Brain Activity During Birth for Prediction of Newborns at Risk for Brain Injury

NCT ID: NCT02445417

Last Updated: 2018-09-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-06-25

Brief Summary

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The purpose of this study is early identification of asphyxiated newborns through eeg starting in the delivery room.

Detailed Description

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There is a need for a reliable detector of birth asphyxia so that newborns with birth asphyxia can have timely and accurate diagnosis to receive therapeutic hypothermia within 6 hrs of life, which has been shown to significantly reduce deaths and improve long term developmental outcomes.

This study is designed to record EEG during birth transition through the first 10 minutes of life.

Conditions

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Encephalopathy Asphyxia Newborns

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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EES

Epidermal Electronic System

No interventions assigned to this group

Hydrogel Electrode

Hydrogel based EEG electrode

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Signed Informed consent

Exclusion Criteria

* Known congenital anomalies
Minimum Eligible Age

36 Weeks

Maximum Eligible Age

44 Weeks

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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The Hartwell Foundation

OTHER

Sponsor Role collaborator

Sharp HealthCare

OTHER

Sponsor Role lead

Responsible Party

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M J Harbert

Director of Neonatal Neurology

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Mary J Harbert, MD

Role: PRINCIPAL_INVESTIGATOR

Sharp Mary Birch Hospital for Women & Newborns

Locations

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Sharp Mary Birch Hospital for Women and Newborns

San Diego, California, United States

Site Status

Countries

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United States

References

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Raghuveer TS, Cox AJ. Neonatal resuscitation: an update. Am Fam Physician. 2011 Apr 15;83(8):911-8.

Reference Type BACKGROUND
PMID: 21524031 (View on PubMed)

Perez A, Ritter S, Brotschi B, Werner H, Caflisch J, Martin E, Latal B. Long-term neurodevelopmental outcome with hypoxic-ischemic encephalopathy. J Pediatr. 2013 Aug;163(2):454-9. doi: 10.1016/j.jpeds.2013.02.003. Epub 2013 Mar 14.

Reference Type BACKGROUND
PMID: 23498155 (View on PubMed)

Massaro AN, Tsuchida T, Kadom N, El-Dib M, Glass P, Baumgart S, Chang T. aEEG evolution during therapeutic hypothermia and prediction of NICU outcome in encephalopathic neonates. Neonatology. 2012;102(3):197-202. doi: 10.1159/000339570. Epub 2012 Jul 12.

Reference Type BACKGROUND
PMID: 22796967 (View on PubMed)

Jacobs SE, Berg M, Hunt R, Tarnow-Mordi WO, Inder TE, Davis PG. Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane Database Syst Rev. 2013 Jan 31;2013(1):CD003311. doi: 10.1002/14651858.CD003311.pub3.

Reference Type BACKGROUND
PMID: 23440789 (View on PubMed)

Shalak LF, Laptook AR, Velaphi SC, Perlman JM. Amplitude-integrated electroencephalography coupled with an early neurologic examination enhances prediction of term infants at risk for persistent encephalopathy. Pediatrics. 2003 Feb;111(2):351-7. doi: 10.1542/peds.111.2.351.

Reference Type BACKGROUND
PMID: 12563063 (View on PubMed)

Kim DH, Lu N, Ma R, Kim YS, Kim RH, Wang S, Wu J, Won SM, Tao H, Islam A, Yu KJ, Kim TI, Chowdhury R, Ying M, Xu L, Li M, Chung HJ, Keum H, McCormick M, Liu P, Zhang YW, Omenetto FG, Huang Y, Coleman T, Rogers JA. Epidermal electronics. Science. 2011 Aug 12;333(6044):838-43. doi: 10.1126/science.1206157.

Reference Type BACKGROUND
PMID: 21836009 (View on PubMed)

Pichler G, Avian A, Binder C, Zotter H, Schmolzer GM, Morris N, Muller W, Urlesberger B. aEEG and NIRS during transition and resuscitation after birth: promising additional tools; an observational study. Resuscitation. 2013 Jul;84(7):974-8. doi: 10.1016/j.resuscitation.2012.12.025. Epub 2013 Jan 8.

Reference Type BACKGROUND
PMID: 23313424 (View on PubMed)

Other Identifiers

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Transition

Identifier Type: -

Identifier Source: org_study_id

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