study Classification

INTERVENTIONAL

Study Start Date

2000-07-31

Study Completion Date

2004-01-31

Brief Summary

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A single-center randomized trial at an academic medical center in Boston, Mass, of overweight or obese adults with known hypertension, dyslipidemia, or fasting hyperglycemia. Participants were enrolled starting July 18, 2000, and randomized to 4 popular diet groups until January 24, 2002.

Detailed Description

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Objective: To assess adherence rates and the effectiveness of 4 popular diets (Atkins, Zone, Weight Watchers, and Ornish) for weight loss and cardiac risk factor reduction.

Design, Setting, and Participants: A single-center randomized trial at an academic medical center in Boston, Mass, of overweight or obese adults with known hypertension, dyslipidemia, or fasting hyperglycemia. Participants were enrolled starting July 18, 2000, and randomized to 4 popular diet groups until January 24, 2002.

Intervention: A total of 160 participants were randomly assigned to either Atkins (carbohydrate restriction, n=40), Zone (macronutrient balance, n=40), Weight Watchers (calorie restriction, n=40), or Ornish (fat restriction, n=40) diet groups. After 2 months of maximum effort, participants selected their own levels of dietary adherence.

Main Outcome Measures: One-year changes in baseline weight and cardiac risk factors, and self-selected dietary adherence rates per self-report. Outcome measures included body weight, total cholesterol, LDL-C, HDL-C, triglycerides, hsCRP, insulin, glucose.

Conditions

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Obesity Cardiovascular Disease Metabolic Syndrome

Keywords

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nutrition popular diets weight loss lifestyle counseling

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Atkins Diet

Atkins Diet (dietary counseling)

Group Type ACTIVE_COMPARATOR

Atkins Diet

Intervention Type BEHAVIORAL

Dietary counseling for 1 year

Zone Diet

Zone Diet (dietary counseling)

Group Type ACTIVE_COMPARATOR

Zone Diet

Intervention Type BEHAVIORAL

Dietary counseling for 1 year

Weight Watchers Diet

Weight Watchers Diet (dietary counseling)

Group Type ACTIVE_COMPARATOR

Weight Watchers Diet

Intervention Type BEHAVIORAL

Dietary counseling for 1 year

Ornish Diet

Ornish Diet (dietary counseling)

Group Type ACTIVE_COMPARATOR

Ornish Diet

Intervention Type BEHAVIORAL

Dietary counseling for 1 year

Interventions

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Atkins Diet

Dietary counseling for 1 year

Intervention Type BEHAVIORAL

Zone Diet

Dietary counseling for 1 year

Intervention Type BEHAVIORAL

Weight Watchers Diet

Dietary counseling for 1 year

Intervention Type BEHAVIORAL

Ornish Diet

Dietary counseling for 1 year

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* BMI 27-42;
* At least one metabolic cardiac risk factor

Exclusion Criteria

* Age under 18 years;
* Insulin therapy;
* Unstable chronic illness;
* Unwilling to follow dietary advice
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Tufts Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Michael L Dansinger, MD

Role: PRINCIPAL_INVESTIGATOR

Tufts Medical Center

References

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Dansinger ML, Gleason JA, Griffith JL, Selker HP, Schaefer EJ. Comparison of the Atkins, Ornish, Weight Watchers, and Zone diets for weight loss and heart disease risk reduction: a randomized trial. JAMA. 2005 Jan 5;293(1):43-53. doi: 10.1001/jama.293.1.43.

Reference Type RESULT
PMID: 15632335 (View on PubMed)

Other Identifiers

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DANS0001

Identifier Type: -

Identifier Source: org_study_id