STAND UP - Sedentary Behaviour in Older Adults: Investigating a New Therapeutic Paradigm

NCT ID: NCT02453204

Last Updated: 2020-01-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

76 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-04-30

Study Completion Date

2017-03-31

Brief Summary

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Research has shown that reducing the time spent sitting can reduce the risk of many diseases, such as diabetes and heart disease, and improve health. It is estimated that many older adults typically spend 70% of their waking day sitting, but little is known about whether reducing sitting promotes health and well-being in this age group. The aim of this research is to investigate the health effects of reducing sitting time by replacing it with short periods of standing or walking in adults over the age of 65.

Detailed Description

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Conditions

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Older Adults

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Sitting

Participants will remain sitting throughout the test period whilst undertaking typical sedentary behaviours such as watching TV, using a computer, reading and writing. Walking and standing will be restricted.

Group Type EXPERIMENTAL

Sitting

Intervention Type BEHAVIORAL

Standing

Participants will be asked to break their sitting time by standing for five minutes every 30 minutes. Participants will be asked to stand in the same position with no further instructions provided. In total, individuals will accumulate 12 bouts (60 minutes) of standing throughout the test period.

Group Type EXPERIMENTAL

Standing

Intervention Type BEHAVIORAL

Walking

The walking condition will be identical to standing, but the breaks in sitting time will be punctuated with five minute bouts of self-paced walking rather than standing.

Group Type EXPERIMENTAL

Walking

Intervention Type BEHAVIORAL

Interventions

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Sitting

Intervention Type BEHAVIORAL

Standing

Intervention Type BEHAVIORAL

Walking

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Adults aged between 65 to 79 years inclusive
* Able to walk (without any assistive devices and not requiring assistance from another person)
* Ability to communicate in and understand English to participate in the informed consent process.

Exclusion Criteria

* Regular purposeful exercise (≥75 minutes of self-reported vigorous exercise per week)
* Inability to stand or undertake light ambulation
* Psychological condition which limits participation in the study (e.g. dementia)
* Inability to communicate or understand English
* Steroid use
* Use of glucose lowering medication
* Inability to give informed consent
Minimum Eligible Age

65 Years

Maximum Eligible Age

79 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Glasgow

OTHER

Sponsor Role collaborator

National Institute for Health Research, United Kingdom

OTHER_GOV

Sponsor Role collaborator

National Health Service, United Kingdom

OTHER_GOV

Sponsor Role collaborator

University of Leicester

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Thomas Yates

Role: PRINCIPAL_INVESTIGATOR

University of Leicester

Locations

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BHF Glasgow Cardiovascular Research Centre, University of Glasgow, 126 University Avenue

Glasgow, , United Kingdom

Site Status

Leicester Diabetes Centre, Diabetes Research Unit, University of Leicester, Leicester General Hospital

Leicester, , United Kingdom

Site Status

Countries

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United Kingdom

References

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Yates T, Edwardson CL, Celis-Morales C, Biddle SJH, Bodicoat D, Davies MJ, Esliger D, Henson J, Kazi A, Khunti K, Sattar N, Sinclair AJ, Rowlands A, Velayudhan L, Zaccardi F, Gill JMR. Metabolic Effects of Breaking Prolonged Sitting With Standing or Light Walking in Older South Asians and White Europeans: A Randomized Acute Study. J Gerontol A Biol Sci Med Sci. 2020 Jan 1;75(1):139-146. doi: 10.1093/gerona/gly252.

Reference Type DERIVED
PMID: 30403772 (View on PubMed)

Related Links

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http://www.ll.dlpa.bru.nihr.ac.uk/

NIHR Leicester-Loughborough Diet, Lifestyle and Physical Activity Biomedical Research Unit

Other Identifiers

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MR/K025090/1

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

CRN18120

Identifier Type: REGISTRY

Identifier Source: secondary_id

UOLE0482

Identifier Type: OTHER

Identifier Source: secondary_id

0482

Identifier Type: -

Identifier Source: org_study_id

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