The Metabolic Road to Diastolic Heart Failure: Diastolic Heart Failure Study
NCT ID: NCT02446327
Last Updated: 2015-05-18
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
47 participants
INTERVENTIONAL
2012-01-31
2015-03-31
Brief Summary
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The aim was to recruit overall 750 patients in Europe (100 for France). Currently, 625 patients were enrolled in Europe and 47 in France.
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
DIAGNOSTIC
NONE
Study Groups
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Diastolic heart failure cohort
This is a prospective cohort of patients with diastolic heart failure. Blood sampling for biomarker assessment
Blood sampling for biomarker assessment
Interventions
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Blood sampling for biomarker assessment
Eligibility Criteria
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Inclusion Criteria
* Signs or symptoms of HF
* Able and willing to provide freely given written informed consent including analysis of genomics
Exclusion Criteria
* Recent trauma or surgery (\< 3 months)
* Hemodynamically significant valvular disease
* Serious cerebrovascular disease or stroke in the last 3 months
* Chronic dialysis
* Chronic liver disease
* Chronic infectious (bacterial or viral) disease
* Any malignant concomitant diseases or a malignant disease in the last 5 years
* Systemic inflammatory diseases, such as autoimmune diseases, connective tissue diseases or collagenoses
* Pregnant women
18 Years
ALL
No
Sponsors
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Central Hospital, Nancy, France
OTHER
Responsible Party
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References
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Lagrange J, Jahangiri M PhD, Baudry G, Mercier N, Monzo L, Lamiral Z, Duarte K, Ter Maaten JM, Zannad F, Voors AA, Girerd N. Association Between Endothelial Alterations, Cardiac Function, and Outcomes From Health to Heart Failure: Insight From the STANISLAS, MEDIA-DHF, and BIOSTAT-CHF Cohorts. J Am Heart Assoc. 2025 Jun 3;14(11):e040179. doi: 10.1161/JAHA.124.040179. Epub 2025 May 29.
Stienen S, Ferreira JP, Kobayashi M, Preud'homme G, Dobre D, Machu JL, Duarte K, Bresso E, Devignes MD, Andres NL, Girerd N, Aakhus S, Ambrosio G, Rocca HB, Fontes-Carvalho R, Fraser AG, van Heerebeek L, de Keulenaer G, Marino P, McDonald K, Mebazaa A, Papp Z, Raddino R, Tschope C, Paulus WJ, Zannad F, Rossignol P. Sex differences in circulating proteins in heart failure with preserved ejection fraction. Biol Sex Differ. 2020 Aug 24;11(1):47. doi: 10.1186/s13293-020-00322-7.
Other Identifiers
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2012-A00097-36
Identifier Type: -
Identifier Source: org_study_id
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